Id: | acc3167 |
Group: | 2sens |
Protein: | IkappaBalpha |
Gene Symbol: | Nfkbia |
Protein Id: | Q9Z1E3 |
Protein Name: | IKBA_MOUSE |
PTM: | phosphorylation |
Site: | Ser32 |
Site Sequence: | ERLVDDRHDSGLDSMKDEEYE |
Disease Category: | Immune system diseases |
Disease: | Inflammation |
Disease Subtype: | edema |
Disease Cellline: | |
Disease Info: | |
Drug: | "icariin derivative (3,5-dihydroxy-4'-methoxy-6'',6''-dimethy1-4'',5''-dihydropyrano[2'',3'':7,8]-fl |
Drug Info: | "The drug is an icariin derivative, specifically 3,5-dihydroxy-4'-methoxy-6'',6''-dimethy1-4'',5''-dihydropyrano[2'',3'':7,8]-flavone. " |
Effect: | modulate |
Effect Info: | "The compound inhibits the activation of p38 MAPK and suppresses the translocation of NF-kappaB p65 into the nucleus by reducing the phosphorylation of IkappaBalpha, thus alleviating paw edema in mice." |
Note: | |
Score: | 4.0 |
Pubmed(PMID): | 20686223 |
Sentence Index: | 20686223_3-4 |
Sentence: | "It also alleviates paw edema induced by carrageenan in mice. To clarify the molecular mechanisms underlying these anti-inflammatory effects, we examined the effects of this compound on the phosphorylation of mitogen-activated protein kinase (MAPK), phosphorylation of inhibitory kappaBalpha (IkappaBalpha), and nuclear translocation of p65 subunit of nuclear factor (NF)-kappaB, and found it suppresses the activation of p38 MAPK and inhibits translocation of NF-kappaB p65 to the nucleus through decreasing the phosphorylation of IkappaBalpha." |
Sequence & Structure:
MFQPAGHGQDWAMEGPRDGLKKERLVDDRHDSGLDSMKDEEYEQMVKELREIRLQPQEAPLAAEPWKQQLTEDGDSFLHLAIIHEEKPLTMEVIGQVKGDLAFLNFQNNLQQTPLHLAVITNQPGIAEALLKAGCDPELRDFRGNTPLHLACEQGCLASVAVLTQTCTPQHLHSVLQATNYNGHTCLHLASIHGYLAIVEHLVTLGADVNAQEPCNGRTALHLAVDLQNPDLVSLLLKCGADVNRVTYQGYSPYQLTWGRPSTRIQQQLGQLTLENLQMLPESEDEESYDTESEFTEDELPYDDCVFGGQRLTL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.