Id: acc2580
Group: 1sens
Protein: IkappaBalpha
Gene Symbol: NFKBIA
Protein Id: P25963
Protein Name: IKBA_HUMAN
PTM: phosphorylation
Site: Ser32
Site Sequence: ERLLDDRHDSGLDSMKDEEYE
Disease Category: Cancer
Disease: Gastric Cancer
Disease Subtype:
Disease Cellline: BGC-823
Disease Info:
Drug: N-acetylcysteine(NAC)
Drug Info: "N-Acetylcysteine (NAC) is a mucolytic agent and antioxidant that works by breaking down disulfide bonds in mucus proteins to reduce viscosity, and it is also used as an antidote for acetaminophen overdose by replenishing glutathione stores to prevent hepatotoxicity."
Effect: modulate
Effect Info: The drug inhibits the proliferation and migration of gastric cancer cells and simultaneously suppresses protein phosphorylation.
Note:
Score: 4.0
Pubmed(PMID): 32021099
Sentence Index:
Sentence:

Sequence & Structure:

MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
NFKBIA-Ser32
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 32 U Head and neck squamous cell carcinoma Phosphorylation 21281788
T 32 U Head and neck squamous cell carcinoma Phosphorylation 21281788

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: