Id: | acc3285 |
Group: | 2sens |
Protein: | ERK1 |
Gene Symbol: | Mapk3 |
Protein Id: | Q63844 |
Protein Name: | MK03_MOUSE |
PTM: | phosphorylation |
Site: | Thr202 |
Site Sequence: | DPEHDHTGFLTEYVATRWYRA |
Disease Category: | Pain syndromes |
Disease: | Pain |
Disease Subtype: | |
Disease Cellline: | |
Disease Info: | |
Drug: | acupuncture |
Drug Info: | Acupuncture is not a drug. It is a form of traditional Chinese medicine where thin needles are inserted into specific points on the body to treat various health conditions. |
Effect: | promote |
Effect Info: | "In a mouse pain model, acupuncture treatment exerts an analgesic effect by inducing the phosphorylation of ERK protein." |
Note: | Non-conventional drugs |
Score: | 4.5 |
Pubmed(PMID): | 24524846 |
Sentence Index: | 24524846_5-6 |
Sentence: | "Second, in mouse pain models using formalin and complete Freund adjuvant, we found that acupuncture attenuated the nociceptive behavior and the mechanical allodynia; these effects were blocked when ERK cascade was interrupted by the mitogen-activated protein kinase kinase (MEK)/mitogen-activated protein kinase (MAPK) inhibitor U0126 (.8 mug/muL). Based on these results, we suggest that ERK phosphorylation following acupuncture needling is a biochemical hallmark initiating the effect of acupuncture including analgesia." |
Sequence & Structure:
MAAAAAAPGGGGGEPRGTAGVVPVVPGEVEVVKGQPFDVGPRYTQLQYIGEGAYGMVSSAYDHVRKTRVAIKKISPFEHQTYCQRTLREIQILLRFRHENVIGIRDILRAPTLEAMRDVYIVQDLMETDLYKLLKSQQLSNDHICYFLYQILRGLKYIHSANVLHRDLKPSNLLINTTCDLKICDFGLARIADPEHDHTGFLTEYVATRWYRAPEIMLNSKGYTKSIDIWSVGCILAEMLSNRPIFPGKHYLDQLNHILGILGSPSQEDLNCIINMKARNYLQSLPSKTKVAWAKLFPKSDSKALDLLDRMLTFNPNKRITVEEALAHPYLEQYYDPTDEPVAEEPFTFDMELDDLPKERLKELIFQETARFQPGAPEGP
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDResidue | Position | State | Disease | Class | PMID |
---|---|---|---|---|---|
T | 203 | U | Squamous cell carcinoma | Phosphorylation | 19934324 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.