| Id: | acc3302 |
| Group: | 2sens |
| Protein: | Src |
| Gene Symbol: | SRC |
| Protein Id: | P12931 |
| Protein Name: | SRC_HUMAN |
| PTM: | phosphorylation |
| Site: | Tyr426 |
| Site Sequence: | NEYTARQGAKFPIKWTAPEAA |
| Disease Category: | Cancer |
| Disease: | Hepatocellular Carcinoma |
| Disease Subtype: | |
| Disease Cellline: | HepG2、Hep3B、HUH-7、SMMC-7721、SK-HEP-1、Li-7 |
| Disease Info: | |
| Drug: | "focal amplicon, 1q24.1-24.2" |
| Drug Info: | "The drug is a focal amplicon located at 1q24.1 - 24.2, which may have specific implications in genetic or medical research. " |
| Effect: | modulate |
| Effect Info: | "Phosphorylation of Src kinase at the Tyr426 site can be upregulated by MPZL1 through the SHP-2 recruitment mechanism, which further promotes the phosphorylation of downstream cortactin and enhances the migratory ability of HCC cells. In addition, phosphorylation at the Tyr416 site also enhances the kinase activity of Src." |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 24812600 |
| Sentence Index: | 24812600_6-7 |
| Sentence: | "They also found that MPZL1 may recruit the SHP-2 and subsequently activate/phosphorylate Src kinase at Tyr426, promoting phosphorylation of cortactin and migration of HCC cells. It is noted that phosphorylation of Tyr416 in the activation loop of the kinase domain up-regulates enzyme activity of Src." |
Sequence & Structure:
MGSNKSKPKDASQRRRSLEPAENVHGAGGGAFPASQTPSKPASADGHRGPSAAFAPAAAEPKLFGGFNSSDTVTSPQRAGPLAGGVTTFVALYDYESRTETDLSFKKGERLQIVNNTEGDWWLAHSLSTGQTGYIPSNYVAPSDSIQAEEWYFGKITRRESERLLLNAENPRGTFLVRESETTKGAYCLSVSDFDNAKGLNVKHYKIRKLDSGGFYITSRTQFNSLQQLVAYYSKHADGLCHRLTTVCPTSKPQTQGLAKDAWEIPRESLRLEVKLGQGCFGEVWMGTWNGTTRVAIKTLKPGTMSPEAFLQEAQVMKKLRHEKLVQLYAVVSEEPIYIVTEYMSKGSLLDFLKGETGKYLRLPQLVDMAAQIASGMAYVERMNYVHRDLRAANILVGENLVCKVADFGLARLIEDNEYTARQGAKFPIKWTAPEAALYGRFTIKSDVWSFGILLTELTTKGRVPYPGMVNREVLDQVERGYRMPCPPECPESLHDLMCQCWRKEPEERPTFEYLQAFLEDYFTSTEPQYQPGENL
Select PDB:
| Target | Drug name | MOA | Phase | Status | Disease | Source |
|---|---|---|---|---|---|---|
| SRC | DASATINIB | SRC inhibitor | 4 | - | acute lymphoblastic leukemia | DailyMed DailyMed |
| SRC | DASATINIB | SRC inhibitor | 4 | Unknown status | acute lymphoblastic leukemia | ClinicalTrials |
| SRC | DASATINIB | SRC inhibitor | 4 | - | chronic myelogenous leukemia | DailyMed DailyMed |
| SRC | DASATINIB | SRC inhibitor | 4 | Completed | chronic myelogenous leukemia | ClinicalTrials ClinicalTrials |
| SRC | DASATINIB | SRC inhibitor | 4 | Unknown status | chronic myelogenous leukemia | ClinicalTrials |
| SRC | DASATINIB | SRC inhibitor | 4 | Recruiting | chronic myelogenous leukemia | ClinicalTrials ClinicalTrials ClinicalTrials |
| SRC | VANDETANIB | Tyrosine-protein kinase SRC inhibitor | 4 | - | neoplasm | ATC |
| SRC | DASATINIB | SRC inhibitor | 4 | - | neoplasm | ATC |
| SRC | TIRBANIBULIN | Tyrosine-protein kinase SRC inhibitor | 4 | Completed | actinic keratosis | ClinicalTrials ClinicalTrials |
| SRC | TIRBANIBULIN | Tyrosine-protein kinase SRC inhibitor | 4 | Recruiting | actinic keratosis | ClinicalTrials |
| SRC | TIRBANIBULIN | Tyrosine-protein kinase SRC inhibitor | 4 | - | actinic keratosis | FDA DailyMed EMA |
| SRC | TIRBANIBULIN | Tyrosine-protein kinase SRC inhibitor | 4 | Withdrawn | actinic keratosis | ClinicalTrials |
| SRC | VANDETANIB | Tyrosine-protein kinase SRC inhibitor | 4 | - | thyroid carcinoma | DailyMed |
| SRC | VANDETANIB | Tyrosine-protein kinase SRC inhibitor | 4 | - | thyroid neoplasm | EMA |
| SRC | DASATINIB | SRC inhibitor | 4 | - | lymphoid leukemia | EMA |
| SRC | DASATINIB | SRC inhibitor | 4 | - | Blast Phase Chronic Myelogenous Leukemia, BCR-ABL1 Positive | EMA |
| SRC | VANDETANIB | Tyrosine-protein kinase SRC inhibitor | 4 | Active, not recruiting | thyroid cancer | ClinicalTrials |
| SRC | VANDETANIB | Tyrosine-protein kinase SRC inhibitor | 4 | - | medullary thyroid gland carcinoma | DailyMed |
| SRC | DASATINIB | SRC inhibitor | 3 | Active, not recruiting | acute lymphoblastic leukemia | ClinicalTrials |
| SRC | DASATINIB | SRC inhibitor | 3 | Not yet recruiting | acute lymphoblastic leukemia | ClinicalTrials |
| SRC | DASATINIB | SRC inhibitor | 3 | Completed | acute lymphoblastic leukemia | ClinicalTrials ClinicalTrials |
| SRC | DASATINIB | SRC inhibitor | 3 | Completed | acute myeloid leukemia | ClinicalTrials |
| SRC | BOSUTINIB | Tyrosine-protein kinase SRC inhibitor | 3 | Active, not recruiting | chronic myelogenous leukemia | ClinicalTrials ClinicalTrials |
| SRC | BOSUTINIB | Tyrosine-protein kinase SRC inhibitor | 3 | Completed | chronic myelogenous leukemia | ClinicalTrials ClinicalTrials |
| SRC | BOSUTINIB | Tyrosine-protein kinase SRC inhibitor | 3 | Not yet recruiting | chronic myelogenous leukemia | ClinicalTrials |
Note: Only show clinically investigational or approved drugs with protein targets.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| PSRC1-Ser122 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.185 | ||||
| COAD | |||||
| HGSC | 2.064 | ||||
| ccRCC | 0.294 | ||||
| GBM | -0.099 | ||||
| HNSC | -0.218 | ||||
| LUAD | -0.355 | ||||
| LUSC | -0.937 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.435 | ||||
| PSRC1-Ser175 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.059 | ||||
| COAD | |||||
| HGSC | 1.505 | ||||
| ccRCC | |||||
| GBM | 0.071 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | -1.295 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.221 | ||||
| PSRC1-Ser186 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.993 | ||||
| HNSC | |||||
| LUAD | 1.007 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.014 | ||||
| PSRC1-Ser65 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.225 | ||||
| GBM | -1.667 | ||||
| HNSC | |||||
| LUAD | -0.014 | ||||
| LUSC | 0.495 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.961 | ||||
| PSRC1-Ser70 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -1.984 | ||||
| ccRCC | 0.948 | ||||
| GBM | 0.213 | ||||
| HNSC | 0.641 | ||||
| LUAD | 0.328 | ||||
| LUSC | -0.616 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.469 | ||||
| PSRC1-Ser98 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.707 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RSRC1-Ser167 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | -0.707 | ||||
| non_ccRCC | |||||
| PDAC | 0.707 | ||||
| UCEC | |||||
| RSRC1-Ser179 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.707 | ||||
| COAD | |||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RSRC1-Ser48 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 0.389 | ||||
| HNSC | -0.318 | ||||
| LUAD | 1.351 | ||||
| LUSC | -1.201 | ||||
| non_ccRCC | -1.068 | ||||
| PDAC | -0.277 | ||||
| UCEC | 1.123 | ||||
| RSRC1-Ser5 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | -0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RSRC1-Ser50 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 0.389 | ||||
| HNSC | -0.318 | ||||
| LUAD | 1.351 | ||||
| LUSC | -1.201 | ||||
| non_ccRCC | -1.068 | ||||
| PDAC | -0.277 | ||||
| UCEC | 1.123 | ||||
| RSRC1-Ser52 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 0.389 | ||||
| HNSC | -0.318 | ||||
| LUAD | 1.351 | ||||
| LUSC | -1.201 | ||||
| non_ccRCC | -1.068 | ||||
| PDAC | -0.277 | ||||
| UCEC | 1.123 | ||||
| RSRC1-Ser6 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -1.922 | ||||
| ccRCC | |||||
| GBM | 0.423 | ||||
| HNSC | 0.95 | ||||
| LUAD | 0.44 | ||||
| LUSC | -0.056 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.164 | ||||
| RSRC1-Ser61 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 1.031 | ||||
| HNSC | -0.066 | ||||
| LUAD | -0.965 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RSRC1-Tyr62 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | -0.011 | ||||
| LUAD | -0.788 | ||||
| LUSC | -0.616 | ||||
| non_ccRCC | 1.414 | ||||
| PDAC | |||||
| UCEC | |||||
| RSRC2-Ser104 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.638 | ||||
| COAD | -1.263 | ||||
| HGSC | 2.405 | ||||
| ccRCC | 0.145 | ||||
| GBM | -0.256 | ||||
| HNSC | -0.477 | ||||
| LUAD | -0.416 | ||||
| LUSC | -0.337 | ||||
| non_ccRCC | 1.235 | ||||
| PDAC | -0.276 | ||||
| UCEC | -0.121 | ||||
| RSRC2-Ser105 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.216 | ||||
| COAD | -0.74 | ||||
| HGSC | 2.38 | ||||
| ccRCC | 0.209 | ||||
| GBM | -0.231 | ||||
| HNSC | -0.278 | ||||
| LUAD | -0.448 | ||||
| LUSC | -0.273 | ||||
| non_ccRCC | 1.276 | ||||
| PDAC | -0.31 | ||||
| UCEC | -0.368 | ||||
| RSRC2-Ser17 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RSRC2-Ser222 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.84 | ||||
| COAD | -0.875 | ||||
| HGSC | 0.375 | ||||
| ccRCC | 0.393 | ||||
| GBM | 2.166 | ||||
| HNSC | 1.022 | ||||
| LUAD | -0.274 | ||||
| LUSC | -1.511 | ||||
| non_ccRCC | -0.354 | ||||
| PDAC | 0.022 | ||||
| UCEC | -0.124 | ||||
| RSRC2-Ser27 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.519 | ||||
| COAD | 0.108 | ||||
| HGSC | -2.225 | ||||
| ccRCC | 0.356 | ||||
| GBM | |||||
| HNSC | 0.143 | ||||
| LUAD | 0.464 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.636 | ||||
| RSRC2-Ser30 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.223 | ||||
| HGSC | -2.235 | ||||
| ccRCC | 0.43 | ||||
| GBM | 0.713 | ||||
| HNSC | 0.289 | ||||
| LUAD | 0.359 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.221 | ||||
| RSRC2-Ser32 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.022 | ||||
| HGSC | -2.355 | ||||
| ccRCC | |||||
| GBM | 0.475 | ||||
| HNSC | |||||
| LUAD | 0.809 | ||||
| LUSC | 0.414 | ||||
| non_ccRCC | 0.563 | ||||
| PDAC | 0.257 | ||||
| UCEC | -0.141 | ||||
| RSRC2-Ser348 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.762 | ||||
| GBM | 0.061 | ||||
| HNSC | |||||
| LUAD | 0.607 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -1.431 | ||||
| RSRC2-Ser350 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.091 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 1.094 | ||||
| GBM | -1.363 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | 0.237 | ||||
| non_ccRCC | |||||
| PDAC | 0.746 | ||||
| UCEC | 0.378 | ||||
| RSRC2-Ser376 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.218 | ||||
| COAD | |||||
| HGSC | 0.4 | ||||
| ccRCC | 0.357 | ||||
| GBM | -1.111 | ||||
| HNSC | 1.08 | ||||
| LUAD | -2.133 | ||||
| LUSC | 0.533 | ||||
| non_ccRCC | |||||
| PDAC | 0.001 | ||||
| UCEC | 0.656 | ||||
| RSRC2-Ser383 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RSRC2-Ser384 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.81 | ||||
| HGSC | -1.118 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | 0.308 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| RSRC2-Ser41 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.707 | ||||
| RSRC2-Ser43 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.707 | ||||
| RSRC2-Thr16 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.203 | ||||
| HGSC | 1.134 | ||||
| ccRCC | 0.322 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -1.253 | ||||
| RSRC2-Thr220 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.748 | ||||
| HGSC | 0.14 | ||||
| ccRCC | -0.177 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | 1.634 | ||||
| LUSC | -0.848 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRC-Ser104 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -0.451 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | -1.396 | ||||
| LUAD | 1.411 | ||||
| LUSC | 0.602 | ||||
| non_ccRCC | -0.574 | ||||
| PDAC | 0.408 | ||||
| UCEC | |||||
| SRC-Ser17 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.429 | ||||
| COAD | -0.769 | ||||
| HGSC | 0.743 | ||||
| ccRCC | |||||
| GBM | -0.22 | ||||
| HNSC | -0.371 | ||||
| LUAD | -0.317 | ||||
| LUSC | 1.789 | ||||
| non_ccRCC | |||||
| PDAC | 0.573 | ||||
| UCEC | |||||
| SRC-Ser348 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 0.292 | ||||
| HNSC | -0.681 | ||||
| LUAD | 1.035 | ||||
| LUSC | -0.727 | ||||
| non_ccRCC | 1.622 | ||||
| PDAC | -0.901 | ||||
| UCEC | -0.639 | ||||
| SRC-Ser69 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.833 | ||||
| HGSC | 0.458 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | 0.149 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -1.44 | ||||
| SRC-Ser70 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 1.337 | ||||
| HGSC | -0.837 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | -0.69 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.19 | ||||
| SRC-Ser75 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 1.583 | ||||
| HGSC | 0.94 | ||||
| ccRCC | |||||
| GBM | 0.247 | ||||
| HNSC | -0.981 | ||||
| LUAD | 0.836 | ||||
| LUSC | -0.18 | ||||
| non_ccRCC | -1.429 | ||||
| PDAC | -0.893 | ||||
| UCEC | -0.124 | ||||
| SRC-Thr74 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.707 | ||||
| HGSC | -0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRC-Tyr419 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.413 | ||||
| HGSC | 1.82 | ||||
| ccRCC | -0.985 | ||||
| GBM | |||||
| HNSC | -0.869 | ||||
| LUAD | |||||
| LUSC | 0.833 | ||||
| non_ccRCC | |||||
| PDAC | -0.088 | ||||
| UCEC | -0.297 | ||||
| SRC-Tyr439 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 1.434 | ||||
| GBM | 0.42 | ||||
| HNSC | -0.616 | ||||
| LUAD | |||||
| LUSC | -0.062 | ||||
| non_ccRCC | -1.177 | ||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser1859 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.284 | ||||
| COAD | -0.454 | ||||
| HGSC | 2.917 | ||||
| ccRCC | -0.276 | ||||
| GBM | 0.199 | ||||
| HNSC | -0.023 | ||||
| LUAD | -0.683 | ||||
| LUSC | -0.195 | ||||
| non_ccRCC | -0.598 | ||||
| PDAC | -0.158 | ||||
| UCEC | -0.446 | ||||
| SRCAP-Ser1862 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.624 | ||||
| HGSC | 2.093 | ||||
| ccRCC | 0.034 | ||||
| GBM | 0.067 | ||||
| HNSC | -0.009 | ||||
| LUAD | -0.733 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.828 | ||||
| SRCAP-Ser1882 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.303 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.039 | ||||
| GBM | -0.984 | ||||
| HNSC | -0.17 | ||||
| LUAD | -1.238 | ||||
| LUSC | 0.419 | ||||
| non_ccRCC | 2.277 | ||||
| PDAC | 0.103 | ||||
| UCEC | -0.067 | ||||
| SRCAP-Ser2430 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.018 | ||||
| COAD | -0.582 | ||||
| HGSC | 2.616 | ||||
| ccRCC | 0.155 | ||||
| GBM | -0.095 | ||||
| HNSC | -0.271 | ||||
| LUAD | -1.061 | ||||
| LUSC | -0.372 | ||||
| non_ccRCC | -0.325 | ||||
| PDAC | 0.794 | ||||
| UCEC | -0.841 | ||||
| SRCAP-Ser250 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.686 | ||||
| COAD | 1.003 | ||||
| HGSC | -1.066 | ||||
| ccRCC | -0.622 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser257 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.449 | ||||
| GBM | |||||
| HNSC | 1.198 | ||||
| LUAD | -0.76 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.887 | ||||
| SRCAP-Ser258 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 1.447 | ||||
| HGSC | -0.939 | ||||
| ccRCC | |||||
| GBM | 0.45 | ||||
| HNSC | |||||
| LUAD | -0.898 | ||||
| LUSC | -1.409 | ||||
| non_ccRCC | 0.492 | ||||
| PDAC | -0.032 | ||||
| UCEC | 0.888 | ||||
| SRCAP-Ser270 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.579 | ||||
| GBM | |||||
| HNSC | 1.155 | ||||
| LUAD | -0.576 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser2725 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.354 | ||||
| COAD | -0.183 | ||||
| HGSC | -1.655 | ||||
| ccRCC | 1.133 | ||||
| GBM | 0.43 | ||||
| HNSC | 0.533 | ||||
| LUAD | |||||
| LUSC | 0.408 | ||||
| non_ccRCC | |||||
| PDAC | 0.689 | ||||
| UCEC | |||||
| SRCAP-Ser273 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.184 | ||||
| HGSC | -0.173 | ||||
| ccRCC | |||||
| GBM | -1.335 | ||||
| HNSC | |||||
| LUAD | 0.079 | ||||
| LUSC | 1.712 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.467 | ||||
| SRCAP-Ser274 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.183 | ||||
| HGSC | -0.483 | ||||
| ccRCC | |||||
| GBM | -0.227 | ||||
| HNSC | 2.33 | ||||
| LUAD | -0.412 | ||||
| LUSC | -0.43 | ||||
| non_ccRCC | |||||
| PDAC | -0.948 | ||||
| UCEC | -0.013 | ||||
| SRCAP-Ser2782 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.145 | ||||
| GBM | |||||
| HNSC | 1.065 | ||||
| LUAD | -0.919 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser2785 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | -0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | 0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser2787 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.576 | ||||
| COAD | 0.487 | ||||
| HGSC | -2.456 | ||||
| ccRCC | 0.33 | ||||
| GBM | 0.487 | ||||
| HNSC | -0.4 | ||||
| LUAD | |||||
| LUSC | 0.864 | ||||
| non_ccRCC | -0.211 | ||||
| PDAC | 0.824 | ||||
| UCEC | 0.651 | ||||
| SRCAP-Ser2790 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.613 | ||||
| COAD | 0.679 | ||||
| HGSC | -2.293 | ||||
| ccRCC | 0.629 | ||||
| GBM | 0.613 | ||||
| HNSC | -0.056 | ||||
| LUAD | 0.928 | ||||
| LUSC | |||||
| non_ccRCC | -0.307 | ||||
| PDAC | |||||
| UCEC | 0.419 | ||||
| SRCAP-Ser2840 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | -0.707 | ||||
| ccRCC | 0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser2869 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.035 | ||||
| COAD | -0.821 | ||||
| HGSC | -0.085 | ||||
| ccRCC | -0.089 | ||||
| GBM | -0.185 | ||||
| HNSC | -0.302 | ||||
| LUAD | -0.568 | ||||
| LUSC | -0.556 | ||||
| non_ccRCC | 2.912 | ||||
| PDAC | -0.275 | ||||
| UCEC | 0.004 | ||||
| SRCAP-Ser3016 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.171 | ||||
| COAD | -0.957 | ||||
| HGSC | 2.079 | ||||
| ccRCC | -0.097 | ||||
| GBM | -0.078 | ||||
| HNSC | -0.141 | ||||
| LUAD | -0.569 | ||||
| LUSC | -0.535 | ||||
| non_ccRCC | 1.648 | ||||
| PDAC | -0.008 | ||||
| UCEC | -0.171 | ||||
| SRCAP-Ser3020 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.324 | ||||
| COAD | -0.869 | ||||
| HGSC | 2.211 | ||||
| ccRCC | -0.69 | ||||
| GBM | 0.059 | ||||
| HNSC | -0.13 | ||||
| LUAD | -0.035 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.869 | ||||
| SRCAP-Ser3053 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | 0.707 | ||||
| LUSC | -0.707 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser3054 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | 0.707 | ||||
| LUSC | -0.707 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser3055 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | 0.707 | ||||
| LUSC | -0.707 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser3126 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.409 | ||||
| COAD | |||||
| HGSC | 2.002 | ||||
| ccRCC | -1.204 | ||||
| GBM | 0.585 | ||||
| HNSC | 0.479 | ||||
| LUAD | -0.398 | ||||
| LUSC | 0.056 | ||||
| non_ccRCC | -1.59 | ||||
| PDAC | -0.006 | ||||
| UCEC | -0.333 | ||||
| SRCAP-Ser3148 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.203 | ||||
| COAD | -0.091 | ||||
| HGSC | -1.464 | ||||
| ccRCC | -0.158 | ||||
| GBM | 0.158 | ||||
| HNSC | -0.184 | ||||
| LUAD | -0.003 | ||||
| LUSC | -0.716 | ||||
| non_ccRCC | 2.644 | ||||
| PDAC | 0.341 | ||||
| UCEC | -0.325 | ||||
| SRCAP-Ser3161 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.39 | ||||
| HGSC | -1.96 | ||||
| ccRCC | |||||
| GBM | -0.09 | ||||
| HNSC | 0.52 | ||||
| LUAD | 0.375 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.765 | ||||
| SRCAP-Ser3168 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | -0.514 | ||||
| LUAD | -0.638 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 1.152 | ||||
| SRCAP-Ser3172 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.281 | ||||
| HGSC | -1.761 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | 0.61 | ||||
| LUAD | 0.251 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 0.619 | ||||
| SRCAP-Ser3177 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.105 | ||||
| HGSC | -2.087 | ||||
| ccRCC | |||||
| GBM | 0.11 | ||||
| HNSC | 0.291 | ||||
| LUAD | |||||
| LUSC | 1.205 | ||||
| non_ccRCC | 0.106 | ||||
| PDAC | |||||
| UCEC | 0.269 | ||||
| SRCAP-Ser349 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | -0.707 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Ser562 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.171 | ||||
| COAD | -0.683 | ||||
| HGSC | |||||
| ccRCC | -0.323 | ||||
| GBM | -0.248 | ||||
| HNSC | -0.005 | ||||
| LUAD | -1.051 | ||||
| LUSC | -0.375 | ||||
| non_ccRCC | 2.304 | ||||
| PDAC | -0.143 | ||||
| UCEC | -0.648 | ||||
| SRCAP-Ser568 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.073 | ||||
| COAD | -0.215 | ||||
| HGSC | -2.158 | ||||
| ccRCC | -0.035 | ||||
| GBM | 0.084 | ||||
| HNSC | 0.201 | ||||
| LUAD | -0.575 | ||||
| LUSC | -0.074 | ||||
| non_ccRCC | 1.912 | ||||
| PDAC | 0.098 | ||||
| UCEC | -0.311 | ||||
| SRCAP-Thr1863 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.839 | ||||
| GBM | 1.106 | ||||
| HNSC | -0.267 | ||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Thr256 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | 0.707 | ||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Thr2724 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.438 | ||||
| COAD | -0.672 | ||||
| HGSC | 1.591 | ||||
| ccRCC | 0.808 | ||||
| GBM | 0.08 | ||||
| HNSC | 0.149 | ||||
| LUAD | -0.518 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCAP-Thr572 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.256 | ||||
| COAD | -0.039 | ||||
| HGSC | -2.8 | ||||
| ccRCC | 0.318 | ||||
| GBM | 0.552 | ||||
| HNSC | 0.531 | ||||
| LUAD | -0.141 | ||||
| LUSC | -0.147 | ||||
| non_ccRCC | 1.106 | ||||
| PDAC | 0.374 | ||||
| UCEC | -0.009 | ||||
| SRCAP-Tyr1885 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | -0.535 | ||||
| GBM | 1.499 | ||||
| HNSC | -0.455 | ||||
| LUAD | -0.51 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser1003 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.083 | ||||
| COAD | -0.381 | ||||
| HGSC | -0.845 | ||||
| ccRCC | 0.284 | ||||
| GBM | -0.642 | ||||
| HNSC | |||||
| LUAD | -0.549 | ||||
| LUSC | 0.093 | ||||
| non_ccRCC | 2.393 | ||||
| PDAC | 0.657 | ||||
| UCEC | 0.072 | ||||
| SRCIN1-Ser1043 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.899 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.83 | ||||
| HNSC | |||||
| LUAD | 0.806 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | 0.923 | ||||
| UCEC | |||||
| SRCIN1-Ser1060 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.188 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.448 | ||||
| HNSC | |||||
| LUAD | 0.657 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | 0.978 | ||||
| UCEC | |||||
| SRCIN1-Ser1118 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.127 | ||||
| HNSC | |||||
| LUAD | 1.057 | ||||
| LUSC | -0.931 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser1154 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | -0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser1155 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.036 | ||||
| COAD | 1.036 | ||||
| HGSC | -0.195 | ||||
| ccRCC | |||||
| GBM | -0.85 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | 1.046 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser165 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.161 | ||||
| COAD | 0.425 | ||||
| HGSC | 0.852 | ||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | -1.438 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser225 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | 0.707 | ||||
| UCEC | |||||
| SRCIN1-Ser343 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.707 | ||||
| COAD | 0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser362 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.048 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 1.012 | ||||
| HNSC | |||||
| LUAD | -1.027 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | 0.89 | ||||
| UCEC | 0.173 | ||||
| SRCIN1-Ser366 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.707 | ||||
| SRCIN1-Ser39 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.776 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.352 | ||||
| HNSC | |||||
| LUAD | 1.128 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser434 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser436 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser439 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | -0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser45 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.927 | ||||
| COAD | 0.486 | ||||
| HGSC | -1.276 | ||||
| ccRCC | |||||
| GBM | 1.005 | ||||
| HNSC | 0.462 | ||||
| LUAD | -1.665 | ||||
| LUSC | 0.661 | ||||
| non_ccRCC | |||||
| PDAC | 0.452 | ||||
| UCEC | 0.802 | ||||
| SRCIN1-Ser473 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.707 | ||||
| HNSC | |||||
| LUAD | 0.707 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser474 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.707 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | 0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser493 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.14 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.413 | ||||
| HNSC | |||||
| LUAD | -0.727 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser513 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.137 | ||||
| COAD | 1.224 | ||||
| HGSC | |||||
| ccRCC | 0.137 | ||||
| GBM | -0.476 | ||||
| HNSC | |||||
| LUAD | -0.677 | ||||
| LUSC | |||||
| non_ccRCC | 1.774 | ||||
| PDAC | -0.464 | ||||
| UCEC | -0.38 | ||||
| SRCIN1-Ser517 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.727 | ||||
| COAD | 0.474 | ||||
| HGSC | 1.291 | ||||
| ccRCC | |||||
| GBM | -1.254 | ||||
| HNSC | |||||
| LUAD | -0.594 | ||||
| LUSC | 0.81 | ||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser522 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.712 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.628 | ||||
| HNSC | |||||
| LUAD | -1.705 | ||||
| LUSC | |||||
| non_ccRCC | 0.998 | ||||
| PDAC | 0.282 | ||||
| UCEC | 0.34 | ||||
| SRCIN1-Ser551 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.046 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | |||||
| HNSC | |||||
| LUAD | 0.1 | ||||
| LUSC | |||||
| non_ccRCC | 0.946 | ||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser64 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.634 | ||||
| HGSC | 0.429 | ||||
| ccRCC | -0.009 | ||||
| GBM | -0.64 | ||||
| HNSC | 0.405 | ||||
| LUAD | -1.91 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | 1.092 | ||||
| SRCIN1-Ser842 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.281 | ||||
| HGSC | |||||
| ccRCC | 0.124 | ||||
| GBM | -0.835 | ||||
| HNSC | 1.68 | ||||
| LUAD | -1.175 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | -0.075 | ||||
| SRCIN1-Ser844 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 1.148 | ||||
| COAD | 0.497 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -1.017 | ||||
| HNSC | |||||
| LUAD | -0.898 | ||||
| LUSC | -0.978 | ||||
| non_ccRCC | 1.535 | ||||
| PDAC | 0.204 | ||||
| UCEC | -0.491 | ||||
| SRCIN1-Ser866 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.035 | ||||
| COAD | 0.19 | ||||
| HGSC | 1.66 | ||||
| ccRCC | -0.319 | ||||
| GBM | -1.416 | ||||
| HNSC | 0.691 | ||||
| LUAD | -1.3 | ||||
| LUSC | 0.029 | ||||
| non_ccRCC | 1.198 | ||||
| PDAC | 0.588 | ||||
| UCEC | -0.286 | ||||
| SRCIN1-Ser875 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | 0.707 | ||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Ser907 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -0.758 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.671 | ||||
| HNSC | |||||
| LUAD | -0.745 | ||||
| LUSC | 0.917 | ||||
| non_ccRCC | |||||
| PDAC | 1.257 | ||||
| UCEC | |||||
| SRCIN1-Ser987 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | -1.878 | ||||
| COAD | 0.661 | ||||
| HGSC | 0.223 | ||||
| ccRCC | -0.252 | ||||
| GBM | -0.272 | ||||
| HNSC | 0.846 | ||||
| LUAD | -1.081 | ||||
| LUSC | -0.12 | ||||
| non_ccRCC | 1.966 | ||||
| PDAC | 0.154 | ||||
| UCEC | -0.249 | ||||
| SRCIN1-Thr52 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | |||||
| COAD | |||||
| HGSC | 0.707 | ||||
| ccRCC | |||||
| GBM | -0.707 | ||||
| HNSC | |||||
| LUAD | |||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | |||||
| UCEC | |||||
| SRCIN1-Thr596 | |||||
|---|---|---|---|---|---|
| Cancer | Intensity | ||||
| BRCA | 0.957 | ||||
| COAD | |||||
| HGSC | |||||
| ccRCC | |||||
| GBM | -0.614 | ||||
| HNSC | |||||
| LUAD | -1.079 | ||||
| LUSC | |||||
| non_ccRCC | |||||
| PDAC | 0.736 | ||||
| UCEC | |||||
| SRCIN1-Thr609 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.707 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | 0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
PTM-Disease Association:
source: PTMD| Residue | Position | State | Disease | Class | PMID |
|---|---|---|---|---|---|
| Y | 530 | D | Barrett's neoplasia | Phosphorylation | 14608530 |
| - | - | D | Clear cell renal cell carcinoma | Ubiquitination | 34936717 |
| - | - | D | Hepatocellular carcinoma | Ubiquitination | 31802035 |
| Y | 530 | D | Colorectal carcinoma | Phosphorylation | 17974954 |
| Y | 530 | D | Colon cancer/carcinoma | Phosphorylation | 23467908 |
| - | - | D | Cancer | Neddylation | 29899407 |
| Y | 527 | D | Hepatocellular carcinoma/hepatocarcinoma/hepatoma | Phosphorylation | 24296779 |
| Y | 419 | D | Oral squamous cell carcinoma | Phosphorylation | 23707351 |
| Y | 419 | D | Barrett's neoplasia | Phosphorylation | 14608530 |
| Y | 416 | D | Hepatocellular carcinoma/hepatocarcinoma/hepatoma | Phosphorylation | 24296779 |
| Y | 416 | D | Severe osteopetrosis | Phosphorylation | 23526378 |
| - | - | P | Breast cancer/tumor/carcinoma | Phosphorylation | 23353055 |
| Y | 416 | P | Hepatocellular carcinoma/hepatocarcinoma/hepatoma | Phosphorylation | 24296779 |
| Y | 527 | P | Hepatocellular carcinoma/hepatocarcinoma/hepatoma | Phosphorylation | 24296779 |
| - | - | P | Cervical squamous cell cancer | Phosphorylation | 23696930 |
| Y | 419 | P | Acute myeloid leukemia/acute myelogenous leukemia | Phosphorylation | 18056483 |
| Y | 419 | U | Triple-negative breast cancer | Phosphorylation | 26923594 |
| - | - | U | Non-small cell lung cancer | Phosphorylation | 37212571 |
| - | - | U | Breast cancer | Phosphorylation | 35896852 |
| T | 420 | U | Ovarian cancer | Phosphorylation | 32294438 |
| Y | 530 | U | Cancer | Phosphorylation | 37156751 |
| - | - | U | Cervical cancer/carcinoma | Phosphorylation | 24058594 |
| Y | 527 | U | Severe osteopetrosis | Phosphorylation | 23526378 |
| Y | 527 | U | Prostate cancer/carcinoma/adenocarcinoma | Phosphorylation | 23145001 |
| Y | 527 | U | Breast cancer/tumor/carcinoma | Phosphorylation | 21490376 |
| Y | 419 | U | Glioblastoma | Phosphorylation | 22323579 |
| Y | 419 | U | Gestational choriocarcinoma | Phosphorylation | 23671128 |
| Y | 418 | U | Breast cancer | Phosphorylation | 12753909 ; 12753909 |
| Y | 416 | U | Prostate cancer/carcinoma/adenocarcinoma | Phosphorylation | 23145001 |
| Y | 416 | U | Prostate cancer | Phosphorylation | 36084759 ; 17045208 ; 17045208 |
| Y | 416 | U | Ovarian cancer/carcinoma | Phosphorylation | 23277333 |
| Y | 416 | U | Hepatocellular carcinoma/hepatocarcinoma/hepatoma | Phosphorylation | 23524339 |
| Y | 416 | U | Non-small cell lung cancer | Phosphorylation | 35131384 |
| Y | 418 | U | Clear cell renal cell carcinoma | Phosphorylation | 35257717 |
| Y | 215 | U | Breast cancer | Phosphorylation | 12753909 ; 12753909 |
| Y | 419 | U | Triple-negative breast cancer | Phosphorylation | 26923594 |
| Y | 419 | U | Prostate cancer/carcinoma/adenocarcinoma | Phosphorylation | 17045208 |
| Y | 419 | U | Ovarian cancer | Phosphorylation | 32294438 |
| Y | 419 | U | Glioma/adult gliomas | Phosphorylation | 24358106 |
| Y | 419 | U | Colon cancer/carcinoma | Phosphorylation | 17148760 |
| Y | 419 | U | Breast cancer/tumor/carcinoma | Phosphorylation | 24358106 ; 26923594 ; 21490376 ; 17967179 |
| Y | 419 | U | Breast cancer | Phosphorylation | 17967179 |
State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
