| Id: | acc2414 |
| Group: | 2sens |
| Protein: | MRE11 |
| Gene Symbol: | MRE11 |
| Protein Id: | P49959 |
| Protein Name: | MRE11_HUMAN |
| PTM: | ubiquitination |
| Site: | Lys339 |
| Site Sequence: | QAIQSFCLEKIEEMLENAERE |
| Disease Category: | Cancer |
| Disease: | Breast Cancer |
| Disease Subtype: | TNBC |
| Disease Cellline: | HCC1806 |
| Disease Info: | |
| Drug: | radiotherapy |
| Drug Info: | - |
| Effect: | improve |
| Effect Info: | "DHA inhibits the expression of RNF126, and RNF126-mediated ubiquitination of MRE11 enhances the sensitivity of TNBC to radiotherapy." |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 36563124 |
| Sentence Index: | 36563124_8-9 |
| Sentence: | "Furthermore, it is found that RNF126 expression is induced by IR activating the HER2-AKT-NF-kappaB pathway and targeting RNF126 expression with dihydroartemisinin significantly improves the sensitivity of TNBC tumors in the brain to IR treatment in vivo. Together, these results reveal that RNF126-mediated MRE11 ubiquitination is a critical regulator of the DDR, which provides a promising target for improving the sensitivity of TNBC to radiotherapy." |
Sequence & Structure:
MSTADALDDENTFKILVATDIHLGFMEKDAVRGNDTFVTLDEILRLAQENEVDFILLGGDLFHENKPSRKTLHTCLELLRKYCMGDRPVQFEILSDQSVNFGFSKFPWVNYQDGNLNISIPVFSIHGNHDDPTGADALCALDILSCAGFVNHFGRSMSVEKIDISPVLLQKGSTKIALYGLGSIPDERLYRMFVNKKVTMLRPKEDENSWFNLFVIHQNRSKHGSTNFIPEQFLDDFIDLVIWGHEHECKIAPTKNEQQLFYISQPGSSVVTSLSPGEAVKKHVGLLRIKGRKMNMHKIPLHTVRQFFMEDIVLANHPDIFNPDNPKVTQAIQSFCLEKIEEMLENAERERLGNSHQPEKPLVRLRVDYSGGFEPFSVLRFSQKFVDRVANPKDIIHFFRHREQKEKTGEEINFGKLITKPSEGTTLRVEDLVKQYFQTAEKNVQLSLLTERGMGEAVQEFVDKEEKDAIEELVKYQLEKTQRFLKERHIDALEDKIDEEVRRFRETRQKNTNEEDDEVREAMTRARALRSQSEESASAFSADDLMSIDLAEQMANDSDDSISAATNKGRGRGRGRRGGRGQNSASRGGSQRGRADTGLETSTRSRNSKTAVSASRNMSIIDAFKSTRQQPSRNVTTKNYSEVIEVDESDVEEDIFPTTSKTDQRWSSTSSSKIMSQSQVSKGVDFESSEDDDDDPFMNTSSLRRNRR
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| K | 339 | U | Triple-negative breast cancer | Ubiquitination | 36563124 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
