| Id: | acc3315 |
| Group: | 2sens |
| Protein: | Akt |
| Gene Symbol: | MET |
| Protein Id: | Q9H8T0 |
| Protein Name: | AKTIP_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser473 |
| Site Sequence: | ------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------------ |
| Disease Category: | Cardiovascular and circulatory system diseases |
| Disease: | Atherosclerosis? |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | des-fluoro-anacetrapib? |
| Drug Info: | Des-fluoro-anacetrapib is a drug. It may have specific pharmacological effects and is used in relevant medical research or treatments. |
| Effect: | modulate |
| Effect Info: | "Increasing HDL levels through inhibiting cholesterol ester transfer protein can reduce intimal thickening and regenerate functional endothelium in the damaged aortas of New Zealand white rabbits in a scavenger receptor B1-dependent and phosphatidylinositol-4,5-bisphosphate 3-kinase/Akt-dependent manner. " |
| Note: | ID not sure |
| Score: | 4.0 |
| Pubmed(PMID): | 25633313 |
| Sentence Index: | 25633313_2-3 |
| Sentence: | "This study asks if increasing HDL levels by inhibiting cholesteryl ester transfer protein activity with the anacetrapib analog, des-fluoro-anacetrapib, enhances endothelial repair and improves endothelial function in New Zealand White rabbits with balloon injury of the abdominal aorta. APPROACH AND RESULTS: New Zealand White rabbits received chow or chow supplemented with 0.07% or 0.14% (wt/wt) des-fluoro-anacetrapib for 8 weeks." |
Sequence & Structure:
MNPFWSMSTSSVRKRSEGEEKTLTGDVKTSPPRTAPKKQLPSIPKNALPITKPTSPAPAAQSTNGTHASYGPFYLEYSLLAEFTLVVKQKLPGVYVQPSYRSALMWFGVIFIRHGLYQDGVFKFTVYIPDNYPDGDCPRLVFDIPVFHPLVDPTSGELDVKRAFAKWRRNHNHIWQVLMYARRVFYKIDTASPLNPEAAVLYEKDIQLFKSKVVDSVKVCTARLFDQPKIEDPYAISFSPWNPSVHDEAREKMLTQKKPEEQHNKSVHVAGLSWVKPGSVQPFSKEEKTVAT
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
