| Id: | acc3300 |
| Group: | 2sens |
| Protein: | S6K1 |
| Gene Symbol: | Rps6kb1 |
| Protein Id: | P67999 |
| Protein Name: | KS6B1_RAT |
| PTM: | phosphorylation |
| Site: | Thr389 |
| Site Sequence: | SQFDSKFTRQTPVDSPDDSTL |
| Disease Category: | Nervous system diseases |
| Disease: | Parkinson's Disease |
| Disease Subtype: | neuronal cell death |
| Disease Cellline: | PC12 |
| Disease Info: | |
| Drug: | "6-hydroxydopamine,N-methyl-4-phenylpyridine,rotenone" |
| Drug Info: | "The <|Drug|> includes 6 - hydroxydopamine, N - methyl - 4 - phenylpyridine and rotenone, which are likely to have relevance in certain pharmacological or biological research." |
| Effect: | modulate |
| Effect Info: | "In PC12 cells and primary neurons, PD-related toxins (6-OHDA, MPP+, rotenone) inhibit the phosphorylation of mTOR, S6K1, and 4E-BP1, leading to decreased cell viability and activation of apoptotic proteins, which triggers neuronal cell death." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 24726895 |
| Sentence Index: | 24726895_4-5 |
| Sentence: | "Here, we show that PD mimetics (6-hydroxydopamine, N-methyl-4-phenylpyridine or rotenone) suppressed phosphorylation of mTOR, S6K1 and 4E-BP1, reduced cell viability, and activated caspase-3 and PARP in PC12 cells and primary neurons. Overexpression of wild-type mTOR or constitutively active S6K1, or downregulation of 4E-BP1 in PC12 cells partially prevented cell death in response to the PD toxins, revealing that mTOR-mediated S6K1 and 4E-BP1 pathways due to the PD toxins were inhibited, leading to neuronal cell death." |
Sequence & Structure:
MRRRRRRDGFYPAPDFRHREAEDMAGVFDIDLDQPEDAGSEDELEEGGQLNESMDHGGVGPYELGMEHCEKFEISETSVNRGPEKIRPECFELLRVLGKGGYGKVFQVRKVTGANTGKIFAMKVLKKAMIVRNAKDTAHTKAERNILEEVKHPFIVDLIYAFQTGGKLYLILEYLSGGELFMQLEREGIFMEDTACFYLAEISMALGHLHQKGIIYRDLKPENIMLNHQGHVKLTDFGLCKESIHDGTVTHTFCGTIEYMAPEILMRSGHNRAVDWWSLGALMYDMLTGAPPFTGENRKKTIDKILKCKLNLPPYLTQEARDLLKKLLKRNAASRLGAGPGDAGEVQAHPFFRHINWEELLARKVEPPFKPLLQSEEDVSQFDSKFTRQTPVDSPDDSTLSESANQVFLGFTYVAPSVLESVKEKFSFEPKIRSPRRFIGSPRTPVSPVKFSPGDFWGRGASASTANPQTPVEYPMETSGIEQMDVTTSGEASAPLPIRQPNSGPYKKQAFPMISKRPEHLRMNL
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
