| Id: | acc3049 |
| Group: | 2sens |
| Protein: | NBS1 |
| Gene Symbol: | NBN |
| Protein Id: | O60934 |
| Protein Name: | NBN_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser343 |
| Site Sequence: | KTTTPGPSLSQGVSVDEKLMP |
| Disease Category: | Cancer |
| Disease: | Cancer |
| Disease Subtype: | |
| Disease Cellline: | OVCAR3? |
| Disease Info: | |
| Drug: | irofulven |
| Drug Info: | Irofulven is a drug with potential anti - cancer properties and is being studied in oncology research. |
| Effect: | modulate |
| Effect Info: | "After irofulven treatment, ATM-dependent induction of NBS1 phosphorylation is part of the DNA damage response." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 15269203 |
| Sentence Index: | 15269203_9-10 |
| Sentence: | "In addition, it was shown that NBS1, SMC1, and p53 were phosphorylated in an ATM-dependent manner, and p53 phosphorylation on serine 20 is dependent on CHK2 after irofulven treatment. In summary, we found that the anticancer agent, irofulven, activates the ATM-CHK2 DNA damage-signaling pathway, and CHK2 activation contributes to S phase cell cycle arrest induced by irofulven." |
Sequence & Structure:
MWKLLPAAGPAGGEPYRLLTGVEYVVGRKNCAILIENDQSISRNHAVLTANFSVTNLSQTDEIPVLTLKDNSKYGTFVNEEKMQNGFSRTLKSGDGITFGVFGSKFRIEYEPLVACSSCLDVSGKTALNQAILQLGGFTVNNWTEECTHLVMVSVKVTIKTICALICGRPIVKPEYFTEFLKAVESKKQPPQIESFYPPLDEPSIGSKNVDLSGRQERKQIFKGKTFIFLNAKQHKKLSSAVVFGGGEARLITEENEEEHNFFLAPGTCVVDTGITNSQTLIPDCQKKWIQSIMDMLQRQGLRPIPEAEIGLAVIFMTTKNYCDPQGHPSTGLKTTTPGPSLSQGVSVDEKLMPSAPVNTTTYVADTESEQADTWDLSERPKEIKVSKMEQKFRMLSQDAPTVKESCKTSSNNNSMVSNTLAKMRIPNYQLSPTKLPSINKSKDRASQQQQTNSIRNYFQPSTKKRERDEENQEMSSCKSARIETSCSLLEQTQPATPSLWKNKEQHLSENEPVDTNSDNNLFTDTDLKSIVKNSASKSHAAEKLRSNKKREMDDVAIEDEVLEQLFKDTKPELEIDVKVQKQEEDVNVRKRPRMDIETNDTFSDEAVPESSKISQENEIGKKRELKEDSLWSAKEISNNDKLQDDSEMLPKKLLLTEFRSLVIKNSTSRNPSGINDDYGQLKNFKKFKKVTYPGAGKLPHIIGGSDLIAHHARKNTELEEWLRQEMEVQNQHAKEESLADDLFRYNPYLKRRR
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTAC| NBN-Ser343 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.77 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.674 |
| LUAD | -0.047 |
| LUSC | -1.397 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
