| Id: | acc2504 |
| Group: | 2sens |
| Protein: | UVRAG |
| Gene Symbol: | UVRAG |
| Protein Id: | Q9P2Y5 |
| Protein Name: | UVRAG_HUMAN |
| PTM: | ubiquitination |
| Site: | Lys517 |
| Site Sequence: | SSENERLQYKTPPPSYNSALA |
| Disease Category: | Cancer |
| Disease: | Hepatocellular Carcinoma |
| Disease Subtype: | |
| Disease Cellline: | MHCC97H |
| Disease Info: | |
| Drug: | D4476 |
| Drug Info: | "D4476 is a potent, selective, and cell-permeable casein kinase 1 (CK1) inhibitor with an IC50 value of 0.3 μM in vitro." |
| Effect: | modulate |
| Effect Info: | "Blocking Ser522 phosphorylation by the CSNK1A1 inhibitor D4476 can enhance the lysosomal degradation of the epidermal growth factor receptor, thereby significantly inhibiting the growth of hepatocellular carcinoma (HCC)." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 30686098 |
| Sentence Index: | 30686098_7-8 |
| Sentence: | "Interestingly, ZRANB1 is phosphorylated at Thr35, and Ser209 residues by CSNK1A1, and this phosphorylation activates its deubiquitinating activity. Importantly, we provide in vitro and in vivo evidence that UVRAG ubiquitination at lysine residues 517 and 559 or prevention of Ser522 phosphorylation by D4476, a CSNK1A1 inhibitor, enhances the lysosomal degradation of EGFR, which significantly inhibits hepatocellular carcinoma (HCC) growth." |
Sequence & Structure:
MSASASVGGPVPQPPPGPAAALPPGSAARALHVELPSQQRRLRHLRNIAARNIVNRNGHQLLDTYFTLHLCSTEKIYKEFYRSEVIKNSLNPTWRSLDFGIMPDRLDTSVSCFVVKIWGGKENIYQLLIEWKVCLDGLKYLGQQIHARNQNEIIFGLNDGYYGAPFEHKGYSNAQKTILLQVDQNCVRNSYDVFSLLRLHRAQCAIKQTQVTVQKIGKEIEEKLRLTSTSNELKKKSECLQLKILVLQNELERQKKALGREVALLHKQQIALQDKGSAFSAEHLKLQLQKESLNELRKECTAKRELFLKTNAQLTIRCRQLLSELSYIYPIDLNEHKDYFVCGVKLPNSEDFQAKDDGSIAVALGYTAHLVSMISFFLQVPLRYPIIHKGSRSTIKDNINDKLTEKEREFPLYPKGGEKLQFDYGVYLLNKNIAQLRYQHGLGTPDLRQTLPNLKNFMEHGLMVRCDRHHTSSAIPVPKRQSSIFGGADVGFSGGIPSPDKGHRKRASSENERLQYKTPPPSYNSALAQPVTTVPSMGETERKITSLSSSLDTSLDFSKENKKKGEDLVGSLNGGHANVHPSQEQGEALSGHRATVNGTLLPSEQAGSASVQLPGEFHPVSEAELCCTVEQAEEIIGLEATGFASGDQLEAFNCIPVDSAVAVECDEQVLGEFEEFSRRIYALNENVSSFRRPRRSSDK
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
