Id: | acc2563 |
Group: | 2sens |
Protein: | PKM2 |
Gene Symbol: | PKM |
Protein Id: | P14618 |
Protein Name: | KPYM_HUMAN |
PTM: | glycosylation |
Site: | Arg399 |
Site Sequence: | YHLQLFEELRRLAPITSDPTE |
Disease Category: | Cancer |
Disease: | Cancer |
Disease Subtype: | |
Disease Cellline: | |
Disease Info: | |
Drug: | MG |
Drug Info: | Atogepant (Qulipta) is a calcitonin gene-related peptide (CGRP) receptor antagonist indicated for the preventive treatment of episodic migraine in adults. |
Effect: | inhibit |
Effect Info: | "Glycosylation of PKM2 protein and others inhibit GAPDH in tumor cells, without clearly stating the activity." |
Note: | |
Score: | 5.0 |
Pubmed(PMID): | 26911935 |
Sentence Index: | 26911935_17-18 |
Sentence: | Association of GAPDH with PKM2 and GPI could be a signature for cancer cells. Glycation at R399 of PKM2 and changes in the secondary structure of GAPDH complex could be one of the mechanisms by which GAPDH activity is inhibited in tumor cells by MG. |
Sequence & Structure:
MSKPHSEAGTAFIQTQQLHAAMADTFLEHMCRLDIDSPPITARNTGIICTIGPASRSVETLKEMIKSGMNVARLNFSHGTHEYHAETIKNVRTATESFASDPILYRPVAVALDTKGPEIRTGLIKGSGTAEVELKKGATLKITLDNAYMEKCDENILWLDYKNICKVVEVGSKIYVDDGLISLQVKQKGADFLVTEVENGGSLGSKKGVNLPGAAVDLPAVSEKDIQDLKFGVEQDVDMVFASFIRKASDVHEVRKVLGEKGKNIKIISKIENHEGVRRFDEILEASDGIMVARGDLGIEIPAEKVFLAQKMMIGRCNRAGKPVICATQMLESMIKKPRPTRAEGSDVANAVLDGADCIMLSGETAKGDYPLEAVRMQHLIAREAEAAIYHLQLFEELRRLAPITSDPTEATAVGAVEASFKCCSGAIIVLTKSGRSAHQVARYRPRAPIIAVTRNPQTARQAHLYRGIFPVLCKDPVQEAWAEDVDLRVNFAMNVGKARGFFKKGDVVIVLTGWRPGSGFTNTMRVVPVP
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
- | - | D | Psoriasis | Acetylation | 32679047 |
K | 433 | D | Hepatocellular carcinoma | Acetylation | 34016961 |
Y | 105 | P | Lung adenocarcinoma | Phosphorylation | 36428781 |
Y | 105 | P | Pancreatic cancer | Phosphorylation | 36244646 |
S | 37 | P | Glioblastoma | Phosphorylation | 27485204 |
S | 37 | P | Breast cancer | Phosphorylation | 34966685 |
S | 100 | U | Triple-negative breast cancer | Phosphorylation | 34244606 |
S | 37 | U | Triple-negative breast cancer | Phosphorylation | 34185676 |
S | 37 | U | Non-small cell lung cancer | Phosphorylation | 35790734 |
S | 37 | U | Colorectal cancer | Phosphorylation | 35973989 |
S | 222 | U | Glioblastoma | Phosphorylation | 35048565 |
- | - | U | Diffuse large B-cell lymphoma | Phosphorylation | 34168996 |
Y | 105 | U | Head and neck squamous cell carcinoma | Phosphorylation | 35054968 |
- | - | U | Ovarian cancer | Ubiquitination | 34382324 |
Y | 105 | U | Cervical cancer | Phosphorylation | 33800513 |
- | - | U | Gastric cancer | Ubiquitination | 37624791 |
- | - | U | Hepatocellular carcinoma | Ubiquitination | 37594129 |
Y | 105 | U | Prostate cancer | Phosphorylation | 36400183 |
Y | 105 | U | Breast cancer | Phosphorylation | 29440169 |
- | - | U | Liver fibrosis | Phosphorylation | 35140065 |
T | 45 | U | Lung cancer | Phosphorylation | 36198360 |
T | 45 | U | Cancer | Phosphorylation | 36417819 |
T | 328 | U | Glioblastoma multiforme | Phosphorylation | 30297868 |
S | 37 | U | Lymphangiomyomatosis | Phosphorylation | 32078667 |
S | 37 | U | Glioblastoma multiforme | Phosphorylation | 23178880 |
K | 433 | U | Breast cancer | Acetylation | 24120661 |
K | 305 | U | Prostate cancer | Acetylation | 21700219 |
K | 433 | U | Leukemia | Acetylation | 29641204 |
K | 433 | U | Hepatocellular carcinoma | Acetylation | 34016961 ;  26787900 |
K | 305 | U | Breast cancer | Acetylation | 27197174 |
K | 62 | U | Hepatocellular carcinoma | Acetylation | 33279948 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.