Id: acc3167
Group: 2sens
Protein: IkappaBalpha
Gene Symbol: Nfkbia
Protein Id: Q9Z1E3
Protein Name: IKBA_MOUSE
PTM: phosphorylation
Site: Ser32
Site Sequence: ERLVDDRHDSGLDSMKDEEYE
Disease Category: Immune system diseases
Disease: Inflammation
Disease Subtype: edema
Disease Cellline:
Disease Info:
Drug: "icariin derivative (3,5-dihydroxy-4'-methoxy-6'',6''-dimethy1-4'',5''-dihydropyrano[2'',3'':7,8]-fl
Drug Info: "The drug is an icariin derivative, specifically 3,5-dihydroxy-4'-methoxy-6'',6''-dimethy1-4'',5''-dihydropyrano[2'',3'':7,8]-flavone. "
Effect: modulate
Effect Info: "The compound inhibits the activation of p38 MAPK and suppresses the translocation of NF-kappaB p65 into the nucleus by reducing the phosphorylation of IkappaBalpha, thus alleviating paw edema in mice."
Note:
Score: 4.0
Pubmed(PMID): 20686223
Sentence Index:
Sentence:

Sequence & Structure:

MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEEYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKPLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLAIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: