Id: acc3232
Group: 2sens
Protein: SRC-3
Gene Symbol: STAC
Protein Id: Q99469
Protein Name: STAC_HUMAN
PTM: phosphorylation
Site: Ser857
Site Sequence: ----------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------
Disease Category: Cancer
Disease: Lung Cancer
Disease Subtype: non-small cell lung cancer
Disease Cellline: A549
Disease Info:
Drug: ERK3 OE
Drug Info: ERK3 OE is a specific drug or a biological entity related to ERK3 over - expression. It may play a role in relevant biological research or potential therapeutic applications.
Effect: modulate
Effect Info: ERK3 promotes the invasiveness of lung cancer cells by phosphorylating SRC - 3 and regulating SRC - 3 through site - specific phosphorylation.
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 22505454
Sentence Index:
Sentence:

Sequence & Structure:

MIPPSSPREDGVDGLPKEAVGAEQPPSPASTSSQESKLQKLKRSLSFKTKSLRSKSADNFFQRTNSEDMKLQAHMVAEISPSSSPLPAPGSLTSTPARAGLHPGGKAHAFQEYIFKKPTFCDVCNHMIVGTNAKHGLRCKACKMSIHHKCTDGLAPQRCMGKLPKGFRRYYSSPLLIHEQFGCIKEVMPIACGNKVDPVYETLRFGTSLAQRTKKGSSGSGSDSPHRTSTSDLVEVPEEANGPGGGYDLRKRSNSVFTYPENGTDDFRDPAKNINHQGSLSKDPLQMNTYVALYKFVPQENEDLEMRPGDIITLLEDSNEDWWKGKIQDRIGFFPANFVQRLQQNEKIFRCVRTFIGCKEQGQITLKENQICVSSEEEQDGFIRVLSGKKKGLIPLDVLENI

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No intensity data of this site,
show all other sites!

STAC-Ser27
Cancer Intensity
BRCA
COAD
HGSC
ccRCC -0.258
GBM 1.634
HNSC
LUAD 0.173
LUSC -0.907
non_ccRCC -0.642
PDAC
UCEC
STAC-Ser56
Cancer Intensity
BRCA
COAD
HGSC
ccRCC 0.18
GBM 0.677
HNSC
LUAD 0.717
LUSC -0.258
non_ccRCC 0.579
PDAC
UCEC -1.895
STAC2-Ser112
Cancer Intensity
BRCA -1.246
COAD
HGSC
ccRCC -0.167
GBM 0.247
HNSC
LUAD
LUSC
non_ccRCC 1.165
PDAC
UCEC
STAC2-Ser174
Cancer Intensity
BRCA 1.116
COAD
HGSC -0.301
ccRCC -0.815
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
STAC2-Ser175
Cancer Intensity
BRCA 1.08
COAD
HGSC -0.894
ccRCC -0.186
GBM
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC
STAC2-Ser18
Cancer Intensity
BRCA -0.637
COAD
HGSC
ccRCC
GBM -0.516
HNSC
LUAD
LUSC
non_ccRCC 1.153
PDAC
UCEC
STAC2-Ser192
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM -0.707
HNSC
LUAD
LUSC
non_ccRCC 0.707
PDAC
UCEC
STAC2-Ser277
Cancer Intensity
BRCA -0.733
COAD
HGSC
ccRCC -1.289
GBM 0.146
HNSC
LUAD
LUSC
non_ccRCC 1.042
PDAC
UCEC 0.833
STAC2-Ser48
Cancer Intensity
BRCA -1.405
COAD
HGSC 1.504
ccRCC -0.568
GBM -0.215
HNSC 0.495
LUAD 0.092
LUSC -1.148
non_ccRCC 1.346
PDAC
UCEC -0.102
STAC2-Ser78
Cancer Intensity
BRCA -0.558
COAD
HGSC -0.876
ccRCC -0.784
GBM -0.233
HNSC 2.034
LUAD
LUSC
non_ccRCC 0.089
PDAC
UCEC 0.328
STAC2-Ser94
Cancer Intensity
BRCA 0.707
COAD
HGSC
ccRCC
GBM
HNSC
LUAD
LUSC
non_ccRCC -0.707
PDAC
UCEC
STAC2-Thr225
Cancer Intensity
BRCA
COAD
HGSC
ccRCC
GBM -0.707
HNSC
LUAD
LUSC
non_ccRCC
PDAC
UCEC 0.707

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: