Id: acc3301
Group: 2sens
Protein: cortactin
Gene Symbol: CTTN
Protein Id: Q14247
Protein Name: SRC8_HUMAN
PTM: phosphorylation
Site: Tyr421
Site Sequence: EERLPSSPVYEDAASFKAELS
Disease Category: Cancer
Disease: Hepatocellular Carcinoma
Disease Subtype:
Disease Cellline: HUH-7
Disease Info:
Drug: "focal amplicon, 1q24.1-24.3"
Drug Info: The drug is a focal amplicon located at 1q24.1 - 24.3. It might play a role in relevant biological processes.
Effect: modulate
Effect Info: "Phosphorylation of Src kinase at the Tyr426 site can be upregulated by MPZL1 through the SHP-2 recruitment mechanism, which further promotes the phosphorylation of downstream cortactin and enhances the migratory ability of HCC cells. In addition, phosphorylation at the Tyr416 site also enhances the kinase activity of Src."
Note: Non-conventional drugs
Score: 3.0
Pubmed(PMID): 24812600
Sentence Index:
Sentence:

Sequence & Structure:

MWKASAGHAVSIAQDDAGADDWETDPDFVNDVSEKEQRWGAKTVQGSGHQEHINIHKLRENVFQEHQTLKEKELETGPKASHGYGGKFGVEQDRMDKSAVGHEYQSKLSKHCSQVDSVRGFGGKFGVQMDRVDQSAVGFEYQGKTEKHASQKDYSSGFGGKYGVQADRVDKSAVGFDYQGKTEKHESQRDYSKGFGGKYGIDKDKVDKSAVGFEYQGKTEKHESQKDYVKGFGGKFGVQTDRQDKCALGWDHQEKLQLHESQKDYKTGFGGKFGVQSERQDSAAVGFDYKEKLAKHESQQDYSKGFGGKYGVQKDRMDKNASTFEDVTQVSSAYQKTVPVEAVTSKTSNIRANFENLAKEKEQEDRRKAEAERAQRMAKERQEQEEARRKLEEQARAKTQTPPVSPAPQPTEERLPSSPVYEDAASFKAELSYRGPVSGTEPEPVYSMEAADYREASSQQGLAYATEAVYESAEAPGHYPAEDSTYDEYENDLGITAVALYDYQAAGDDEISFDPDDIITNIEMIDDGWWRGVCKGRYGLFPANYVELRQ

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
CTTN-Tyr421
Cancer Intensity
BRCA 1.206
COAD 0.607
HGSC -1.915
ccRCC 0.099
GBM 0.227
HNSC -1.143
LUAD 0.472
LUSC
non_ccRCC
PDAC 0.864
UCEC -0.416

PTM-Disease Association:

source: PTMD

No data.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: