| Id: | acc3173 |
| Group: | 2sens |
| Protein: | p53 |
| Gene Symbol: | Tp53 |
| Protein Id: | P02340 |
| Protein Name: | P53_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser18 |
| Site Sequence: | SDISLELPLSQETFSGLWKLL |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Insulin Resistance |
| Disease Subtype: | p53S18A |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | N-Acetyl cysteine (NAC) |
| Drug Info: | "N-Acetyl cysteine (NAC) is a well - known antioxidant drug, often used to help break up mucus and is also involved in various biochemical processes in the body." |
| Effect: | no effect |
| Effect Info: | "p53S18A mice (with mutation to disrupt phosphorylation) develop insulin resistance, which can be treated with the antioxidant NAC." |
| Note: | |
| Score: | 2.0 |
| Pubmed(PMID): | 20956556 |
| Sentence Index: | 20956556_10-11 |
| Sentence: | The addition of an antioxidant in the diet rendered the p53 Ser18-deficient mice glucose tolerant. This analysis demonstrates that p53 phosphorylation on an ATM site is an important mechanism in the physiological regulation of glucose homeostasis. |
Sequence & Structure:
MTAMEESQSDISLELPLSQETFSGLWKLLPPEDILPSPHCMDDLLLPQDVEEFFEGPSEALRVSGAPAAQDPVTETPGPVAPAPATPWPLSSFVPSQKTYQGNYGFHLGFLQSGTAKSVMCTYSPPLNKLFCQLAKTCPVQLWVSATPPAGSRVRAMAIYKKSQHMTEVVRRCPHHERCSDGDGLAPPQHLIRVEGNLYPEYLEDRQTFRHSVVVPYEPPEAGSEYTTIHYKYMCNSSCMGGMNRRPILTIITLEDSSGNLLGRDSFEVRVCACPGRDRRTEEENFRKKEVLCPELPPGSAKRALPTCTSASPPQKKKPLDGEYFTLKIRGRKRFEMFRELNEALELKDAHATEESGDSRAHSSYLKTKKGQSTSRHKKTMVKKVGPDSD
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
