Id: acc3029
Group: 2sens
Protein: STAT5
Gene Symbol: STAT5
Protein Id: P42229
Protein Name: STA5A_HUMAN
PTM: phosphorylation
Site: Tyr694
Site Sequence: PVLAKAVDGYVKPQIKQVVPE
Disease Category: Cancer
Disease: Melanoma
Disease Subtype:
Disease Cellline: LU1205
Disease Info:
Drug: PD98059 + LY294002
Drug Info: PD98059 is a chemical compound used in biological research. | LY294002 is a commonly used inhibitor in scientific studies.
Effect: modulate
Effect Info: "After using the MEK–ERK inhibitor PD98059 and the PI3K inhibitor LY294002, the GAS–Luc activity of LU1205 cells was significantly increased, and the tyrosine phosphorylation of STAT3/5 and JAK2 was enhanced, indicating that the MAPK and PI3K signaling pathways inhibited the phosphorylation of JAK/STAT."
Note: drug comb
Score: 4.0
Pubmed(PMID): 12821943
Sentence Index:
Sentence:

Sequence & Structure:

MAGWIQAQQLQGDALRQMQVLYGQHFPIEVRHYLAQWIESQPWDAIDLDNPQDRAQATQLLEGLVQELQKKAEHQVGEDGFLLKIKLGHYATQLQKTYDRCPLELVRCIRHILYNEQRLVREANNCSSPAGILVDAMSQKHLQINQTFEELRLVTQDTENELKKLQQTQEYFIIQYQESLRIQAQFAQLAQLSPQERLSRETALQQKQVSLEAWLQREAQTLQQYRVELAEKHQKTLQLLRKQQTIILDDELIQWKRRQQLAGNGGPPEGSLDVLQSWCEKLAEIIWQNRQQIRRAEHLCQQLPIPGPVEEMLAEVNATITDIISALVTSTFIIEKQPPQVLKTQTKFAATVRLLVGGKLNVHMNPPQVKATIISEQQAKSLLKNENTRNECSGEILNNCCVMEYHQATGTLSAHFRNMSLKRIKRADRRGAESVTEEKFTVLFESQFSVGSNELVFQVKTLSLPVVVIVHGSQDHNATATVLWDNAFAEPGRVPFAVPDKVLWPQLCEALNMKFKAEVQSNRGLTKENLVFLAQKLFNNSSSHLEDYSGLSVSWSQFNRENLPGWNYTFWQWFDGVMEVLKKHHKPHWNDGAILGFVNKQQAHDLLINKPDGTFLLRFSDSEIGGITIAWKFDSPERNLWNLKPFTTRDFSIRSLADRLGDLSYLIYVFPDRPKDEVFSKYYTPVLAKAVDGYVKPQIKQVVPEFVNASADAGGSSATYMDQAPSPAVCPQAPYNMYPQNPDHVLDQDGEFDLDETMDVARHVEELLRRPMDSLDSRLSPPAGLFTSARGSLS

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

STAT5A-Ser128
Cancer Intensity
BRCA
COAD -0.707
HGSC 0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
STAT5A-Ser193
Cancer Intensity
BRCA 1.009
COAD 0.857
HGSC
ccRCC -1.072
GBM
HNSC -0.133
LUAD -0.416
LUSC 0.699
non_ccRCC -1.956
PDAC 0.705
UCEC 0.307
STAT5A-Ser777
Cancer Intensity
BRCA
COAD
HGSC
ccRCC -1.133
GBM
HNSC 0.761
LUAD 0.372
LUSC
non_ccRCC
PDAC
UCEC
STAT5A-Ser780
Cancer Intensity
BRCA 0.009
COAD 0.02
HGSC 1.43
ccRCC -0.433
GBM 2.195
HNSC -0.072
LUAD -0.075
LUSC -0.269
non_ccRCC -0.599
PDAC -0.913
UCEC -1.294
STAT5A-Tyr694
Cancer Intensity
BRCA -0.21
COAD 0.081
HGSC 2.396
ccRCC 0.242
GBM -0.214
HNSC 0.119
LUAD 0.595
LUSC 0.038
non_ccRCC -1.223
PDAC -0.376
UCEC -1.449
STAT5B-Ser128
Cancer Intensity
BRCA
COAD 0.523
HGSC -1.153
ccRCC 0.63
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
STAT5B-Ser193
Cancer Intensity
BRCA -0.438
COAD -0.511
HGSC 0.003
ccRCC -1.881
GBM 0.603
HNSC 1.089
LUAD -0.275
LUSC 1.849
non_ccRCC -0.664
PDAC 0.612
UCEC -0.387
STAT5B-Tyr699
Cancer Intensity
BRCA -0.21
COAD 0.081
HGSC 2.396
ccRCC 0.242
GBM -0.214
HNSC 0.119
LUAD 0.595
LUSC 0.038
non_ccRCC -1.223
PDAC -0.376
UCEC -1.449

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: