| Id: | acc3199 |
| Group: | 2sens |
| Protein: | Lyn |
| Gene Symbol: | Lyn |
| Protein Id: | P25911 |
| Protein Name: | LYN_MOUSE |
| PTM: | phosphorylation |
| Site: | unclear |
| Site Sequence: | |
| Disease Category: | Immune system diseases |
| Disease: | Allergic |
| Disease Subtype: | Delayed-Type Hypersensitivity |
| Disease Cellline: | "RBL-1,RBL-2H3" |
| Disease Info: | |
| Drug: | Valencene |
| Drug Info: | "Valencene is a natural sesquiterpene found in citrus fruits, which has potential applications in the flavor and fragrance industry." |
| Effect: | modulate |
| Effect Info: | "In rat RBL-2H3 cells, CRE and its main component Valencene → ↓ Lyn phosphorylation (initial activation of mast cells) → ↓ β-hexosaminidase degranulation; in mice, CRE and its main components valencene and nootkatone inhibited the delayed-type hypersensitivity reaction, but phosphorylation was not verified." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 21380805 |
| Sentence Index: | 21380805_5-6 |
| Sentence: | "It was also found that the most active sesquiterpene (valencene) and CRE inhibited beta-hexosaminidase degranulation by inhibiting the initial activation reaction, Lyn phosphorylation, in IgE-stimulated RBL-2H3 cells. Moreover, CRE, valencene and nootkatone significantly inhibited the delayed-type hypersensitivity reaction in mice when administered orally at 50-300 mg/kg." |
Sequence & Structure:
MGCIKSKRKDNLNDDEVDSKTQPVRNTDRTIYVRDPTSNKQQRPVPEFHLLPGQRFQTKDPEEQGDIVVALYPYDGIHPDDLSFKKGEKMKVLEEHGEWWKAKSLSSKREGFIPSNYVAKVNTLETEEWFFKDITRKDAERQLLAPGNSAGAFLIRESETLKGSFSLSVRDYDPMHGDVIKHYKIRSLDNGGYYISPRITFPCISDMIKHYQKQSDGLCRRLEKACISPKPQKPWDKDAWEIPRESIKLVKKLGAGQFGEVWMGYYNNSTKVAVKTLKPGTMSVQAFLEEANLMKTLQHDKLVRLYAVVTKEEPIYIITEFMAKGSLLDFLKSDEGGKVLLPKLIDFSAQIAEGMAYIERKNYIHRDLRAANVLVSESLMCKIADFGLARVIEDNEYTAREGAKFPIKWTAPEAINFGCFTIKSDVWSFGILLYEIVTYGKIPYPGRTNADVMSALSQGYRMPRMENCPDELYDIMKMCWKEKAEERPTFDYLQSVLDDFYTATEGQYQQQP
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
