Id: acc3295
Group: 2sens
Protein: ERRgamma
Gene Symbol: ESRRG
Protein Id: P62508
Protein Name: ERR3_HUMAN
PTM: phosphorylation
Site: Ser57
Site Sequence: SLTDSVNHHSPGGSSDASGSY
Disease Category: Cancer
Disease: Breast Cancer
Disease Subtype: ER+
Disease Cellline: MCF-7
Disease Info:
Drug: tamoxifen (TAM)
Drug Info: Tamoxifen (TAM) is a well - known drug often used in the treatment of breast cancer. It works by interfering with the effects of estrogen in the breast tissue.
Effect: inhibit
Effect Info: "The RK/MAPK signaling pathway promotes the tamoxifen - resistant phenotype mediated by ERRγ by phosphorylating ERRγ to enhance its protein stability and transcriptional activity. Mutating the ERK target site weakens the activity of ERRγ and tamoxifen resistance, suggesting that ERRγ phosphorylation plays a key regulatory role in the development of breast cancer resistance. "
Note:
Score: 5.0
Pubmed(PMID): 24684682
Sentence Index:
Sentence:

Sequence & Structure:

MDSVELCLPESFSLHYEEELLCRMSNKDRHIDSSCSSFIKTEPSSPASLTDSVNHHSPGGSSDASGSYSSTMNGHQNGLDSPPLYPSAPILGGSGPVRKLYDDCSSTIVEDPQTKCEYMLNSMPKRLCLVCGDIASGYHYGVASCEACKAFFKRTIQGNIEYSCPATNECEITKRRRKSCQACRFMKCLKVGMLKEGVRLDRVRGGRQKYKRRIDAENSPYLNPQLVQPAKKPYNKIVSHLLVAEPEKIYAMPDPTVPDSDIKALTTLCDLADRELVVIIGWAKHIPGFSTLSLADQMSLLQSAWMEILILGVVYRSLSFEDELVYADDYIMDEDQSKLAGLLDLNNAILQLVKKYKSMKLEKEEFVTLKAIALANSDSMHIEDVEAVQKLQDVLHEALQDYEAGQHMEDPRRAGKMLMTLPLLRQTSTKAVQHFYNIKLEGKVPMHKLFLEMLEAKV

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

Target Drug name MOA Phase Status Disease Source
ESRRG AFIMOXIFENE Estrogen-related receptor gamma antagonist 2 Completed breast ductal carcinoma in situ ClinicalTrials
ESRRG AFIMOXIFENE Estrogen-related receptor gamma antagonist 2 Recruiting breast ductal carcinoma in situ ClinicalTrials
ClinicalTrials
ESRRG AFIMOXIFENE Estrogen-related receptor gamma antagonist 2 Completed mastodynia ClinicalTrials
ESRRG AFIMOXIFENE Estrogen-related receptor gamma antagonist 2 Completed breast cancer ClinicalTrials

Note: Only show clinically investigational or approved drugs with protein targets.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: