Id: acc3003
Group: 1sens_supp
Protein: BAD
Gene Symbol: BAD
Protein Id: Q92934
Protein Name: BAD_HUMAN
PTM: phosphorylation
Site: unclear
Site Sequence:
Disease Category: Cancer
Disease: Colorectal Cancer
Disease Subtype:
Disease Cellline: COLO205
Disease Info:
Drug: gossypol acetic acid
Drug Info: "Gossypol acetic acid is a chemical compound that has been studied for its potential biological activities, such as anti - tumor effects. "
Effect: modulate
Effect Info: GOS or gossypol acetic acid (GAA) significantly reduced the growth of colorectal cancer induced by subcutaneous injection of COLO205 cells in nude mice. A decrease in phosphorylated Bad protein was found in GOS-treated cells.
Note:
Score: 4.0
Pubmed(PMID): 17597109
Sentence Index:
Sentence:

Sequence & Structure:

MFQIPEFEPSEQEDSSSAERGLGPSPAGDGPSGSGKHHRQAPGLLWDASHQQEQPTSSSHHGGAGAVEIRSRHSSYPAGTEDDEGMGEEPSPFRGRSRSAPPNLWAAQRYGRELRRMSDEFVDSFKKGLPRPKSAGTATQMRQSSSWTRVFQSWWDRNLGRGSSAPSQ

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

BAD-Ser118
Cancer Intensity
BRCA 1.02
COAD 0.094
HGSC -2.688
ccRCC 0.665
GBM -0.315
HNSC 0.337
LUAD -0.509
LUSC 0.254
non_ccRCC 0.67
PDAC 0.544
UCEC -0.072
BAD-Ser134
Cancer Intensity
BRCA 0.496
COAD 0.025
HGSC -2.571
ccRCC 0.505
GBM -0.168
HNSC -0.14
LUAD 0.142
LUSC 0.308
non_ccRCC 1.623
PDAC 0.07
UCEC -0.291
BAD-Ser146
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC 0.707
PDAC -0.707
UCEC
BAD-Ser25
Cancer Intensity
BRCA 1.201
COAD 0.333
HGSC -2.06
ccRCC 0.071
GBM 0.221
HNSC 0.141
LUAD 0.314
LUSC -0.147
non_ccRCC 1.088
PDAC -1.618
UCEC 0.456
BAD-Ser32
Cancer Intensity
BRCA
COAD 0.634
HGSC
ccRCC -0.649
GBM -0.387
HNSC -1.466
LUAD 0.675
LUSC
non_ccRCC
PDAC
UCEC 1.193
BAD-Ser34
Cancer Intensity
BRCA
COAD 0.402
HGSC -2.657
ccRCC 0.246
GBM 0.244
HNSC
LUAD 0.294
LUSC 0.335
non_ccRCC 0.503
PDAC 0.255
UCEC 0.378
BAD-Ser75
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
BAD-Ser91
Cancer Intensity
BRCA
COAD
HGSC 0.707
ccRCC
GBM -0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
BAD-Ser99
Cancer Intensity
BRCA 0.402
COAD -1.167
HGSC 1.633
ccRCC -1.772
GBM -0.506
HNSC -0.659
LUAD -0.029
LUSC 0.613
non_ccRCC 0.977
PDAC -0.255
UCEC 0.764
BAD-Thr80
Cancer Intensity
BRCA
COAD 0.707
HGSC -0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
BAD-Tyr76
Cancer Intensity
BRCA
COAD 0.707
HGSC -0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
- - P Mesothelioma Phosphorylation 14729617
- - U Parkinson's disease Phosphorylation 23519076
- - U Ovarian cancer/carcinoma Phosphorylation 10999766

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: