| Id: | acc3077 |
| Group: | 2sens |
| Protein: | mTOR |
| Gene Symbol: | Mtor |
| Protein Id: | Q9JLN9 |
| Protein Name: | MTOR_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser1448 |
| Site Sequence: | HFGELEIQATWYEKLHEWEDA |
| Disease Category: | Cancer |
| Disease: | Cancer |
| Disease Subtype: | |
| Disease Cellline: | "MCF-7,T98G,U87MG,K-562,CEM T" |
| Disease Info: | |
| Drug: | AICAR |
| Drug Info: | "AICAR is a drug that has been studied for its potential in various medical applications, including its effects on metabolism." |
| Effect: | modulate |
| Effect Info: | "AICAR activates AMPK, inhibits Akt phosphorylation, blocks the cell cycle, and inhibits the proliferation of tumor cells." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 16176927 |
| Sentence Index: | 16176927_4-5 |
| Sentence: | "Anti-proliferative effect of AICAR is mediated through activated AMP-activated protein kinase (AMPK) as iodotubericidin and dominant-negative AMPK expression vector reversed the AICAR-mediated growth arrest. Moreover, constitutive active AMPK arrested the cells in S-phase by inducing the expression of p21, p27, and p53 proteins and inhibiting Akt phosphorylation, suggesting the involvement of AMPK." |
Sequence & Structure:
MLGTGPAVATASAATSSNVSVLQQFASGLKSRNEETRAKAAKELQHYVTMELREMSQEESTRFYDQLNHHIFELVSSSDANERKGGILAIASLIGVEGGNSTRIGRFANYLRNLLPSSDPVVMEMASKAIGRLAMAGDTFTAEYVEFEVKRALEWLGADRNEGRRHAAVLVLRELAISVPTFFFQQVQPFFDNIFVAVWDPKQAIREGAVAALRACLILTTQREPKEMQKPQWYRHTFEEAEKGFDETLAKEKGMNRDDRIHGALLILNELVRISSMEGERLREEMEEITQQQLVHDKYCKDLMGFGTKPRHITPFTSFQAVQPQQPNALVGLLGYSSPQGLMGFGTSPSPAKSTLVESRCCRDLMEEKFDQVCQWVLKCRSSKNSLIQMTILNLLPRLAAFRPSAFTDTQYLQDTMNHVLSCVKKEKERTAAFQALGLLSVAVRSEFKVYLPRVLDIIRAALPPKDFAHKRQKTVQVDATVFTCISMLARAMGPGIQQDIKELLEPMLAVGLSPALTAVLYDLSRQIPQLKKDIQDGLLKMLSLVLMHKPLRHPGMPKGLAHQLASPGLTTLPEASDVASITLALRTLGSFEFEGHSLTQFVRHCADHFLNSEHKEIRMEAARTCSRLLTPSIHLISGHAHVVSQTAVQVVADVLSKLLVVGITDPDPDIRYCVLASLDERFDAHLAQAENLQALFVALNDQVFEIRELAICTVGRLSSMNPAFVMPFLRKMLIQILTELEHSGIGRIKEQSARMLGHLVSNAPRLIRPYMEPILKALILKLKDPDPDPNPGVINNVLATIGELAQVSGLEMRKWVDELFIIIMDMLQDSSLLAKRQVALWTLGQLVASTGYVVEPYRKYPTLLEVLLNFLKTEQNQGTRREAIRVLGLLGALDPYKHKVNIGMIDQSRDASAVSLSESKSSQDSSDYSTSEMLVNMGNLPLDEFYPAVSMVALMRIFRDQSLSHHHTMVVQAITFIFKSLGLKCVQFLPQVMPTFLNVIRVCDGAIREFLFQQLGMLVSFVKSHIRPYMDEIVTLMREFWVMNTSIQSTIILLIEQIVVALGGEFKLYLPQLIPHMLRVFMHDNSQGRIVSIKLLAAIQLFGANLDDYLHLLLPPIVKLFDAPEVPLPSRKAALETVDRLTESLDFTDYASRIIHPIVRTLDQSPELRSTAMDTLSSLVFQLGKKYQIFIPMVNKVLVRHRINHQRYDVLICRIVKGYTLADEEEDPLIYQHRMLRSSQGDALASGPVETGPMKKLHVSTINLQKAWGAARRVSKDDWLEWLRRLSLELLKDSSSPSLRSCWALAQAYNPMARDLFNAAFVSCWSELNEDQQDELIRSIELALTSQDIAEVTQTLLNLAEFMEHSDKGPLPLRDDNGIVLLGERAAKCRAYAKALHYKELEFQKGPTPAILESLISINNKLQQPEAASGVLEYAMKHFGELEIQATWYEKLHEWEDALVAYDKKMDTNKEDPELMLGRMRCLEALGEWGQLHQQCCEKWTLVNDETQAKMARMAAAAAWGLGQWDSMEEYTCMIPRDTHDGAFYRAVLALHQDLFSLAQQCIDKARDLLDAELTAMAGESYSRAYGAMVSCHMLSELEEVIQYKLVPERREIIRQIWWERLQGCQRIVEDWQKILMVRSLVVSPHEDMRTWLKYASLCGKSGRLALAHKTLVLLLGVDPSRQLDHPLPTAHPQVTYAYMKNMWKSARKIDAFQHMQHFVQTMQQQAQHAIATEDQQHKQELHKLMARCFLKLGEWQLNLQGINESTIPKVLQYYSAATEHDRSWYKAWHAWAVMNFEAVLHYKHQNQARDEKKKLRHASGANITNATTAATTAASAAAATSTEGSNSESEAESNENSPTPSPLQKKVTEDLSKTLLLYTVPAVQGFFRSISLSRGNNLQDTLRVLTLWFDYGHWPDVNEALVEGVKAIQIDTWLQVIPQLIARIDTPRPLVGRLIHQLLTDIGRYHPQALIYPLTVASKSTTTARHNAANKILKNMCEHSNTLVQQAMMVSEELIRVAILWHEMWHEGLEEASRLYFGERNVKGMFEVLEPLHAMMERGPQTLKETSFNQAYGRDLMEAQEWCRKYMKSGNVKDLTQAWDLYYHVFRRISKQLPQLTSLELQYVSPKLLMCRDLELAVPGTYDPNQPIIRIQSIAPSLQVITSKQRPRKLTLMGSNGHEFVFLLKGHEDLRQDERVMQLFGLVNTLLANDPTSLRKNLSIQRYAVIPLSTNSGLIGWVPHCDTLHALIRDYREKKKILLNIEHRIMLRMAPDYDHLTLMQKVEVFEHAVNNTAGDDLAKLLWLKSPSSEVWFDRRTNYTRSLAVMSMVGYILGLGDRHPSNLMLDRLSGKILHIDFGDCFEVAMTREKFPEKIPFRLTRMLTNAMEVTGLDGNYRTTCHTVMEVLREHKDSVMAVLEAFVYDPLLNWRLMDTNTKGNKRSRTRTDSYSAGQSVEILDGVELGEPAHKKAGTTVPESIHSFIGDGLVKPEALNKKAIQIINRVRDKLTGRDFSHDDTLDVPTQVELLIKQATSHENLCQCYIGWCPFW
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| LAMTOR1-Ser26 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 1.845 |
| ccRCC | -0.597 |
| GBM | -1.093 |
| HNSC | -0.132 |
| LUAD | 0.104 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.127 |
| LAMTOR1-Ser27 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.43 |
| HGSC | 1.255 |
| ccRCC | 0.561 |
| GBM | -0.93 |
| HNSC | |
| LUAD | -1.876 |
| LUSC | 1.123 |
| non_ccRCC | -0.49 |
| PDAC | -0.168 |
| UCEC | 0.095 |
| LAMTOR1-Ser42 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.514 |
| HGSC | 1.958 |
| ccRCC | -0.313 |
| GBM | -0.846 |
| HNSC | 0.01 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.294 |
| LAMTOR1-Ser45 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.93 |
| ccRCC | -1.39 |
| GBM | 0.448 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.012 |
| LAMTOR1-Ser56 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.128 |
| HGSC | 0.887 |
| ccRCC | |
| GBM | |
| HNSC | 0.41 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | -1.425 |
| UCEC | |
| LAMTOR1-Ser63 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.037 |
| HGSC | -1.018 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.981 |
| LAMTOR1-Ser69 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | -0.707 |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| LAMTOR1-Ser73 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| LAMTOR1-Ser98 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.738 |
| HGSC | 1.741 |
| ccRCC | 0.592 |
| GBM | 0.016 |
| HNSC | -1.316 |
| LUAD | 0.238 |
| LUSC | -0.534 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| LAMTOR1-Thr30 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| LAMTOR1-Thr48 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.801 |
| COAD | -0.051 |
| HGSC | |
| ccRCC | 0.377 |
| GBM | |
| HNSC | -0.711 |
| LUAD | -0.263 |
| LUSC | -0.615 |
| non_ccRCC | 2.064 |
| PDAC | |
| UCEC | |
| LAMTOR1-Tyr40 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.514 |
| ccRCC | 1.011 |
| GBM | 0.093 |
| HNSC | -1.138 |
| LUAD | 0.832 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.311 |
| LAMTOR5-Ser108 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 1.07 |
| LUAD | |
| LUSC | |
| non_ccRCC | -0.159 |
| PDAC | |
| UCEC | -0.911 |
| LAMTOR5-Ser99 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.021 |
| GBM | |
| HNSC | |
| LUAD | 0.52 |
| LUSC | |
| non_ccRCC | -1.391 |
| PDAC | |
| UCEC | 0.892 |
| LAMTOR5-Thr106 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.86 |
| GBM | |
| HNSC | 0.912 |
| LUAD | -0.871 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.819 |
| MTOR-Ser1261 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.465 |
| HGSC | 2.522 |
| ccRCC | -0.319 |
| GBM | -0.598 |
| HNSC | -0.808 |
| LUAD | 0.156 |
| LUSC | -0.184 |
| non_ccRCC | 0.799 |
| PDAC | -0.601 |
| UCEC | -0.503 |
| MTOR-Ser2448 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| MTOR-Ser2478 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.378 |
| COAD | 0.388 |
| HGSC | |
| ccRCC | 0.311 |
| GBM | -0.144 |
| HNSC | 0.355 |
| LUAD | 0.727 |
| LUSC | 0.556 |
| non_ccRCC | -0.949 |
| PDAC | -0.435 |
| UCEC | -2.186 |
| MTOR-Ser2481 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.302 |
| COAD | -0.364 |
| HGSC | 2.451 |
| ccRCC | -0.257 |
| GBM | 0.596 |
| HNSC | -0.341 |
| LUAD | -0.327 |
| LUSC | 0.493 |
| non_ccRCC | -1.381 |
| PDAC | -0.206 |
| UCEC | -0.964 |
| MTOR-Ser567 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.124 |
| HNSC | 0.653 |
| LUAD | 0.673 |
| LUSC | -1.451 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| MTOR-Thr1262 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| MTOR-Tyr2449 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
