| Id: | acc2514 |
| Group: | 2sens |
| Protein: | PD-L1 |
| Gene Symbol: | Cd274 |
| Protein Id: | Q9EP73 |
| Protein Name: | PD1L1_MOUSE |
| PTM: | ubiquitination |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cancer |
| Disease: | Lung Cancer |
| Disease Subtype: | |
| Disease Cellline: | LLC |
| Disease Info: | |
| Drug: | DHA |
| Drug Info: | - |
| Effect: | modulate |
| Effect Info: | DHA can promote the ubiquitin - proteasome degradation of PD - L1 and reverse the PD - L1 - mediated immunosuppression. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 36309154 |
| Sentence Index: | 36309154_4-5 |
| Sentence: | "In this study, we demonstrated for the first time that omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid (DHA) reduced the expression of PD-L1 in cancer cells both in vitro and in vivo. Promotion of PD-L1 ubiquitin-proteasome degradation by DHA resulted in a decrease of PD-L1 expression, leading to reduction of PD-L1 and PD-1 interaction, and reversing PD-L1-mediated immune suppression, which in turn contributed to the inhibitory effect on tumor growth." |
Sequence & Structure:
MRIFAGIIFTACCHLLRAFTITAPKDLYVVEYGSNVTMECRFPVERELDLLALVVYWEKEDEQVIQFVAGEEDLKPQHSNFRGRASLPKDQLLKGNAALQITDVKLQDAGVYCCIISYGGADYKRITLKVNAPYRKINQRISVDPATSEHELICQAEGYPEAEVIWTNSDHQPVSGKRSVTTSRTEGMLLNVTSSLRVNATANDVFYCTFWRSQPGQNHTAELIIPELPATHPPQNRTHWVLLGSILLFLIVVSTVLLFLRKQVRMLDVEKCGVEDTSSKNRNDTQFEET
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| Y | 112 | U | Liver cancer | Phosphorylation | 31305264 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
