Id: acc3327
Group: 2sens
Protein: p21
Gene Symbol: CDKN1A
Protein Id: P38936
Protein Name: CDN1A_HUMAN
PTM: phosphorylation
Site: Thr145
Site Sequence: DSQGRKRRQTSMTDFYHSKRR
Disease Category: Cancer
Disease: Colorectal Cancer
Disease Subtype:
Disease Cellline: HCT116
Disease Info:
Drug: doxorubicin
Drug Info: Doxorubicin is an anthracycline antibiotic used in cancer chemotherapy to treat a wide range of cancers.
Effect: inhibit
Effect Info: "PRMT6 methylates p21 at arginine 156 and promotes phosphorylation of p21 at threonine 145, leading to cell drug resistance."
Note:
Score: 5.0
Pubmed(PMID): 26436589
Sentence Index:
Sentence:

Sequence & Structure:

MSEPAGDVRQNPCGSKACRRLFGPVDSEQLSRDCDALMAGCIQEARERWNFDFVTETPLEGDFAWERVRGLGLPKLYLPTGPRRGRDELGGGRRPGTSPALLQGTAEEDHVDLSLSCTLVPRSGEQAEGSPGGPGDSQGRKRRQTSMTDFYHSKRRLIFSKRKP

Select PDB:

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets
Small molecule
Antibody
PROTAC
Other modalities
Approved Drug
Advanced Clinical
Phase 1 Clinical
Structure with Ligand
High-Quality Ligand
High-Quality Pocket
Med-Quality Pocket
Druggable Family
Approved Drug
Advanced Clinical
Phase 1 Clinical
UniProt loc high conf
GO CC high conf
UniProt loc med conf
UniProt SigP or TMHMM
GO CC med conf
Human Protein Atlas loc
Approved Drug
Advanced Clinical
Phase 1 Clinical
Literature
UniProt Ubiquitination
Database Ubiquitination
Half-life Data
Small Molecule Binder
Approved Drug
Advanced Clinical
Phase 1 Clinical

PTM Intensity:

source: CPTAC
CDKN1A-Ser130
Cancer Intensity
BRCA -1.129
COAD
HGSC
ccRCC 0.266
GBM 1.728
HNSC -0.567
LUAD -0.85
LUSC -0.21
non_ccRCC
PDAC
UCEC 0.763

PTM-Disease Association:

source: PTMD
Residue Position State Disease Class PMID
T 145 U Prostate cancer Phosphorylation 34069970

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links: