| Id: | acc3085 |
| Group: | 2sens |
| Protein: | IkappaBalpha |
| Gene Symbol: | NFKBIA |
| Protein Id: | P25963 |
| Protein Name: | IKBA_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser32 |
| Site Sequence: | ERLLDDRHDSGLDSMKDEEYE |
| Disease Category: | Cancer |
| Disease: | Leukemia |
| Disease Subtype: | |
| Disease Cellline: | KBM–5 |
| Disease Info: | |
| Drug: | TNF |
| Drug Info: | "TNF is a type of tumor necrosis factor, which can regulate immune responses and cell functions." |
| Effect: | inhibit |
| Effect Info: | Indirubin enhances apoptosis by inhibiting the activation of the NF–kappaB signaling pathway induced by tumor necrosis factor (TNF). |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 16785236 |
| Sentence Index: | 16785236_5-6 |
| Sentence: | "Further studies showed that indirubin blocked the phosphorylation and degradation of IkappaB alpha through the inhibition of activation of IkappaB alpha kinase and phosphorylation and nuclear translocation of p65. NF-kappaB reporter activity induced by TNFR1, TNF receptor-associated death domain, TRAF2, TAK1, NF-kappaB-inducing kinase, and IKKbeta was inhibited by indirubin but not that induced by p65 transfection." |
Sequence & Structure:
MFQAAERPQEWAMEGPRDGLKKERLLDDRHDSGLDSMKDEEYEQMVKELQEIRLEPQEVPRGSEPWKQQLTEDGDSFLHLAIIHEEKALTMEVIRQVKGDLAFLNFQNNLQQTPLHLAVITNQPEIAEALLGAGCDPELRDFRGNTPLHLACEQGCLASVGVLTQSCTTPHLHSILKATNYNGHTCLHLASIHGYLGIVELLVSLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEFTEDELPYDDCVFGGQRLTL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTAC| NFKBIA-Ser32 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 32 | U | Head and neck squamous cell carcinoma | Phosphorylation | 21281788 |
| T | 32 | U | Head and neck squamous cell carcinoma | Phosphorylation | 21281788 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
