Id: acc2556
Group: 2sens
Protein: Trx1
Gene Symbol: TXN
Protein Id: P10599
Protein Name: THIO_HUMAN
PTM: oxidation
Site: unclear
Site Sequence:
Disease Category: Cancer
Disease: Prostate Cancer
Disease Subtype:
Disease Cellline: PC3
Disease Info:
Drug: 2DG + DHEA
Drug Info: "2DG (2-Deoxy-D-glucose) is a glucose analog that inhibits glycolysis by competitively blocking glucose metabolism, often used in cancer research to study metabolic pathways and potential therapeutic targets. DHEA (Dehydroepiandrosterone) is a steroid hormone precursor with roles in immune modulation, metabolism, and anti-aging research, often studied for its potential effects on energy balance and cellular function"
Effect: enhance
Effect Info: Protein oxidation promotes the efficacy of drugs in killing cancer cells.
Note:
Score: 5.0
Pubmed(PMID): 25560241
Sentence Index:
Sentence:

Sequence & Structure:

MVKQIESKTAFQEALDAAGDKLVVVDFSATWCGPCKMIKPFFHSLSEKYSNVIFLEVDVDDCQDVASECEVKCMPTFQFFKKGQKVGEFSGANKEKLEATINELV

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
TXN PX-12 Thioredoxin inhibitor 2 Terminated pancreatic neoplasm ClinicalTrials
TXN PX-12 Thioredoxin inhibitor 1 Completed cancer ClinicalTrials
TXN PX-12 Thioredoxin inhibitor 1 Completed metastatic malignant neoplasm ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: