| Id: | acc3133 |
| Group: | 2sens |
| Protein: | eIF2alpha |
| Gene Symbol: | Eif2s1 |
| Protein Id: | P68101 |
| Protein Name: | IF2A_RAT |
| PTM: | phosphorylation |
| Site: | Ser51 |
| Site Sequence: | IEGMILLSELSRRRIRSINKL |
| Disease Category: | Nervous system diseases |
| Disease: | Hypomyelination and Oligodendrocyte Loss |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Salubrinal |
| Drug Info: | Salubrinal is a drug that has potential in the field of biological research and may be involved in regulating certain cellular processes. |
| Effect: | modulate |
| Effect Info: | Salubrinal alleviates diseases by inhibiting the PP1 - GADD34 phosphatase complex and increasing the phosphorylation level of eIF2α. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 18818381 |
| Sentence Index: | 18818381_6-7 |
| Sentence: | "Furthermore, treatment with salubrinal, a small chemical compound that specifically inhibits protein phosphatase 1(PP1)-GADD34 phosphatase activity, increased the levels of p-eIF2alpha and ameliorated hypomyelination and oligodendrocyte loss in cultured hippocampal slices exposed to IFN-gamma. Thus, our data provide evidence that an enhanced integrated stress response could promote oligodendrocyte survival in immune-mediated demyelination diseases." |
Sequence & Structure:
MPGLSCRFYQHKFPEVEDVVMVNVRSIAEMGAYVSLLEYNNIEGMILLSELSRRRIRSINKLIRIGRNECVVVIRVDKEKGYIDLSKRRVSPEEAIKCEDKFTKSKTVYSILRHVAEVLEYTKDEQLESLFQRTAWVFDDKYKRPGYGAYDAFKHAVSDPSILDSLDLNEDEREVLINNINRRLTPQAVKIRADIEVACYGYEGIDAVKEALRAGLNCSTETMPIKINLIAPPRYVMTTTTLERTEGLSVLNQAMAVIKEKIEEKRGVFNVQMEPKVVTDTDETELARQLERLERENAEVDGDDDAEEMEAKAED
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
