| Id: | acc3226 |
| Group: | 2sens |
| Protein: | ERK2 |
| Gene Symbol: | MAPK1 |
| Protein Id: | Q7RTV5 |
| Protein Name: | PXL2C_HUMAN |
| PTM: | Phosphorylation |
| Site: | Tyr187 |
| Site Sequence: | GTLILGPGNNIHFIHRDRNRL |
| Disease Category: | Systemic diseases |
| Disease: | Fibrotic Disorder |
| Disease Subtype: | |
| Disease Cellline: | porcine valvular interstitial cells |
| Disease Info: | |
| Drug: | Terguride |
| Drug Info: | "Terguride is a drug, which may have specific pharmacological effects and is used to treat certain medical conditions." |
| Effect: | modulate |
| Effect Info: | "Telgulid can inhibit 5-HT-induced human platelet aggregation and 5-HT-induced cell proliferation signaling pathways (ERK1/2 phosphorylation and collagen synthesis) in porcine valve interstitial cells, and has potential therapeutic value in the treatment of fibrotic diseases." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 22049464 |
| Sentence Index: | 22049464_11-12 |
| Sentence: | "In these cells, the stimulatory effect of 5-HT on [3H]proline incorporation (index of extracellular matrix collagen) was blocked by terguride. Because of the inhibition of both 5-HT(2A) and 5-HT(2B) receptors, platelet aggregation, and cellular proliferation and activity (ERK1/2 phosphorylation and collagen production) terguride may have therapeutic potential in the treatment of fibrotic disorders." |
Sequence & Structure:
MAAPAPVTRQVSGAAALVPAPSGPDSGQPLAAAVAELPVLDARGQRVPFGALFRERRAVVVFVRHFLCYICKEYVEDLAKIPRSFLQEANVTLIVIGQSSYHHIEPFCKLTGYSHEIYVDPEREIYKRLGMKRGEEIASSGQSPHIKSNLLSGSLQSLWRAVTGPLFDFQGDPAQQGGTLILGPGNNIHFIHRDRNRLDHKPINSVLQLVGVQHVNFTNRPSVIHV
No data.
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
