| Id: | acc3265 |
| Group: | 2sens |
| Protein: | Hsp27 |
| Gene Symbol: | SAFB |
| Protein Id: | P04792 |
| Protein Name: | HSPB1_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser82 |
| Site Sequence: | YSRALSRQLSSGVSEIRHTAD |
| Disease Category: | Cancer |
| Disease: | Cervical Cancer |
| Disease Subtype: | |
| Disease Cellline: | HeLa |
| Disease Info: | |
| Drug: | TRAIL |
| Drug Info: | TRAIL is a type of protein - based drug that has been studied for its potential anti - cancer properties by inducing apoptosis in tumor cells. |
| Effect: | increase |
| Effect Info: | The small molecule compound LY303511 enhances the sensitivity of HeLa cells to TRAIL by promoting the phosphorylation of the small chaperone protein Hsp27. |
| Note: | |
| Score: | 5.0 |
| Pubmed(PMID): | 24176848 |
| Sentence Index: | 24176848_6-7 |
| Sentence: | "Furthermore, Hsp27 phosphorylation leads to the subsequent dissociation of its large oligomers and a decrease in its chaperone activity, thereby further compromising the death inhibitory activity of Hsp27. Furthermore, genetic manipulation of Hsp27 expression significantly affected the TRAIL sensitizing activity of LY303511, which corroborated the Hsp27 targeting activity of LY303511." |
Sequence & Structure:
MTERRVPFSLLRGPSWDPFRDWYPHSRLFDQAFGLPRLPEEWSQWLGGSSWPGYVRPLPPAAIESPAVAAPAYSRALSRQLSSGVSEIRHTADRWRVSLDVNHFAPDELTVKTKDGVVEITGKHEERQDEHGYISRCFTRKYTLPPGVDPTQVSSSLSPEGTLTVEAPMPKLATQSNEITIPVTFESRAQLGGPEAAKSDETAAK
Select PDB:
| Target | Drug name | MOA | Phase | Status | Disease | Source |
|---|---|---|---|---|---|---|
| HSPB1 | APATORSEN | Heat shock protein beta-1 (HSP27) mRNA antisense inhibitor | 2 | Unknown status | squamous cell lung carcinoma | ClinicalTrials |
| HSPB1 | APATORSEN | Heat shock protein beta-1 (HSP27) mRNA antisense inhibitor | 2 | Completed | pancreatic carcinoma | ClinicalTrials |
| HSPB1 | APATORSEN | Heat shock protein beta-1 (HSP27) mRNA antisense inhibitor | 2 | Completed | non-small cell lung carcinoma | ClinicalTrials |
| HSPB1 | APATORSEN | Heat shock protein beta-1 (HSP27) mRNA antisense inhibitor | 2 | Completed | prostate cancer | ClinicalTrials |
| HSPB1 | APATORSEN | Heat shock protein beta-1 (HSP27) mRNA antisense inhibitor | 2 | Terminated | prostate cancer | ClinicalTrials |
| HSPB1 | APATORSEN | Heat shock protein beta-1 (HSP27) mRNA antisense inhibitor | 1 | Completed | neoplasm | ClinicalTrials |
| HSPB1 | APATORSEN | Heat shock protein beta-1 (HSP27) mRNA antisense inhibitor | 1 | Unknown status | urinary bladder cancer | ClinicalTrials |
Note: Only show clinically investigational or approved drugs with protein targets.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| SAFB-Ser195 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.281 |
| HGSC | |
| ccRCC | |
| GBM | -0.775 |
| HNSC | 0.714 |
| LUAD | -1.003 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 1.344 |
| SAFB-Ser196 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.613 |
| HGSC | -0.257 |
| ccRCC | |
| GBM | -0.669 |
| HNSC | 1.319 |
| LUAD | -0.974 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 1.193 |
| SAFB-Ser197 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.361 |
| HGSC | -1.629 |
| ccRCC | 0.609 |
| GBM | -0.307 |
| HNSC | 1.156 |
| LUAD | -0.531 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 1.064 |
| SAFB-Ser209 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.249 |
| COAD | |
| HGSC | |
| ccRCC | -0.171 |
| GBM | -1.528 |
| HNSC | -0.231 |
| LUAD | -0.317 |
| LUSC | -0.589 |
| non_ccRCC | -0.33 |
| PDAC | 0.861 |
| UCEC | 2.055 |
| SAFB-Ser227 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.371 |
| COAD | |
| HGSC | -2.515 |
| ccRCC | 0.324 |
| GBM | -0.533 |
| HNSC | 0.417 |
| LUAD | 0.626 |
| LUSC | 0.502 |
| non_ccRCC | |
| PDAC | 0.461 |
| UCEC | 0.347 |
| SAFB-Ser234 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.746 |
| COAD | 0.239 |
| HGSC | -1.812 |
| ccRCC | 0.715 |
| GBM | -1.405 |
| HNSC | 0.597 |
| LUAD | |
| LUSC | |
| non_ccRCC | 0.058 |
| PDAC | 1.097 |
| UCEC | -0.236 |
| SAFB-Ser235 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.208 |
| HGSC | -1.104 |
| ccRCC | 0.825 |
| GBM | -0.742 |
| HNSC | 1.228 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser246 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.312 |
| HGSC | -1.119 |
| ccRCC | |
| GBM | |
| HNSC | 0.807 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser247 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.708 |
| COAD | 0.211 |
| HGSC | -1.878 |
| ccRCC | |
| GBM | |
| HNSC | 0.513 |
| LUAD | -0.16 |
| LUSC | 0.154 |
| non_ccRCC | -0.123 |
| PDAC | -0.426 |
| UCEC | |
| SAFB-Ser263 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.035 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.909 |
| HNSC | -1.427 |
| LUAD | -0.424 |
| LUSC | 0.977 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser275 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.028 |
| ccRCC | |
| GBM | 0.343 |
| HNSC | -1.371 |
| LUAD | |
| LUSC | 1 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser288 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.287 |
| COAD | 0.296 |
| HGSC | -2.785 |
| ccRCC | 0.529 |
| GBM | -0.209 |
| HNSC | 0.567 |
| LUAD | 0.237 |
| LUSC | -0.171 |
| non_ccRCC | 0.542 |
| PDAC | 0.98 |
| UCEC | 0.301 |
| SAFB-Ser321 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser322 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser325 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser344 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser350 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | 0.707 |
| UCEC | |
| SAFB-Ser373 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | -1.52 |
| ccRCC | |
| GBM | 0.323 |
| HNSC | 0.29 |
| LUAD | 0.944 |
| LUSC | -0.915 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.88 |
| SAFB-Ser375 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | -1.779 |
| ccRCC | 0.773 |
| GBM | |
| HNSC | 0.652 |
| LUAD | 0.5 |
| LUSC | -0.599 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.452 |
| SAFB-Ser383 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.003 |
| COAD | -0.988 |
| HGSC | 2.076 |
| ccRCC | 0.552 |
| GBM | -0.919 |
| HNSC | -0.201 |
| LUAD | -0.461 |
| LUSC | -0.951 |
| non_ccRCC | 0.978 |
| PDAC | 0.569 |
| UCEC | 0.348 |
| SAFB-Ser384 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.724 |
| COAD | -0.712 |
| HGSC | -1.748 |
| ccRCC | 0.782 |
| GBM | -0.59 |
| HNSC | -0.161 |
| LUAD | -0.106 |
| LUSC | -0.177 |
| non_ccRCC | 1.907 |
| PDAC | 0.965 |
| UCEC | 0.563 |
| SAFB-Ser389 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.446 |
| HGSC | 0.114 |
| ccRCC | |
| GBM | 0.191 |
| HNSC | 1.438 |
| LUAD | |
| LUSC | -1.298 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser443 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.096 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | 1.045 |
| UCEC | -0.949 |
| SAFB-Ser504 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.528 |
| GBM | -1.354 |
| HNSC | 1.234 |
| LUAD | 0.605 |
| LUSC | 0.043 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser507 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.219 |
| COAD | |
| HGSC | |
| ccRCC | -0.125 |
| GBM | -0.191 |
| HNSC | 0.428 |
| LUAD | 0.194 |
| LUSC | 0.56 |
| non_ccRCC | 1.671 |
| PDAC | 0.405 |
| UCEC | -1.724 |
| SAFB-Ser536 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.707 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | 0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser601 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.514 |
| COAD | 0.356 |
| HGSC | -2.886 |
| ccRCC | 0.768 |
| GBM | 0.113 |
| HNSC | 0.145 |
| LUAD | 0.513 |
| LUSC | 0.373 |
| non_ccRCC | -0.289 |
| PDAC | 0.41 |
| UCEC | -0.018 |
| SAFB-Ser604 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.664 |
| COAD | -0.233 |
| HGSC | 2.582 |
| ccRCC | -0.072 |
| GBM | -1.246 |
| HNSC | -0.323 |
| LUAD | 0.052 |
| LUSC | 0.097 |
| non_ccRCC | -0.337 |
| PDAC | -0.175 |
| UCEC | -1.009 |
| SAFB-Ser614 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.707 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | -0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser617 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.707 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | -0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser760 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.707 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | -0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser761 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.422 |
| HGSC | -0.012 |
| ccRCC | 0.109 |
| GBM | 1.082 |
| HNSC | 1.583 |
| LUAD | -1.699 |
| LUSC | |
| non_ccRCC | |
| PDAC | -0.462 |
| UCEC | -0.179 |
| SAFB-Ser79 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.138 |
| COAD | |
| HGSC | 2.133 |
| ccRCC | -0.484 |
| GBM | -0.927 |
| HNSC | -0.64 |
| LUAD | -0.541 |
| LUSC | -0.635 |
| non_ccRCC | -0.807 |
| PDAC | 0.31 |
| UCEC | 0.454 |
| SAFB-Ser793 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.707 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | -0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser794 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.227 |
| GBM | -0.15 |
| HNSC | 0.094 |
| LUAD | 0.178 |
| LUSC | |
| non_ccRCC | -2.09 |
| PDAC | 0.901 |
| UCEC | 0.84 |
| SAFB-Ser803 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| SAFB-Ser807 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.707 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | -0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Ser834 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.707 |
| SAFB-Ser906 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 1.122 |
| ccRCC | |
| GBM | -0.797 |
| HNSC | |
| LUAD | -0.325 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Thr200 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.184 |
| GBM | |
| HNSC | -0.188 |
| LUAD | -1.209 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 1.212 |
| SAFB-Thr224 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -1.146 |
| GBM | |
| HNSC | 0.694 |
| LUAD | 0.453 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Thr245 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.14 |
| HGSC | -1.649 |
| ccRCC | 0.888 |
| GBM | |
| HNSC | -0.065 |
| LUAD | 0.685 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Thr374 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.773 |
| HNSC | -0.881 |
| LUAD | 1.188 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.466 |
| SAFB-Thr391 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Thr439 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.442 |
| HNSC | 1.671 |
| LUAD | -0.618 |
| LUSC | 0.02 |
| non_ccRCC | -1.356 |
| PDAC | 0.876 |
| UCEC | -0.153 |
| SAFB-Thr78 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Tyr714 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.707 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| SAFB-Tyr757 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.707 |
| GBM | |
| HNSC | 0.707 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB-Tyr801 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.134 |
| GBM | |
| HNSC | |
| LUAD | 0.926 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.06 |
| SAFB2-Ser109 | |
|---|---|
| Cancer | Intensity |
| BRCA | 2.319 |
| COAD | -0.936 |
| HGSC | -0.392 |
| ccRCC | 0.343 |
| GBM | -0.192 |
| HNSC | -0.191 |
| LUAD | -0.43 |
| LUSC | -0.491 |
| non_ccRCC | |
| PDAC | 0.978 |
| UCEC | -1.008 |
| SAFB2-Ser194 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.923 |
| HGSC | 1.062 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.139 |
| SAFB2-Ser195 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.8 |
| HGSC | 2.005 |
| ccRCC | -1.023 |
| GBM | |
| HNSC | -0.218 |
| LUAD | 0.381 |
| LUSC | |
| non_ccRCC | 0.563 |
| PDAC | -0.024 |
| UCEC | -0.885 |
| SAFB2-Ser207 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.314 |
| COAD | 0.858 |
| HGSC | 0.016 |
| ccRCC | -1.227 |
| GBM | -1.13 |
| HNSC | 0.163 |
| LUAD | 0.892 |
| LUSC | 0.021 |
| non_ccRCC | |
| PDAC | 1.827 |
| UCEC | -1.105 |
| SAFB2-Ser226 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.371 |
| COAD | |
| HGSC | -2.515 |
| ccRCC | 0.324 |
| GBM | -0.533 |
| HNSC | 0.417 |
| LUAD | 0.626 |
| LUSC | 0.502 |
| non_ccRCC | |
| PDAC | 0.461 |
| UCEC | 0.347 |
| SAFB2-Ser233 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.746 |
| COAD | 0.239 |
| HGSC | -1.812 |
| ccRCC | 0.715 |
| GBM | -1.405 |
| HNSC | 0.597 |
| LUAD | |
| LUSC | |
| non_ccRCC | 0.058 |
| PDAC | 1.097 |
| UCEC | -0.236 |
| SAFB2-Ser234 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.208 |
| HGSC | -1.104 |
| ccRCC | 0.825 |
| GBM | -0.742 |
| HNSC | 1.228 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser245 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.312 |
| HGSC | -1.119 |
| ccRCC | |
| GBM | |
| HNSC | 0.807 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser246 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.708 |
| COAD | 0.211 |
| HGSC | -1.878 |
| ccRCC | |
| GBM | |
| HNSC | 0.513 |
| LUAD | -0.16 |
| LUSC | 0.154 |
| non_ccRCC | -0.123 |
| PDAC | -0.426 |
| UCEC | |
| SAFB2-Ser262 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.035 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.909 |
| HNSC | -1.427 |
| LUAD | -0.424 |
| LUSC | 0.977 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser274 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.028 |
| ccRCC | |
| GBM | 0.343 |
| HNSC | -1.371 |
| LUAD | |
| LUSC | 1 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser287 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.287 |
| COAD | 0.296 |
| HGSC | -2.785 |
| ccRCC | 0.529 |
| GBM | -0.209 |
| HNSC | 0.567 |
| LUAD | 0.237 |
| LUSC | -0.171 |
| non_ccRCC | 0.542 |
| PDAC | 0.98 |
| UCEC | 0.301 |
| SAFB2-Ser320 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser321 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser324 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser343 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser349 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | 0.707 |
| UCEC | |
| SAFB2-Ser372 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | 0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser374 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | 0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Ser444 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.096 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | 1.045 |
| UCEC | -0.949 |
| SAFB2-Ser513 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.993 |
| COAD | -0.86 |
| HGSC | 1.689 |
| ccRCC | 0.538 |
| GBM | -0.301 |
| HNSC | -1.16 |
| LUAD | -0.045 |
| LUSC | 1.757 |
| non_ccRCC | 0.326 |
| PDAC | -0.624 |
| UCEC | -0.328 |
| SAFB2-Ser563 | |
|---|---|
| Cancer | Intensity |
| BRCA | 2.013 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.585 |
| HNSC | |
| LUAD | -0.119 |
| LUSC | -0.534 |
| non_ccRCC | |
| PDAC | -0.335 |
| UCEC | -0.44 |
| SAFB2-Ser565 | |
|---|---|
| Cancer | Intensity |
| BRCA | 2.013 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.585 |
| HNSC | |
| LUAD | -0.119 |
| LUSC | -0.534 |
| non_ccRCC | |
| PDAC | -0.335 |
| UCEC | -0.44 |
| SAFB2-Ser613 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 1.154 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -0.551 |
| PDAC | |
| UCEC | -0.603 |
| SAFB2-Ser787 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.068 |
| COAD | |
| HGSC | |
| ccRCC | -0.134 |
| GBM | 0.259 |
| HNSC | -0.564 |
| LUAD | -0.297 |
| LUSC | 0.375 |
| non_ccRCC | -2.245 |
| PDAC | 0.821 |
| UCEC | 0.717 |
| SAFB2-Ser818 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.392 |
| COAD | |
| HGSC | |
| ccRCC | 0.037 |
| GBM | -0.333 |
| HNSC | -0.093 |
| LUAD | -0.011 |
| LUSC | -0.089 |
| non_ccRCC | -2.243 |
| PDAC | 0.7 |
| UCEC | 0.64 |
| SAFB2-Ser827 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| SAFB2-Ser886 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.172 |
| COAD | |
| HGSC | 1.19 |
| ccRCC | |
| GBM | -1.276 |
| HNSC | -0.722 |
| LUAD | |
| LUSC | 0.636 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Thr100 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.293 |
| GBM | |
| HNSC | -0.02 |
| LUAD | 1.063 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.336 |
| SAFB2-Thr190 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.707 |
| HNSC | 0.707 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Thr193 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Thr201 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.404 |
| HGSC | -2.237 |
| ccRCC | 0.44 |
| GBM | |
| HNSC | 0.526 |
| LUAD | |
| LUSC | |
| non_ccRCC | 0.02 |
| PDAC | 0.463 |
| UCEC | 0.383 |
| SAFB2-Thr223 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -1.146 |
| GBM | |
| HNSC | 0.694 |
| LUAD | 0.453 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Thr244 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.14 |
| HGSC | -1.649 |
| ccRCC | 0.888 |
| GBM | |
| HNSC | -0.065 |
| LUAD | 0.685 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| SAFB2-Thr440 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.442 |
| HNSC | 1.671 |
| LUAD | -0.618 |
| LUSC | 0.02 |
| non_ccRCC | -1.356 |
| PDAC | 0.876 |
| UCEC | -0.153 |
| SAFB2-Tyr825 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.134 |
| GBM | |
| HNSC | |
| LUAD | 0.926 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.06 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
