| Id: | acc2589 |
| Group: | 2sens |
| Protein: | RNF4 |
| Gene Symbol: | RNF4 |
| Protein Id: | P78317 |
| Protein Name: | RNF4_HUMAN |
| PTM: | methylation |
| Site: | Arg164 |
| Site Sequence: | GHVFCSQCLRDSLKNANTCPT |
| Disease Category: | Cancer |
| Disease: | Leukemia |
| Disease Subtype: | Acute promyelocytic leukemia |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | As2O3 |
| Drug Info: | Arsenic trioxide (As?O?) is a chemotherapeutic agent primarily used in the treatment of acute promyelocytic leukemia (APL) by inducing differentiation and apoptosis of leukemic cells. |
| Effect: | resist |
| Effect Info: | Protein methylation makes tumors resistant to drugs. |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 35622143 |
| Sentence Index: | 35622143_0-1 |
| Sentence: | "PRMT5-mediated RNF4 methylation promotes therapeutic resistance of APL cells to As2O3 by stabilizing oncoprotein PML-RARalpha. Acute promyelocytic leukemia (APL) is a hematological malignancy driven by the oncoprotein PML-RARalpha, which can be treated with arsenic trioxide (As2O3) or/and all-trans retinoic acid." |
Sequence & Structure:
MSTRKRRGGAINSRQAQKRTREATSTPEISLEAEPIELVETAGDEIVDLTCESLEPVVVDLTHNDSVVIVDERRRPRRNARRLPQDHADSCVVSSDDEELSRDRDVYVTTHTPRNARDEGATGLRPSGTVSCPICMDGYSEIVQNGRLIVSTECGHVFCSQCLRDSLKNANTCPTCRKKINHKRYHPIYI
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
