| Id: | acc3025 |
| Group: | 2sens |
| Protein: | GATA4 |
| Gene Symbol: | Gata4 |
| Protein Id: | Q08369 |
| Protein Name: | GATA4_MOUSE |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Apoptosis of Cardiac Muscle Cell |
| Disease Subtype: | Apoptosis Of Cardiac Muscle Cell |
| Disease Cellline: | HL-1 |
| Disease Info: | |
| Drug: | mercury |
| Drug Info: | Mercury is a heavy metal. It is not typically used as a conventional drug but can have toxic effects on the human body. |
| Effect: | modulate |
| Effect Info: | "In mercury-treated HL-1 cardiomyocytes, GATA-4 is activated and phosphorylated via the MEK/ERK signaling pathway, enhancing its DNA-binding activity and thus slowing down cell death." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 12788478 |
| Sentence Index: | 12788478_9-10 |
| Sentence: | "Consistent with a previous finding that GATA-4 phosphorylation induces cell survival, mercury decreases cell death induced by DNR. These results suggest that cardiac muscle cells respond to mercury stress by eliciting MEK/ERK signaling to form phosphorylated GATA-4 that is more resistant to cellular degradation and induce cell survival." |
Sequence & Structure:
MYQSLAMAANHGPPPGAYEAGGPGAFMHSAGAASSPVYVPTPRVPSSVLGLSYLQGGGSAAAAGTTSGGSSGAGPSGAGPGTQQGSPGWSQAGAEGAAYTPPPVSPRFSFPGTTGSLAAAAAAAAAREAAAYGSGGGAAGAGLAGREQYGRPGFAGSYSSPYPAYMADVGASWAAAAAASAGPFDSPVLHSLPGRANPGRHPNLDMFDDFSEGRECVNCGAMSTPLWRRDGTGHYLCNACGLYHKMNGINRPLIKPQRRLSASRRVGLSCANCQTTTTTLWRRNAEGEPVCNACGLYMKLHGVPRPLAMRKEGIQTRKRKPKNLNKSKTPAGPAGETLPPSSGASSGNSSNATSSSSSSEEMRPIKTEPGLSSHYGHSSSMSQTFSTVSGHGPSIHPVLSALKLSPQGYASPVTQTSQASSKQDSWNSLVLADSHGDIITA
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
