Id: acc3325
Group: 2sens
Protein: p21
Gene Symbol: CDKN1A
Protein Id: P38936
Protein Name: CDN1A_HUMAN
PTM: methylation
Site: Arg156
Site Sequence: MTDFYHSKRRLIFSKRKP---
Disease Category: Cancer
Disease: Colorectal Cancer
Disease Subtype:
Disease Cellline: HCT116
Disease Info:
Drug: doxorubicin
Drug Info: Doxorubicin is an anthracycline antibiotic used in cancer chemotherapy to treat a wide range of cancers.
Effect: inhibit
Effect Info: "PRMT6 methylates p21 at arginine 156 and promotes phosphorylation of p21 at threonine 145, leading to cell drug resistance."
Note:
Score: 5.0
Pubmed(PMID): 26436589
Sentence Index:
Sentence:

Sequence & Structure:

MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
- - A Pancreatic cancer/carcinoma/adenocarcinoma Acetylation 24301926
- - U Medulloblastoma Neddylation 29984917
T 145 U Prostate cancer Phosphorylation 34069970
- - U Breast cancer/tumor/carcinoma Ubiquitination 24027428

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: