| Id: | acc3080 |
| Group: | 2sens |
| Protein: | DARPP-32 |
| Gene Symbol: | Ppp1r1b |
| Protein Id: | Q6J4I0 |
| Protein Name: | PPR1B_RAT |
| PTM: | phosphorylation |
| Site: | Thr34 |
| Site Sequence: | VEMIRRRRPTPALLFRVSEHS |
| Disease Category: | Other |
| Disease: | Cell Signaling |
| Disease Subtype: | |
| Disease Cellline: | PC-12/rNPFF1 |
| Disease Info: | |
| Drug: | PFR(Tic)amide + forskolin |
| Drug Info: | PFR(Tic)amide is a drug that may have potential pharmacological effects. It can be used in relevant medical treatments. |
| Effect: | no effect |
| Effect Info: | PFR(Tic)amide inhibits the phosphorylation of the Thr34 site of DARPP - 32. |
| Note: | "drug comb, no disease" |
| Score: | 2.0 |
| Pubmed(PMID): | 16490283 |
| Sentence Index: | 16490283_5-6 |
| Sentence: | "Similarly, PFR(Tic)amide, a 'super-agonist' of NPFF receptors, inhibited the production of cAMP and slightly decreased DARPP-32/Thr34 phosphorylation in PC-12/rNPFF1 cells. Intracerebroventricular injections of PFR(Tic)amide blocked behavioral sensitization of locomotor activity to amphetamine, and intrathecal injection of PFR(Tic)amide caused a dose-dependent antinociception in vivo in rats." |
Sequence & Structure:
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPALLFRVSEHSSPEEESSPHQRTSGEGHHPKSKRPNPCAYTPPSLKAVQRIAESHLQTISNLSENQASEEEDELGELRELGYPQEDDEEDEDEDEEEDEEEDSQAEVLKGSRGTAGQKLTSGQGLEGPWERPPPLDEPQRDGNSEDQGEGRATQSEPGEEPRHPTPPESGT
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
