| Id: | acc3139 |
| Group: | 2sens |
| Protein: | Akt |
| Gene Symbol: | MET |
| Protein Id: | Q9H8T0 |
| Protein Name: | AKTIP_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser473 |
| Site Sequence: | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Infarction |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | Glimepiride |
| Drug Info: | Glimepiride is an oral antidiabetic drug used to control high blood sugar in patients with type 2 diabetes. |
| Effect: | modulate |
| Effect Info: | Glimepiride can significantly reduce the infarct size after myocardial reperfusion injury in rabbits by activating the phosphorylation of Akt in the PI3K/Akt signaling pathway. |
| Note: | ID not sure |
| Score: | 4.0 |
| Pubmed(PMID): | 19202319 |
| Sentence Index: | 19202319_12-13 |
| Sentence: | "Akt phosphorylationation was inhibited by LY294002. In conclusion, our study demonstrates that glimepiride treatment upon reperfusion reduces infarct size in rabbit hearts via a PI3K/Akt-mediated pathway." |
Sequence & Structure:
MNPFWSMSTSSVRKRSEGEEKTLTGDVKTSPPRTAPKKQLPSIPKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDTASPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPEEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
