| Id: | acc3221 |
| Group: | 2sens |
| Protein: | PTEN |
| Gene Symbol: | Pten |
| Protein Id: | O08586 |
| Protein Name: | PTEN_MOUSE |
| PTM: | phosphorylation |
| Site: | Thr382 |
| Site Sequence: | EPDHYRYSDTTDSDPENEPFD |
| Disease Category: | Endocrine and metabolic diseases |
| Disease: | Diabetes Mellitus |
| Disease Subtype: | testicular oxidative damage |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | TPEN |
| Drug Info: | "TPEN is a chelating agent that can bind to metal ions, which is often used in biological and chemical research." |
| Effect: | modulate |
| Effect Info: | "Zinc deficiency significantly enhanced the diabetes-induced reduction of Akt and GSK-3β phosphorylation (Fig. 1A, B) and the activation of GS and PTEN, thereby exacerbating diabetes-induced testicular glucose metabolism changes and inflammation." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22000581 |
| Sentence Index: | 22000581_4-5 |
| Sentence: | "After diabetes onset induced by streptozotocin, both diabetic and age-matched control mice were given TPEN intraperitoneally for 4 months. Western blotting assay revealed that Akt-mediated glucose metabolism signaling was down-regulated in the diabetic testis and was further decreased in diabetic mice with Zn deficiency, reflected by reduced phosphorylation of both Akt and GSK-3beta and increased phosphorylation of glycogen synthase along with a disarrangement of fatty acid metabolism (increased expression of PPAR-alpha and decreased adenosine-monophosphate-activated protein kinase phosphorylation)." |
Sequence & Structure:
MTAIIKEIVSRNKRRYQEDGFDLDLTYIYPNIIAMGFPAERLEGVYRNNIDDVVRFLDSKHKNHYKIYNLCAERHYDTAKFNCRVAQYPFEDHNPPQLELIKPFCEDLDQWLSEDDNHVAAIHCKAGKGRTGVMICAYLLHRGKFLKAQEALDFYGEVRTRDKKGVTIPSQRRYVYYYSYLLKNHLDYRPVALLFHKMMFETIPMFSGGTCNPQFVVCQLKVKIYSSNSGPTRREDKFMYFEFPQPLPVCGDIKVEFFHKQNKMLKKDKMFHFWVNTFFIPGPEETSEKVENGSLCDQEIDSICSIERADNDKEYLVLTLTKNDLDKANKDKANRYFSPNFKVKLYFTKTVEEPSNPEASSSTSVTPDVSDNEPDHYRYSDTTDSDPENEPFDEDQHSQITKV
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
