| Id: | acc3018 |
| Group: | 2sens |
| Protein: | SNAP-25 |
| Gene Symbol: | Snap25 |
| Protein Id: | P60881 |
| Protein Name: | SNP25_RAT |
| PTM: | phosphorylation |
| Site: | Ser187 |
| Site Sequence: | IDRIMEKADSNKTRIDEANQR |
| Disease Category: | Nervous system diseases |
| Disease: | Synaptic Plasticity |
| Disease Subtype: | |
| Disease Cellline: | PC12 cells |
| Disease Info: | |
| Drug: | PMA |
| Drug Info: | PMA is a type of drug that can have harmful effects on the body and is often associated with serious health risks. |
| Effect: | no effect |
| Effect Info: | "PMA enhances PKC-mediated phosphorylation of SNAP-25 at Ser???, promotes neurotransmitter release by regulating the interaction of SNARE complexes, and provides a new mechanism for understanding the molecular regulation of synaptic transmission and related neural functions (such as learning and memory)." |
| Note: | |
| Score: | 2.0 |
| Pubmed(PMID): | 8662851 |
| Sentence Index: | 8662851_6-7 |
| Sentence: | "A phosphorylation is likely to occur at Ser187, as this is the only Ser residue located between the cleavage sites of botulinum type A and E neurotoxins. SNAP-25 of PC12 cells was phosphorylated by purified protein kinase C in vitro, and the amount of syntaxin co-immunoprecipitated with SNAP-25 was decreased by phosphorylation." |
Sequence & Structure:
MAEDADMRNELEEMQRRADQLADESLESTRRMLQLVEESKDAGIRTLVMLDEQGEQLERIEEGMDQINKDMKEAEKNLTDLGKFCGLCVCPCNKLKSSDAYKKAWGNNQDGVVASQPARVVDEREQMAISGGFIRRVTNDARENEMDENLEQVSGIIGNLRHMALDMGNEIDTQNRQIDRIMEKADSNKTRIDEANQRATKMLGSG
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
