| Id: | acc3079 |
| Group: | 2sens |
| Protein: | Wwox |
| Gene Symbol: | WWOX |
| Protein Id: | Q9NZC7 |
| Protein Name: | WWOX_HUMAN |
| PTM: | phosphorylation |
| Site: | Tyr287 |
| Site Sequence: | SRLSPTKNDYWAMLAYNRSKL |
| Disease Category: | Cancer |
| Disease: | Prostate Cancer |
| Disease Subtype: | |
| Disease Cellline: | LNCaP |
| Disease Info: | |
| Drug: | geldanamycin |
| Drug Info: | Geldanamycin is a benzoquinone ansamycin antibiotic. It has potential anti - tumor activities. |
| Effect: | modulate |
| Effect Info: | Treatment of cells with the Hsp90 inhibitor geldanamycin inhibits Ack1 kinase activity and suppresses tumorigenesis. Activated Ack1 mainly phosphorylates Wwox at the Tyr287 site. Ack1 stimulates prostate tumorigenesis in part by negatively regulating the pro - apoptotic tumor suppressor Wwox. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 16288044 |
| Sentence Index: | 16288044_10-11 |
| Sentence: | "Site-directed mutagenesis revealed that activated Ack1 primarily phosphorylated Wwox at Tyr287, suggesting that phosphorylation of distinct tyrosine residues activate or degrade Wwox. Primary androgen-independent prostate tumors but not benign prostate showed increased tyrosine-phosphorylated Ack1 and decreased Wwox." |
Sequence & Structure:
MAALRYAGLDDTDSEDELPPGWEERTTKDGWVYYANHTEEKTQWEHPKTGKRKRVAGDLPYGWEQETDENGQVFFVDHINKRTTYLDPRLAFTVDDNPTKPTTRQRYDGSTTAMEILQGRDFTGKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKAKVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQVNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAMLAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPGNMMYSNIHRSWWVYTLLFTLARPFTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLIQERLGSQSG
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
