| Id: | acc3208 |
| Group: | 2sens |
| Protein: | NF-kappaB p65 |
| Gene Symbol: | Rela |
| Protein Id: | Q04207 |
| Protein Name: | TF65_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser276 |
| Site Sequence: | RVSMQLRRPSDRELSEPMEFQ |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | High Glucose |
| Disease Subtype: | |
| Disease Cellline: | 3T3L1 |
| Disease Info: | |
| Drug: | "H(2)S, L-cysteine (LC)" |
| Drug Info: | H(2)S is a chemical molecule potentially having biological effects. | L-cysteine (LC) is an amino acid with various physiological functions. |
| Effect: | modulate |
| Effect Info: | "Under hyperglycemic conditions such as diabetes, H?S or its precursor L-cysteine (LC) enhances the phosphorylation of key insulin signaling proteins such as IRS1, Akt, and PKCζ → enhances the GLUT4 pathway and improves the cellular glucose utilization ability." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 21953448 |
| Sentence Index: | 21953448_9-10 |
| Sentence: | "Comparative signal silencing studies with siAKT2 or siPKCzeta revealed that PKCzeta phosphorylation is more effective for the GLUT4 activation and glucose utilization in LC-, H(2)S-, or PIP3-treated cells exposed to HG. This is the first report to demonstrate that H(2)S or LC can increase cellular levels of PIP3, a positive regulator of glucose metabolism." |
Sequence & Structure:
MDDLFPLIFPSEPAQASGPYVEIIEQPKQRGMRFRYKCEGRSAGSIPGERSTDTTKTHPTIKINGYTGPGTVRISLVTKDPPHRPHPHELVGKDCRDGYYEADLCPDRSIHSFQNLGIQCVKKRDLEQAISQRIQTNNNPFHVPIEEQRGDYDLNAVRLCFQVTVRDPAGRPLLLTPVLSHPIFDNRAPNTAELKICRVNRNSGSCLGGDEIFLLCDKVQKEDIEVYFTGPGWEARGSFSQADVHRQVAIVFRTPPYADPSLQAPVRVSMQLRRPSDRELSEPMEFQYLPDTDDRHRIEEKRKRTYETFKSIMKKSPFNGPTEPRPPTRRIAVPTRNSTSVPKPAPQPYTFPASLSTINFDEFSPMLLPSGQISNQALALAPSSAPVLAQTMVPSSAMVPLAQPPAPAPVLTPGPPQSLSAPVPKSTQAGEGTLSEALLHLQFDADEDLGALLGNSTDPGVFTDLASVDNSEFQQLLNQGVSMSHSTAEPMLMEYPEAITRLVTGSQRPPDPAPTPLGTSGLPNGLSGDEDFSSIADMDFSALLSQISS
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
