| Id: | acc3083 |
| Group: | 2sens |
| Protein: | IkappaBalpha |
| Gene Symbol: | CHUK |
| Protein Id: | O15111 |
| Protein Name: | IKKA_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser180 |
| Site Sequence: | DVDQGSLCTSFVGTLQYLAPE |
| Disease Category: | Cancer |
| Disease: | Leukemia |
| Disease Subtype: | |
| Disease Cellline: | KBM–5 |
| Disease Info: | |
| Drug: | TNF |
| Drug Info: | "TNF is a type of tumor necrosis factor, which can regulate immune responses and cell functions." |
| Effect: | inhibit |
| Effect Info: | Indirubin enhances apoptosis by inhibiting the activation of the NF–kappaB signaling pathway induced by tumor necrosis factor (TNF). |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 16785236 |
| Sentence Index: | 16785236_5-6 |
| Sentence: | "Further studies showed that indirubin blocked the phosphorylation and degradation of IkappaB alpha through the inhibition of activation of IkappaB alpha kinase and phosphorylation and nuclear translocation of p65. NF-kappaB reporter activity induced by TNFR1, TNF receptor-associated death domain, TRAF2, TAK1, NF-kappaB-inducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection." |
Sequence & Structure:
MERPPGLRPGAGGPWEMRERLGTGGFGNVCLYQHRELDLKIAIKSCRLELSTKNRERWCHEIQIMKKLNHANVVKACDVPEELNILIHDVPLLAMEYCSGGDLRKLLNKPENCCGLKESQILSLLSDIGSGIRYLHENKIIHRDLKPENIVLQDVGGKIIHKIIDLGYAKDVDQGSLCTSFVGTLQYLAPELFENKPYTATVDYWSFGTMVFECIAGYRPFLHHLQPFTWHEKIKKKDPKCIFACEEMSGEVRFSSHLPQPNSLCSLVVEPMENWLQLMLNWDPQQRGGPVDLTLKQPRCFVLMDHILNLKIVHILNMTSAKIISFLLPPDESLHSLQSRIERETGINTGSQELLSETGISLDPRKPASQCVLDGVRGCDSYMVYLFDKSKTVYEGPFASRSLSDCVNYIVQDSKIQLPIIQLRKVWAEAVHYVSGLKEDYSRLFQGQRAAMLSLLRYNANLTKMKNTLISASQQLKAKLEFFHKSIQLDLERYSEQMTYGISSEKMLKAWKEMEEKAIHYAEVGVIGYLEDQIMSLHAEIMELQKSPYGRRQGDLMESLEQRAIDLYKQLKHRPSDHSYSDSTEMVKIIVHTVQSQDRVLKELFGHLSKLLGCKQKIIDLLPKVEVALSNIKEADNTVMFMQGKRQKEIWHLLKIACTQSSARSLVGSSLEGAVTPQTSAWLPPTSAEHDHSLSCVVTPQDGETSAQMIEENLNCLGHLSTIIHEANEEQGNSMMNLDWSWLTE
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
