Id: acc3217
Group: 2sens
Protein: Akt
Gene Symbol: Akt1
Protein Id: P31750
Protein Name: AKT1_MOUSE
PTM: phosphorylation
Site: Ser473
Site Sequence: ERRPHFPQFSYSASGTA----
Disease Category: Endocrine and metabolic diseases
Disease: Diabetes Mellitus
Disease Subtype: testicular oxidative damage
Disease Cellline:
Disease Info:
Drug: TPEN
Drug Info: "TPEN is a chelating agent that can bind to metal ions, which is often used in biological and chemical research."
Effect: modulate
Effect Info: "Zinc deficiency significantly enhanced the decrease in Akt and GSK - 3β phosphorylation (Fig. 1A, B) and the increase in GS phosphorylation caused by diabetes, thus exacerbating the testicular glucose metabolism changes and inflammation induced by diabetes."
Note:
Score: 4.0
Pubmed(PMID): 22000581
Sentence Index:
Sentence:

Sequence & Structure:

MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
S 473 D Alzheimer's disease Phosphorylation 35834993 36843923
S 473 D Colonic inflammation Phosphorylation 36735734
S 473 D Diabetes mellitus Phosphorylation 17130464 16777975 15033922 15033922 16777975 17130464 35739993
S 473 D Turner syndrome Phosphorylation 33910978
S 473 U Cardiomyopathy Phosphorylation 35358489
S 473 U Diabetes mellitus Phosphorylation 35358489
S 473 U Endometrial cancer/carcinoma Phosphorylation 16585156
S 473 U Melanoma Phosphorylation 26565903
S 473 U Non-small cell lung cancer Phosphorylation 35961388
S 473 U Hepatocellular carcinoma Phosphorylation 33500384

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: