| Id: | acc3203 |
| Group: | 2sens |
| Protein: | JNK |
| Gene Symbol: | Mapk8 |
| Protein Id: | Q91Y86 |
| Protein Name: | MK08_MOUSE |
| PTM: | phosphorylation |
| Site: | Tyr185 |
| Site Sequence: | AGTSFMMTPYVVTRYYRAPEV |
| Disease Category: | Systemic diseases |
| Disease: | Fatigue |
| Disease Subtype: | |
| Disease Cellline: | HEK 293 |
| Disease Info: | |
| Drug: | N-acetylcysteine (NAC) |
| Drug Info: | N-acetylcysteine (NAC) is a mucolytic agent that can break down mucus and is also used as an antioxidant and antidote for acetaminophen overdose. |
| Effect: | modulate |
| Effect Info: | NAC infusion blocked the exercise-induced increase in JNK phosphorylation but not that of ERK1/2 or p38 MAPK. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 21827635 |
| Sentence Index: | 21827635_5-6 |
| Sentence: | "RESULTS: Analysis was conducted on the mitogen-activated protein kinase signalling pathways, demonstrating that NAC infusion blocked the exercise-induced increase in JNK phosphorylation, but not ERK1/2, or p38 MAPK. Nuclear factor-kappaB p65 phosphorylation was unaffected by exercise; however, it was reduced in NAC at fatigue by 14% (P < 0.05) compared with pre-infusion." |
Sequence & Structure:
MSRSKRDNNFYSVEIGDSTFTVLKRYQNLKPIGSGAQGIVCAAYDAILERNVAIKKLSRPFQNQTHAKRAYRELVLMKCVNHKNIIGLLNVFTPQKSLEEFQDVYIVMELMDANLCQVIQMELDHERMSYLLYQMLCGIKHLHSAGIIHRDLKPSNIVVKSDCTLKILDFGLARTAGTSFMMTPYVVTRYYRAPEVILGMGYKENVDLWSVGCIMGEMVCHKILFPGRDYIDQWNKVIEQLGTPCPEFMKKLQPTVRTYVENRPKYAGYSFEKLFPDVLFPADSEHNKLKASQARDLLSKMLVIDASKRISVDEALQHPYINVWYDPSEAEAPPPKIPDKQLDEREHTIEEWKELIYKEVMDLEERTKNGVIRGQPSPLAQVQQ
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
