| Id: | acc2537 |
| Group: | 2sens |
| Protein: | MKP-1 |
| Gene Symbol: | DUSP14 |
| Protein Id: | O95147 |
| Protein Name: | DUS14_HUMAN |
| PTM: | S-nitrosylation |
| Site: | Cys258 |
| Site Sequence: | ----------------------------------------------------------------------- |
| Disease Category: | Cancer |
| Disease: | Head and Neck Cancer |
| Disease Subtype: | HNSCC |
| Disease Cellline: | MDA-1483 |
| Disease Info: | |
| Drug: | radiotherapy |
| Drug Info: | - |
| Effect: | decrease |
| Effect Info: | S-nitrosylation of proteins reduces the sensitivity to radiotherapy. |
| Note: | Non-conventional drugs |
| Score: | 4.5 |
| Pubmed(PMID): | 22014408 |
| Sentence Index: | 22014408_4-5 |
| Sentence: | "Here we show that S-nitrosylation of MKP-1 on Cysteine 258 enhances MKP-1 protein stability, phosphatase activity, and MKP-1-mediated anti-apoptotic effect on HNC radiotherapy. Co-culturing MKP-1 transfected HNC cell lines with activated macrophages for mimicking the microenvironment of the irradiated cancer cells further confirms that S-nitrosylation-mediated increase of MKP-1 activity correlates with decrease of HNC radiosensitivity." |
Sequence & Structure:
MSSRGHSTLPRTLMAPRMISEGDIGGIAQITSSLFLGRGSVASNRHLLQARGITCIVNATIEIPNFNWPQFEYVKVPLADMPHAPIGLYFDTVADKIHSVSRKHGATLVHCAAGVSRSATLCIAYLMKFHNVCLLEAYNWVKARRPVIRPNVGFWRQLIDYERQLFGKSTVKMVQTPYGIVPDVYEKESRHLMPYWGI
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
