Id: acc3148
Group: 2sens
Protein: Cdc25C
Gene Symbol: CDC25C
Protein Id: P30307
Protein Name: MPIP3_HUMAN
PTM: phosphorylation
Site: Ser216
Site Sequence: SRSGLYRSPSMPENLNRPRLK
Disease Category: Cancer
Disease: Hepatocellular Carcinoma
Disease Subtype:
Disease Cellline: Hep3B
Disease Info:
Drug: HKH40A
Drug Info: "HKH40A is a drug with potential medical applications, although specific details about it are not provided."
Effect: modulate
Effect Info: "Inhibiting the activity of Cdc25C through Chk1/2 - mediated inhibitory phosphorylation leads to the phosphorylation of downstream Cdk1 and cell cycle G2/M arrest, thereby inducing cell apoptosis."
Note:
Score: 4.0
Pubmed(PMID): 19530246
Sentence Index:
Sentence:

Sequence & Structure:

MSTELFSSTREEGSSGSGPSFRSNQRKMLNLLLERDTSFTVCPDVPRTPVGKFLGDSANLSILSGGTPKRCLDLSNLSSGEITATQLTTSADLDETGHLDSSGLQEVHLAGMNHDQHLMKCSPAQLLCSTPNGLDRGHRKRDAMCSSSANKENDNGNLVDSEMKYLGSPITTVPKLDKNPNLGEDQAEEISDELMEFSLKDQEAKVSRSGLYRSPSMPENLNRPRLKQVEKFKDNTIPDKVKKKYFSGQGKLRKGLCLKKTVSLCDITITQMLEEDSNQGHLIGDFSKVCALPTVSGKHQDLKYVNPETVAALLSGKFQGLIEKFYVIDCRYPYEYLGGHIQGALNLYSQEELFNFFLKKPIVPLDTQKRIIIVFHCEFSSERGPRMCRCLREEDRSLNQYPALYYPELYILKGGYRDFFPEYMELCEPQSYCPMHHQDHKTELLRCRSQSKVQEGERQLREQIALLVKDMSP

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
CDC25C-Ser216
Cancer Intensity
BRCA 0.236
COAD
HGSC
ccRCC
GBM 0.481
HNSC 0.035
LUAD -0.999
LUSC -1.233
non_ccRCC
PDAC
UCEC 1.48

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 216 U Colorectal carcinoma Phosphorylation 35999268
S 216 U High-grade serous ovarian carcinoma Phosphorylation 35017636

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: