| Id: | acc3081 |
| Group: | 2sens |
| Protein: | eIF2alpha |
| Gene Symbol: | Eif2a |
| Protein Id: | Q8BJW6 |
| Protein Name: | EIF2A_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser51 |
| Site Sequence: | YTFSKDGTLFAWSNGEKVNII |
| Disease Category: | Cell stress and damage |
| Disease: | Apoptosis |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | TNFα |
| Drug Info: | "TNFα, also known as tumor necrosis factor - alpha, is a cytokine involved in systemic inflammation and immune responses." |
| Effect: | modulate |
| Effect Info: | "Treatment with TNFα induces the phosphorylation of eIF2alpha and the activation of caspase 3 through the dsRNA-activated eIF2alpha kinase PKR, and phosphorylated eIF2alpha is sufficient to induce apoptosis." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 16717090 |
| Sentence Index: | 16717090_3-4 |
| Sentence: | "We used gene targeting to replace the wild-type Ser(51) allele with an Ala in the eIF2alpha gene to test the hypothesis that translational control through eIF2alpha phosphorylation is a central death stimulus in eukaryotic cells. Homozygous eIF2alpha mutant mouse embryo fibroblasts were resistant to the apoptotic effects of dsRNA, tumor necrosis factor-alpha, and serum deprivation." |
Sequence & Structure:
MAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPRESGRNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNTIANKLHLQKVNDFNLSPGTQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTIKYQAVPSEVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALKNQRKHEAKKAAKQEARSDAAPTPVPQSAPRNTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
