| Id: | acc3082 |
| Group: | 2sens |
| Protein: | eIF2alpha |
| Gene Symbol: | Eif2a |
| Protein Id: | Q8BJW6 |
| Protein Name: | EIF2A_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser51 |
| Site Sequence: | YTFSKDGTLFAWSNGEKVNII |
| Disease Category: | Cell stress and damage |
| Disease: | Apoptosis |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | TNFalpha |
| Drug Info: | TNFalpha is a drug. It is likely related to the regulation of tumor necrosis factor - alpha in the body. |
| Effect: | modulate |
| Effect Info: | "Treatment with TNFα induces the phosphorylation of eIF2alpha and the activation of caspase 3 through the dsRNA-activated eIF2alpha kinase PKR, and phosphorylated eIF2alpha is sufficient to induce apoptosis." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 16717090 |
| Sentence Index: | 16717090_2-3 |
| Sentence: | Phosphorylation of the translation initiation factor 2 (eIF2alpha)atSer(51) is a molecular signal that inhibits translation in response to activation of any of four diverse eIF2alpha stress kinases. We used gene targeting to replace the wild-type Ser(51) allele with an Ala in the eIF2alpha gene to test the hypothesis that translational control through eIF2alpha phosphorylation is a central death stimulus in eukaryotic cells. |
Sequence & Structure:
MAPSTPLLTVRGSEGLYMVNGPPHFTESTVLPRESGRNCKVYTFSKDGTLFAWSNGEKVNIINVANKGLLHSFDLPKAVCLEFSPNNTVLATWQPYTTSKDGTAGTPNLQLYDMKTGACLKSFIQKKMQNWCPSWSDDEIICARNVNNEVHFFENNNFNTIANKLHLQKVNDFNLSPGTQPYKVAVYVPGSKGAPSFVRLYQYPNFAGPQAALANKSFFKADKVTMLWNKKATAVLVIASTEVDKTGASYYGEQTLHYIATNGESAVVQLPKNGPIYDVVWNSSSTEFCAVYGFMPAKATVFNLKCDPVFDFGTGPRNAAFYSPHGHILVLAGFGNLRGQMEVWDVKNYKLISKPVASDSTYFAWCPDGEHILTATCAPRLRVNNGYKIWHYTGSLLHKYDVPSNGELWQVSWQPFLDGIFPAKTIKYQAVPSEVPSEEPKVATAYRPPALRNKPVTNSKLHEEEPPQNMKPHPGSDKPLSKTALKNQRKHEAKKAAKQEARSDAAPTPVPQSAPRNTVTQSASGDPEVDKKIKNLKKKLKAIEQLKEQAAAGKQLEKNQLEKIQKETALLQELEDLELGV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
