PMADS

Id:	acc3050
Group:	2sens
Protein:	p53
Gene Symbol:	TP53
Protein Id:	P04637
Protein Name:	P53_HUMAN
PTM:	phosphorylation
Site:	Ser15
Site Sequence:	SDPSVEPPLSQETFSDLWKLL
Disease Category:	Cancer
Disease:	Cancer
Disease Subtype:
Disease Cellline:	A2780?
Disease Info:
Drug:	irofulven
Drug Info:	Irofulven is a drug with potential anti - cancer properties and is being studied in oncology research.
Effect:	modulate
Effect Info:	"After Irofulven treatment, p53 phosphorylation is induced via the ATM - CHK2 pathway, which may promote apoptosis or cell - cycle arrest."
Note:
Score:	4.0
Pubmed(PMID):	15269203
Sentence Index:	15269203_9-10
Sentence:	"In addition, it was shown that NBS1, SMC1, and p53 were phosphorylated in an ATM-dependent manner, and p53 phosphorylation on serine 20 is dependent on CHK2 after irofulven treatment. In summary, we found that the anticancer agent, irofulven, activates the ATM-CHK2 DNA damage-signaling pathway, and CHK2 activation contributes to S phase cell cycle arrest induced by irofulven."

Sequence & Structure:

MEEPQSDPSVEPPLSQETFSDLWKLLPENNVLSPLPSQAMDDLMLSPDDIEQWFTEDPGPDEAPRMPEAAPPVAPAPAAPTPAAPAPAPSWPLSSSVPSQKTYQGSYGFRLGFLHSGTAKSVTCTYSPALNKMFCQLAKTCPVQLWVDSTPPPGTRVRAMAIYKQSQHMTEVVRRCPHHERCSDSDGLAPPQHLIRVEGNLRVEYLDDRNTFRHSVVVPYEPPEVGSDCTTIHYNYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRNSFEVRVCACPGRDRRTEEENLRKKGEPHHELPPGSTKRALPNNTSSSPQPKKKPLDGEYFTLQIRGRERFEMFRELNEALELKDAQAGKEPGGSRAHSSHLKSKKGQSTSRHKKLMFKTEGPDSD

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target	Drug name	MOA	Phase	Status	Disease	Source
TP53	EPRENETAPOPT	Cellular tumor antigen p53 stabiliser	3	Completed	myelodysplastic syndrome	ClinicalTrials
TP53	IDASANUTLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	3	Terminated	acute myeloid leukemia	ClinicalTrials
TP53	CENERSEN SODIUM	p53 mRNA antisense inhibitor	2	Terminated	chronic lymphocytic leukemia	ClinicalTrials
TP53	CENERSEN	p53 mRNA antisense inhibitor	2	Completed	acute myeloid leukemia	ClinicalTrials
TP53	CENERSEN	p53 mRNA antisense inhibitor	2	Withdrawn	acute myeloid leukemia	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	essential thrombocythemia	ClinicalTrials
TP53	SIREMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	neoplasm	ClinicalTrials
TP53	IDASANUTLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	neoplasm	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Terminated	small cell lung carcinoma	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Active, not recruiting	polycythemia vera	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	polycythemia vera	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	primary myelofibrosis	ClinicalTrials
TP53	IDASANUTLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Terminated	polycythemia vera	ClinicalTrials
TP53	CONTUSUGENE LADENOVEC	Cellular tumor antigen p53 exogenous gene	2	Unknown status	non-small cell lung carcinoma	ClinicalTrials
TP53	APG115	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	lymphoid leukemia	ClinicalTrials
TP53	CONTUSUGENE LADENOVEC	Cellular tumor antigen p53 exogenous gene	2	Terminated	head and neck malignant neoplasia	ClinicalTrials
TP53	CONTUSUGENE LADENOVEC	Cellular tumor antigen p53 exogenous gene	2	Unknown status	head and neck malignant neoplasia	ClinicalTrials ClinicalTrials
TP53	EPRENETAPOPT	Cellular tumor antigen p53 stabiliser	2	Withdrawn	Mantle cell lymphoma	ClinicalTrials
TP53	TEPRASIRAN	p53 mRNA RNAi inhibitor	2	Completed	Acute kidney injury	ClinicalTrials
TP53	EPRENETAPOPT	Cellular tumor antigen p53 stabiliser	2	Completed	ovarian cancer	ClinicalTrials
TP53	CONTUSUGENE LADENOVEC	Cellular tumor antigen p53 exogenous gene	2	Completed	breast cancer	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	2	Recruiting	endometrial cancer	ClinicalTrials
TP53	CENERSEN	p53 mRNA antisense inhibitor	1	Terminated	myelodysplastic syndrome	ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	1	Active, not recruiting	acute myeloid leukemia	ClinicalTrials ClinicalTrials
TP53	NAVTEMADLIN	Tumour suppressor p53/oncoprotein Mdm2 inhibitor	1	Completed	acute myeloid leukemia	ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets

Small molecule

Antibody

PROTAC

Other modalities

Approved Drug

Advanced Clinical

Phase 1 Clinical

Structure with Ligand

High-Quality Ligand

High-Quality Pocket

Med-Quality Pocket

Druggable Family

Approved Drug

Advanced Clinical

Phase 1 Clinical

UniProt loc high conf

GO CC high conf

UniProt loc med conf

UniProt SigP or TMHMM

GO CC med conf

Human Protein Atlas loc

Approved Drug

Advanced Clinical

Phase 1 Clinical

Literature

UniProt Ubiquitination

Database Ubiquitination

Half-life Data

Small Molecule Binder

Approved Drug

Advanced Clinical

Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

TP53-Ser314
Cancer	Intensity
BRCA
COAD	0.707
HGSC
ccRCC
GBM
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53-Ser315
Cancer	Intensity
BRCA
COAD	-1.105
HGSC	0.842
ccRCC	0.263
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53-Thr150
Cancer	Intensity
BRCA
COAD
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser101
Cancer	Intensity
BRCA
COAD	0.422
HGSC	-1.142
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.72

TP53BP1-Ser1024
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.707
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1030
Cancer	Intensity
BRCA
COAD	-1.646
HGSC
ccRCC	0.325
GBM	1.443
HNSC	-0.173
LUAD	0.213
LUSC
non_ccRCC
PDAC
UCEC	-0.162

TP53BP1-Ser1033
Cancer	Intensity
BRCA	1.211
COAD	-0.937
HGSC	2.312
ccRCC	-0.583
GBM	-0.187
HNSC	-0.362
LUAD	-0.923
LUSC	-0.762
non_ccRCC	0.539
PDAC	-0.285
UCEC	-0.023

TP53BP1-Ser1039
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC	0.707
non_ccRCC
PDAC
UCEC	-0.707

TP53BP1-Ser1072
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	1.378
ccRCC	0.381
GBM	0.572
HNSC	-1.199
LUAD	-1.107
LUSC
non_ccRCC
PDAC
UCEC	0.682

TP53BP1-Ser1073
Cancer	Intensity
BRCA	0.669
COAD	-1.359
HGSC	1.711
ccRCC	0.013
GBM	-1.1
HNSC	-0.352
LUAD	-0.325
LUSC	-0.93
non_ccRCC	1.416
PDAC	0.594
UCEC	-0.338

TP53BP1-Ser108
Cancer	Intensity
BRCA
COAD
HGSC	-1.494
ccRCC	0.385
GBM
HNSC	0.592
LUAD	0.518
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1091
Cancer	Intensity
BRCA	-0.162
COAD
HGSC
ccRCC	0.068
GBM
HNSC	-0.502
LUAD	-1.047
LUSC
non_ccRCC	1.887
PDAC
UCEC	-0.245

TP53BP1-Ser1099
Cancer	Intensity
BRCA	-0.026
COAD	-0.791
HGSC	2.796
ccRCC	-0.009
GBM	-0.536
HNSC	-0.528
LUAD	-0.656
LUSC	-0.569
non_ccRCC	0.469
PDAC	-0.136
UCEC	-0.016

TP53BP1-Ser110
Cancer	Intensity
BRCA	1.172
COAD
HGSC	-1.547
ccRCC
GBM
HNSC
LUAD	-0.219
LUSC	0.235
non_ccRCC
PDAC
UCEC	0.359

TP53BP1-Ser1106
Cancer	Intensity
BRCA	-0.4
COAD	-1.116
HGSC	-0.312
ccRCC	0.547
GBM	-0.568
HNSC	-0.441
LUAD	-0.968
LUSC	-0.471
non_ccRCC	2.364
PDAC	0.704
UCEC	0.661

TP53BP1-Ser1109
Cancer	Intensity
BRCA
COAD	0.039
HGSC	-2.593
ccRCC	0.274
GBM	0.059
HNSC	0.319
LUAD
LUSC	0.217
non_ccRCC	0.798
PDAC	0.535
UCEC	0.352

TP53BP1-Ser1118
Cancer	Intensity
BRCA
COAD	-0.141
HGSC	-1.543
ccRCC	-1.102
GBM	0.247
HNSC	1.264
LUAD	-0.614
LUSC	0.464
non_ccRCC	-0.502
PDAC	1.68
UCEC	0.245

TP53BP1-Ser1119
Cancer	Intensity
BRCA
COAD	-0.086
HGSC	-2.266
ccRCC	0.103
GBM	0.966
HNSC	0.693
LUAD	0.411
LUSC
non_ccRCC
PDAC	-0.265
UCEC	0.442

TP53BP1-Ser1221
Cancer	Intensity
BRCA
COAD	0.707
HGSC
ccRCC
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1224
Cancer	Intensity
BRCA
COAD	0.707
HGSC
ccRCC
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser124
Cancer	Intensity
BRCA
COAD	0.494
HGSC	-1.151
ccRCC
GBM
HNSC
LUAD	0.657
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1293
Cancer	Intensity
BRCA
COAD	-1.016
HGSC	1.342
ccRCC
GBM	0.076
HNSC	-0.402
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1295
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1300
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1301
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser132
Cancer	Intensity
BRCA	0.744
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	-1.235
LUSC	0.878
non_ccRCC
PDAC
UCEC	-0.387

TP53BP1-Ser1322
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1325
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1327
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1347
Cancer	Intensity
BRCA
COAD
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.707

TP53BP1-Ser1367
Cancer	Intensity
BRCA
COAD	-0.307
HGSC	1.914
ccRCC	-0.145
GBM
HNSC	-0.147
LUAD	-1.067
LUSC
non_ccRCC
PDAC	-0.247
UCEC

TP53BP1-Ser1431
Cancer	Intensity
BRCA	0.246
COAD	0.043
HGSC	-2.497
ccRCC	0.213
GBM	0.159
HNSC	-0.014
LUAD	-0.134
LUSC	-0.797
non_ccRCC	1.417
PDAC	0.55
UCEC	0.816

TP53BP1-Ser1435
Cancer	Intensity
BRCA	-0.113
COAD	-0.034
HGSC	-2.759
ccRCC	0.293
GBM	0.398
HNSC	-0.001
LUAD	-0.361
LUSC	0.187
non_ccRCC	0.999
PDAC	0.705
UCEC	0.686

TP53BP1-Ser1467
Cancer	Intensity
BRCA
COAD	0.052
HGSC	-1.961
ccRCC	0.335
GBM
HNSC	0.235
LUAD	0.458
LUSC
non_ccRCC
PDAC
UCEC	0.88

TP53BP1-Ser1479
Cancer	Intensity
BRCA	1.04
COAD
HGSC
ccRCC	-0.431
GBM
HNSC	-0.965
LUAD	-0.754
LUSC
non_ccRCC
PDAC
UCEC	1.11

TP53BP1-Ser1485
Cancer	Intensity
BRCA
COAD
HGSC	-1.145
ccRCC
GBM
HNSC	0.704
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.441

TP53BP1-Ser1486
Cancer	Intensity
BRCA
COAD	-0.176
HGSC	-1.675
ccRCC
GBM	0.676
HNSC	0.499
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.676

TP53BP1-Ser1553
Cancer	Intensity
BRCA	-0.399
COAD	-0.09
HGSC	-1.597
ccRCC	-0.186
GBM	2.062
HNSC	-0.731
LUAD	0.544
LUSC
non_ccRCC	-0.011
PDAC
UCEC	0.406

TP53BP1-Ser1570
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC
UCEC	-0.707

TP53BP1-Ser1623
Cancer	Intensity
BRCA	0.109
COAD	0.706
HGSC	-0.313
ccRCC	0.633
GBM	-0.649
HNSC	-0.116
LUAD	-0.594
LUSC	-2.106
non_ccRCC
PDAC	1.333
UCEC	0.996

TP53BP1-Ser1636
Cancer	Intensity
BRCA	2.069
COAD
HGSC
ccRCC
GBM	-0.803
HNSC	0.499
LUAD	-0.343
LUSC	-0.484
non_ccRCC
PDAC	-0.596
UCEC	-0.341

TP53BP1-Ser1639
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.707

TP53BP1-Ser1640
Cancer	Intensity
BRCA
COAD	0.48
HGSC	-2.197
ccRCC
GBM	0.518
HNSC	-0.103
LUAD
LUSC	0.197
non_ccRCC	0.631
PDAC	0.473
UCEC

TP53BP1-Ser1647
Cancer	Intensity
BRCA
COAD	-0.281
HGSC	1.11
ccRCC	-0.829
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1648
Cancer	Intensity
BRCA
COAD
HGSC	1.462
ccRCC	-0.179
GBM	-0.704
HNSC	-0.579
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1649
Cancer	Intensity
BRCA
COAD	-0.509
HGSC	1.152
ccRCC
GBM	-0.643
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1650
Cancer	Intensity
BRCA
COAD	-0.045
HGSC	1.661
ccRCC
GBM	-0.557
HNSC	-0.1
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.959

TP53BP1-Ser1670
Cancer	Intensity
BRCA	-1.256
COAD
HGSC
ccRCC
GBM	1.05
HNSC	0.489
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.283

TP53BP1-Ser1678
Cancer	Intensity
BRCA	-0.443
COAD
HGSC
ccRCC	0.603
GBM
HNSC	0.93
LUAD	-1.54
LUSC	0.45
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1683
Cancer	Intensity
BRCA	-0.772
COAD	0.322
HGSC	1.65
ccRCC	-0.051
GBM	-0.095
HNSC	-0.488
LUAD	-1.952
LUSC	-0.351
non_ccRCC	1.276
PDAC	-0.344
UCEC	0.805

TP53BP1-Ser1691
Cancer	Intensity
BRCA
COAD
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser1706
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1710
Cancer	Intensity
BRCA	-1.394
COAD	0.841
HGSC	-0.038
ccRCC
GBM
HNSC	0.59
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1763
Cancer	Intensity
BRCA
COAD	-0.438
HGSC	-0.706
ccRCC
GBM
HNSC	1.144
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1764
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser1976
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser207
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-1.152
GBM
HNSC	0.647
LUAD	0.505
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser213
Cancer	Intensity
BRCA
COAD
HGSC	-1.494
ccRCC
GBM	0.482
HNSC
LUAD
LUSC	0.615
non_ccRCC
PDAC
UCEC	0.398

TP53BP1-Ser227
Cancer	Intensity
BRCA	-0.559
COAD	1.032
HGSC	-2.558
ccRCC	0.347
GBM	0.449
HNSC	-0.102
LUAD	-0.028
LUSC	0.4
non_ccRCC	-0.468
PDAC	1.106
UCEC	0.381

TP53BP1-Ser264
Cancer	Intensity
BRCA
COAD
HGSC	0.99
ccRCC	-0.182
GBM
HNSC	-0.921
LUAD	-0.976
LUSC
non_ccRCC
PDAC
UCEC	1.09

TP53BP1-Ser270
Cancer	Intensity
BRCA	-1.282
COAD	-0.547
HGSC	0.337
ccRCC	0.598
GBM	-1.076
HNSC	-0.407
LUAD	-0.065
LUSC	0.122
non_ccRCC	2.428
PDAC	-0.468
UCEC	0.359

TP53BP1-Ser285
Cancer	Intensity
BRCA	1.685
COAD
HGSC
ccRCC	-0.745
GBM	1.526
HNSC	-0.932
LUAD	-0.956
LUSC	-0.513
non_ccRCC	0.35
PDAC	-0.309
UCEC	-0.105

TP53BP1-Ser292
Cancer	Intensity
BRCA
COAD	-1.068
HGSC
ccRCC	0.155
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC	0.914
UCEC

TP53BP1-Ser299
Cancer	Intensity
BRCA	0.87
COAD	-0.078
HGSC	-2.675
ccRCC	-0.093
GBM	-0.102
HNSC	0.366
LUAD	0.294
LUSC
non_ccRCC	0.809
PDAC	0.331
UCEC	0.278

TP53BP1-Ser306
Cancer	Intensity
BRCA	0.988
COAD
HGSC	-2.119
ccRCC	-0.082
GBM	0.471
HNSC	0.168
LUAD
LUSC
non_ccRCC
PDAC	0.523
UCEC	0.051

TP53BP1-Ser315
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	-0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser320
Cancer	Intensity
BRCA
COAD
HGSC	-1.367
ccRCC
GBM
HNSC
LUAD	0.823
LUSC	-0.12
non_ccRCC
PDAC
UCEC	0.664

TP53BP1-Ser321
Cancer	Intensity
BRCA
COAD	0.049
HGSC	-1.635
ccRCC
GBM
HNSC
LUAD	1.072
LUSC	0.111
non_ccRCC
PDAC
UCEC	0.404

TP53BP1-Ser328
Cancer	Intensity
BRCA
COAD	0.516
HGSC	-1.499
ccRCC
GBM
HNSC
LUAD	0.462
LUSC
non_ccRCC
PDAC
UCEC	0.521

TP53BP1-Ser338
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser354
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC	-0.707
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser364
Cancer	Intensity
BRCA
COAD	0.056
HGSC	-1.97
ccRCC	0.135
GBM
HNSC	0.748
LUAD	0.568
LUSC
non_ccRCC
PDAC
UCEC	0.463

TP53BP1-Ser365
Cancer	Intensity
BRCA
COAD	0.194
HGSC	-2.17
ccRCC	0.331
GBM	0.514
HNSC	0.459
LUAD	-0.134
LUSC
non_ccRCC
PDAC
UCEC	0.807

TP53BP1-Ser371
Cancer	Intensity
BRCA
COAD	0.363
HGSC	-2.39
ccRCC	0.224
GBM	0.432
HNSC	0.282
LUAD	0.45
LUSC	0.787
non_ccRCC	-1.185
PDAC	0.322
UCEC	0.716

TP53BP1-Ser384
Cancer	Intensity
BRCA
COAD	-0.738
HGSC	-1.53
ccRCC	0.308
GBM	0.046
HNSC	1.09
LUAD	-0.451
LUSC
non_ccRCC
PDAC
UCEC	1.275

TP53BP1-Ser385
Cancer	Intensity
BRCA
COAD	-0.386
HGSC	-0.687
ccRCC	-1.022
GBM	0.177
HNSC	1.595
LUAD
LUSC
non_ccRCC	-1.225
PDAC	0.946
UCEC	0.602

TP53BP1-Ser400
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC	0.404
LUAD	-1.139
LUSC
non_ccRCC
PDAC
UCEC	0.735

TP53BP1-Ser403
Cancer	Intensity
BRCA	-0.985
COAD	-0.068
HGSC	1.876
ccRCC	-0.131
GBM	-0.285
HNSC	0.06
LUAD	-1.371
LUSC	-0.905
non_ccRCC	1.623
PDAC	0.257
UCEC	-0.07

TP53BP1-Ser498
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.707
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser505
Cancer	Intensity
BRCA	-0.037
COAD	0.014
HGSC	-2.9
ccRCC	0.331
GBM	0.067
HNSC	0.367
LUAD	0.392
LUSC	0.005
non_ccRCC	0.902
PDAC	0.485
UCEC	0.375

TP53BP1-Ser512
Cancer	Intensity
BRCA	1.485
COAD	0.489
HGSC	-0.63
ccRCC	0.023
GBM	0.487
HNSC	1.573
LUAD	0.259
LUSC	-0.106
non_ccRCC	-1.184
PDAC	-0.978
UCEC	-1.417

TP53BP1-Ser517
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser523
Cancer	Intensity
BRCA
COAD
HGSC	-0.69
ccRCC	0.759
GBM
HNSC	0.019
LUAD	-1.257
LUSC
non_ccRCC
PDAC
UCEC	1.17

TP53BP1-Ser525
Cancer	Intensity
BRCA
COAD	0.506
HGSC	0.654
ccRCC	0.077
GBM	-2.217
HNSC	0.145
LUAD	0.301
LUSC
non_ccRCC
PDAC
UCEC	0.535

TP53BP1-Ser528
Cancer	Intensity
BRCA
COAD	-0.171
HGSC	-1.639
ccRCC	-0.136
GBM	0.779
HNSC	-0.185
LUAD	-0.644
LUSC	2.069
non_ccRCC	0.763
PDAC	-0.411
UCEC	-0.425

TP53BP1-Ser530
Cancer	Intensity
BRCA	-0.036
COAD	0.178
HGSC	-1.733
ccRCC	0.596
GBM	0.017
HNSC	0.345
LUAD	-1.451
LUSC	-0.164
non_ccRCC	2.072
PDAC	0.245
UCEC	-0.069

TP53BP1-Ser535
Cancer	Intensity
BRCA
COAD
HGSC	1.018
ccRCC
GBM	-0.981
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.037

TP53BP1-Ser537
Cancer	Intensity
BRCA
COAD
HGSC	0.707
ccRCC
GBM	-0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser557
Cancer	Intensity
BRCA	0.648
COAD	-0.154
HGSC	-2.781
ccRCC	0.241
GBM	-0.252
HNSC	0.948
LUAD	-0.18
LUSC	0.094
non_ccRCC	0.681
PDAC	0.458
UCEC	0.296

TP53BP1-Ser571
Cancer	Intensity
BRCA	-0.576
COAD	1.754
HGSC	-0.006
ccRCC	-0.236
GBM	-1.184
HNSC	0.071
LUAD	-0.992
LUSC	-0.507
non_ccRCC	0.32
PDAC	1.875
UCEC	-0.519

TP53BP1-Ser585
Cancer	Intensity
BRCA	0.535
COAD	-1.562
HGSC	-1.703
ccRCC	0.742
GBM	-0.353
HNSC	-0.287
LUAD	-0.472
LUSC	0.187
non_ccRCC	1.433
PDAC	1.064
UCEC	0.415

TP53BP1-Ser603
Cancer	Intensity
BRCA
COAD
HGSC	1.323
ccRCC	-0.58
GBM	-0.26
HNSC
LUAD
LUSC	-1.028
non_ccRCC	-0.475
PDAC	1.521
UCEC	-0.501

TP53BP1-Ser635
Cancer	Intensity
BRCA
COAD
HGSC	-1.368
ccRCC	-0.486
GBM	1.411
HNSC	0.686
LUAD
LUSC
non_ccRCC	0.327
PDAC
UCEC	-0.57

TP53BP1-Ser640
Cancer	Intensity
BRCA	-0.305
COAD
HGSC	-1.283
ccRCC
GBM
HNSC
LUAD	0.827
LUSC
non_ccRCC
PDAC
UCEC	0.76

TP53BP1-Ser644
Cancer	Intensity
BRCA	-1.334
COAD	0.02
HGSC	-1.641
ccRCC	-0.056
GBM	0.081
HNSC	0.04
LUAD	0.851
LUSC
non_ccRCC
PDAC	1.617
UCEC	0.421

TP53BP1-Ser645
Cancer	Intensity
BRCA	-1.351
COAD	0.124
HGSC	-1.73
ccRCC	-0.073
GBM	0.456
HNSC	0.134
LUAD	0.53
LUSC
non_ccRCC
PDAC	1.6
UCEC	0.31

TP53BP1-Ser664
Cancer	Intensity
BRCA	-1.928
COAD
HGSC
ccRCC	0.231
GBM	-1.015
HNSC	0.184
LUAD	0.689
LUSC
non_ccRCC	0.698
PDAC	0.045
UCEC	1.095

TP53BP1-Ser665
Cancer	Intensity
BRCA	-1.928
COAD
HGSC
ccRCC	0.231
GBM	-1.015
HNSC	0.184
LUAD	0.689
LUSC
non_ccRCC	0.698
PDAC	0.045
UCEC	1.095

TP53BP1-Ser667
Cancer	Intensity
BRCA	-1.933
COAD
HGSC
ccRCC	0.323
GBM	-1.024
HNSC	0.17
LUAD	0.673
LUSC
non_ccRCC	0.682
PDAC	0.032
UCEC	1.078

TP53BP1-Ser679
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.707
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser68
Cancer	Intensity
BRCA	0.987
COAD	-2.012
HGSC	-1.715
ccRCC	0.437
GBM	0.453
HNSC	-0.118
LUAD	-0.346
LUSC	0.676
non_ccRCC	0.387
PDAC	0.38
UCEC	0.871

TP53BP1-Ser697
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC	-0.055
LUAD	-1.182
LUSC	1.264
non_ccRCC	-0.027
PDAC
UCEC

TP53BP1-Ser718
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.707
GBM
HNSC	-0.707
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser726
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.447
GBM	1.442
HNSC	0.504
LUAD	-0.336
LUSC
non_ccRCC
PDAC
UCEC	-1.163

TP53BP1-Ser729
Cancer	Intensity
BRCA
COAD	-0.13
HGSC	-2.257
ccRCC	0.179
GBM	-0.219
HNSC	0.587
LUAD	0.141
LUSC	0.884
non_ccRCC
PDAC
UCEC	0.814

TP53BP1-Ser732
Cancer	Intensity
BRCA	-0.208
COAD	0.142
HGSC	-2.711
ccRCC	0.191
GBM	-0.037
HNSC	0.05
LUAD	0.206
LUSC	0.05
non_ccRCC	0.327
PDAC	1.45
UCEC	0.541

TP53BP1-Ser770
Cancer	Intensity
BRCA	0.423
COAD
HGSC
ccRCC	-0.747
GBM
HNSC
LUAD	-0.37
LUSC
non_ccRCC	-0.983
PDAC	1.775
UCEC	-0.098

TP53BP1-Ser776
Cancer	Intensity
BRCA	0.271
COAD	0.765
HGSC	-2.79
ccRCC	0.158
GBM	-0.191
HNSC	-0.218
LUAD	0.138
LUSC	-0.044
non_ccRCC	0.472
PDAC	1.01
UCEC	0.428

TP53BP1-Ser787
Cancer	Intensity
BRCA
COAD	-0.707
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Ser789
Cancer	Intensity
BRCA
COAD	-0.416
HGSC	-0.725
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	1.141

TP53BP1-Ser791
Cancer	Intensity
BRCA
COAD	-0.396
HGSC	-0.758
ccRCC	-0.504
GBM	-0.548
HNSC
LUAD	-0.418
LUSC
non_ccRCC	0.571
PDAC
UCEC	2.053

TP53BP1-Ser814
Cancer	Intensity
BRCA	1.193
COAD	0.263
HGSC	-1.342
ccRCC	0.174
GBM	0.512
HNSC	-0.612
LUAD	0.029
LUSC	-1.749
non_ccRCC	1.038
PDAC	1.19
UCEC	-0.696

TP53BP1-Ser83
Cancer	Intensity
BRCA	-1.09
COAD
HGSC	0.998
ccRCC
GBM	0.683
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.591

TP53BP1-Ser835
Cancer	Intensity
BRCA
COAD	0.165
HGSC	-2.217
ccRCC	0.396
GBM	0.155
HNSC	0.71
LUAD	0.221
LUSC
non_ccRCC
PDAC
UCEC	0.57

TP53BP1-Ser836
Cancer	Intensity
BRCA	-0.736
COAD	0.068
HGSC	-2.686
ccRCC	0.772
GBM	0.974
HNSC	0.564
LUAD	0.065
LUSC	0.48
non_ccRCC	0.333
PDAC	-0.008
UCEC	0.173

TP53BP1-Ser839
Cancer	Intensity
BRCA	-0.583
COAD	-0.188
HGSC	-2.68
ccRCC	1.035
GBM	0.581
HNSC	0.651
LUAD	0.173
LUSC	0.34
non_ccRCC	0.331
PDAC	-0.215
UCEC	0.556

TP53BP1-Ser865
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.191
GBM	0.78
HNSC	0.126
LUAD	-1.599
LUSC
non_ccRCC
PDAC
UCEC	0.885

TP53BP1-Ser867
Cancer	Intensity
BRCA	-0.274
COAD	-0.662
HGSC	-2.153
ccRCC	0.879
GBM	1.09
HNSC	0.043
LUAD	-0.521
LUSC	-0.128
non_ccRCC
PDAC	0.631
UCEC	1.096

TP53BP1-Ser872
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Ser980
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	0.791
HNSC	-1.124
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.333

TP53BP1-Thr1060
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM	1.029
HNSC	-0.968
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-0.062

TP53BP1-Thr1061
Cancer	Intensity
BRCA
COAD	-0.269
HGSC	-0.937
ccRCC
GBM	1.254
HNSC	-0.884
LUAD	0.836
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1127
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1297
Cancer	Intensity
BRCA
COAD	-0.984
HGSC
ccRCC
GBM	1.016
HNSC	-0.032
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1324
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1377
Cancer	Intensity
BRCA
COAD
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.707

TP53BP1-Thr1547
Cancer	Intensity
BRCA
COAD
HGSC	-0.366
ccRCC	1.421
GBM
HNSC	-0.908
LUAD	-0.148
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1550
Cancer	Intensity
BRCA
COAD	0.132
HGSC
ccRCC	0.349
GBM	1.279
HNSC	-1.462
LUAD	-0.298
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr1614
Cancer	Intensity
BRCA	-1.431
COAD	0.67
HGSC	-0.485
ccRCC	-0.788
GBM	2.021
HNSC	0.49
LUAD	0.36
LUSC	-1.166
non_ccRCC	-0.522
PDAC	0.109
UCEC	0.741

TP53BP1-Thr1643
Cancer	Intensity
BRCA	0.854
COAD	0.392
HGSC	-2.863
ccRCC	-0.177
GBM	0.33
HNSC	-0.216
LUAD	0.109
LUSC	0.262
non_ccRCC	0.662
PDAC	0.352
UCEC	0.295

TP53BP1-Thr1645
Cancer	Intensity
BRCA
COAD
HGSC	1.376
ccRCC	-0.165
GBM
HNSC	-0.191
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-1.021

TP53BP1-Thr1677
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.498
GBM
HNSC	0.653
LUAD	-1.151
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr210
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.953
GBM	-0.14
HNSC	1.405
LUAD	-0.312
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr307
Cancer	Intensity
BRCA	1.201
COAD
HGSC	-1.731
ccRCC	-0.4
GBM	0.405
HNSC
LUAD
LUSC
non_ccRCC
PDAC	0.485
UCEC	0.041

TP53BP1-Thr326
Cancer	Intensity
BRCA
COAD	0.178
HGSC	-1.077
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	0.899

TP53BP1-Thr339
Cancer	Intensity
BRCA
COAD
HGSC	-1.059
ccRCC
GBM
HNSC
LUAD	0.928
LUSC
non_ccRCC
PDAC
UCEC	0.131

TP53BP1-Thr362
Cancer	Intensity
BRCA
COAD	-0.707
HGSC
ccRCC	-1.347
GBM	0.87
HNSC	0.983
LUAD	-0.585
LUSC
non_ccRCC
PDAC
UCEC	0.787

TP53BP1-Thr387
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr514
Cancer	Intensity
BRCA
COAD	-1.013
HGSC
ccRCC
GBM
HNSC
LUAD	0.987
LUSC
non_ccRCC
PDAC
UCEC	0.026

TP53BP1-Thr524
Cancer	Intensity
BRCA
COAD
HGSC	-1.647
ccRCC	1.11
GBM	0.732
HNSC	0.067
LUAD	-0.62
LUSC
non_ccRCC
PDAC
UCEC	0.358

TP53BP1-Thr548
Cancer	Intensity
BRCA
COAD	-0.553
HGSC
ccRCC	-0.852
GBM	-1.152
HNSC	1.36
LUAD	-0.873
LUSC
non_ccRCC	1.18
PDAC	0.793
UCEC	0.098

TP53BP1-Thr553
Cancer	Intensity
BRCA	-0.948
COAD	-0.216
HGSC	2.491
ccRCC	-0.337
GBM	-0.276
HNSC	-0.039
LUAD	-0.644
LUSC
non_ccRCC
PDAC	0.332
UCEC	-0.364

TP53BP1-Thr596
Cancer	Intensity
BRCA	-1.264
COAD
HGSC	0.457
ccRCC	1.146
GBM	0.685
HNSC
LUAD	-1.219
LUSC	-0.575
non_ccRCC
PDAC
UCEC	0.77

TP53BP1-Thr598
Cancer	Intensity
BRCA
COAD	0.967
HGSC	0.99
ccRCC	0.746
GBM
HNSC
LUAD	-0.811
LUSC	-0.748
non_ccRCC
PDAC
UCEC	-1.145

TP53BP1-Thr625
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.906
GBM
HNSC	1.073
LUAD	-0.167
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr675
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.98
GBM	0.038
HNSC	-1.019
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr725
Cancer	Intensity
BRCA
COAD
HGSC	-1.498
ccRCC	0.475
GBM
HNSC	0.571
LUAD	0.452
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr860
Cancer	Intensity
BRCA
COAD
HGSC	1.149
ccRCC	-0.674
GBM
HNSC
LUAD
LUSC	-0.475
non_ccRCC
PDAC
UCEC

TP53BP1-Thr924
Cancer	Intensity
BRCA
COAD	0.049
HGSC	0.024
ccRCC	-1.129
GBM	1.767
HNSC	-0.772
LUAD	0.06
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Thr927
Cancer	Intensity
BRCA	0.42
COAD	-0.541
HGSC	1.114
ccRCC	-0.931
GBM	-1.874
HNSC	-1.072
LUAD	0.146
LUSC	0.75
non_ccRCC	1.404
PDAC	0.431
UCEC	0.152

TP53BP1-Tyr1610
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	1.408
GBM
HNSC	-0.86
LUAD	-0.528
LUSC
non_ccRCC
PDAC
UCEC	-0.02

TP53BP1-Tyr209
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.81
GBM	-0.249
HNSC	1.457
LUAD	-0.399
LUSC
non_ccRCC
PDAC
UCEC

TP53BP1-Tyr527
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	0.475
GBM	0.028
HNSC	-0.762
LUAD	-1.128
LUSC
non_ccRCC
PDAC
UCEC	1.386

TP53BP1-Tyr817
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser302
Cancer	Intensity
BRCA	-1.124
COAD
HGSC
ccRCC	-0.566
GBM	-0.494
HNSC
LUAD	0.091
LUSC	0.149
non_ccRCC	0.005
PDAC	2.247
UCEC	-0.308

TP53BP2-Ser464
Cancer	Intensity
BRCA	0.527
COAD
HGSC	-2.253
ccRCC	-0.128
GBM
HNSC	0.072
LUAD	-0.304
LUSC	0.592
non_ccRCC	0.56
PDAC	0.933
UCEC

TP53BP2-Ser486
Cancer	Intensity
BRCA	1.276
COAD	0.133
HGSC	-0.092
ccRCC	0.2
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC	-1.518

TP53BP2-Ser487
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser562
Cancer	Intensity
BRCA
COAD	0.933
HGSC	-1.471
ccRCC
GBM
HNSC	0.591
LUAD	0.528
LUSC
non_ccRCC	-0.582
PDAC
UCEC

TP53BP2-Ser564
Cancer	Intensity
BRCA
COAD	0.707
HGSC	-0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser567
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC
GBM
HNSC	0.707
LUAD	-0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser575
Cancer	Intensity
BRCA
COAD
HGSC	-2.416
ccRCC
GBM	0.138
HNSC	0.568
LUAD	0.429
LUSC	0.408
non_ccRCC	-0.08
PDAC	0.404
UCEC	0.549

TP53BP2-Ser578
Cancer	Intensity
BRCA	1.05
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	-0.11
LUSC	-0.941
non_ccRCC
PDAC
UCEC

TP53BP2-Ser582
Cancer	Intensity
BRCA	-0.722
COAD
HGSC	2.745
ccRCC	-0.233
GBM	-0.056
HNSC	-0.16
LUAD	-0.307
LUSC	-0.097
non_ccRCC	-0.8
PDAC	-0.03
UCEC	-0.34

TP53BP2-Ser704
Cancer	Intensity
BRCA
COAD	0.146
HGSC	2.094
ccRCC	-0.259
GBM	-0.32
HNSC	0.017
LUAD
LUSC
non_ccRCC
PDAC	-0.921
UCEC	-0.758

TP53BP2-Ser720
Cancer	Intensity
BRCA	-1.018
COAD
HGSC	-1.714
ccRCC	0.383
GBM	-0.221
HNSC	0.064
LUAD	0.02
LUSC	0.356
non_ccRCC	2.135
PDAC	0.262
UCEC	-0.267

TP53BP2-Ser742
Cancer	Intensity
BRCA
COAD	-0.707
HGSC
ccRCC
GBM	0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53BP2-Ser743
Cancer	Intensity
BRCA
COAD	-0.207
HGSC	0.596
ccRCC	-0.287
GBM	0.08
HNSC	-1.59
LUAD
LUSC	1.409
non_ccRCC
PDAC
UCEC

TP53BP2-Ser789
Cancer	Intensity
BRCA
COAD
HGSC	-1.164
ccRCC
GBM	0.336
HNSC	0.998
LUAD
LUSC	-0.714
non_ccRCC
PDAC	-0.697
UCEC	1.241

TP53BP2-Thr573
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-1.078
GBM
HNSC	1.195
LUAD	-0.506
LUSC
non_ccRCC
PDAC
UCEC	0.389

TP53BP2-Thr592
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.237
GBM
HNSC
LUAD	-0.622
LUSC
non_ccRCC	1.718
PDAC	-0.773
UCEC	-0.085

TP53BP2-Thr745
Cancer	Intensity
BRCA
COAD
HGSC
ccRCC	-0.707
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC	0.707
UCEC

TP53I11-Ser14
Cancer	Intensity
BRCA	-1.268
COAD	0.477
HGSC	1.815
ccRCC	0.355
GBM	-0.192
HNSC	0.761
LUAD	-0.233
LUSC	0.795
non_ccRCC	-1.777
PDAC	-0.274
UCEC	-0.459

TP53I11-Ser20
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53I11-Ser45
Cancer	Intensity
BRCA	-0.707
COAD
HGSC
ccRCC
GBM
HNSC
LUAD	0.707
LUSC
non_ccRCC
PDAC
UCEC

TP53I11-Thr16
Cancer	Intensity
BRCA
COAD	-0.707
HGSC	0.707
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC

TP53INP2-Ser14
Cancer	Intensity
BRCA
COAD	1.043
HGSC
ccRCC
GBM
HNSC	0.065
LUAD
LUSC	0.25
non_ccRCC
PDAC
UCEC	-1.358

PTM-Disease Association:

source: PTMD

Residue	Position	State	Disease	Class	PMID
S	15	A	Breast cancer/tumor/carcinoma	Phosphorylation	23798621
S	15	D	Ataxia-telangiectasia	Phosphorylation	9733515
S	15	D	Brain cancer	Phosphorylation	23268709
S	15	D	Breast cancer/tumor/carcinoma	Phosphorylation	15958581
S	15	P	Prostate cancer/carcinoma/adenocarcinoma	Phosphorylation	23359208
S	15	U	Down syndrome	Phosphorylation	20696760
S	15	U	Hepatocellular carcinoma	Phosphorylation	22030623
S	15	U	Neuroblastoma	Phosphorylation	23824039
S	15	U	Colorectal cancer	Phosphorylation	25860929

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb