| Id: | acc3160 |
| Group: | 2sens |
| Protein: | CREB |
| Gene Symbol: | Creb1 |
| Protein Id: | Q01147 |
| Protein Name: | CREB1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser133 |
| Site Sequence: | LNDLSSDAPGVPRIEEEKSEE |
| Disease Category: | Nervous system diseases |
| Disease: | Depression |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | flavonol |
| Drug Info: | "Flavonol is a type of flavonoid, which has antioxidant and anti - inflammatory properties and may contribute to human health." |
| Effect: | modulate |
| Effect Info: | "Ginkgo flavonoids quercetin and kaempferol can stimulate the signaling pathways associated with depression, involving the phosphorylation of brain-derived neurotrophic factor (BDNF)/cAMP response element-binding protein (CREB)/postsynaptic density protein 95 (PSD95), and reduce the effects in double-transgenic Alzheimer's disease mice." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 19917299 |
| Sentence Index: | 19917299_4-5 |
| Sentence: | "We report here that ginkgo flavonols quercetin and kaempferol stimulates depression-related signaling pathways involving brain-derived neurotrophic factor BDNF/phosphorylation of cyclic AMP response element binding protein CREB/postsynaptic density proteins PSD95, and reduces amyloid-beta peptide (Abeta) in neurons isolated from double transgenic AD mouse (TgAPPswe/PS1e9). In addition, enhanced BDNF expression and reduction of Abeta oligomers was confirmed in hippocampus of the double transgenic mice administered with flavonol, which correlates with cognitive improvement behaviors in these mice." |
Sequence & Structure:
MTMESGADNQQSGDAAVTEAENQQMTVQAQPQIATLAQVSMPAAHATSSAPTVTLVQLPNGQTVQVHGVIQAAQPSVIQSPQVQTVQISTIAESEDSQESVDSVTDSQKRREILSRRPSYRKILNDLSSDAPGVPRIEEEKSEEETSAPAITTVTVPTPIYQTSSGQYIAITQGGAIQLANNGTDGVQGLQTLTMTNAAATQPGTTILQYAQTTDGQQILVPSNQVVVQAASGDVQTYQIRTAPTSTIAPGVVMASSPALPTQPAEEAARKREVRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKALKDLYCHKSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| S | 133 | D | Type 2 diabetes | Phosphorylation | 34193609 |
| S | 133 | N | Heart failure | Phosphorylation | 17616745 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
