| Id: | acc3334 |
| Group: | 2sens |
| Protein: | GluA1 |
| Gene Symbol: | Gria1 |
| Protein Id: | P23818 |
| Protein Name: | GRIA1_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser845 |
| Site Sequence: | SKRMKGFCLIPQQSINEAIRT |
| Disease Category: | Pain syndromes |
| Disease: | Pain |
| Disease Subtype: | pain behaviors |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | IEM1460 |
| Drug Info: | "IEM1460 is a drug, and its specific properties and functions need further context for detailed description. " |
| Effect: | modulate |
| Effect Info: | "Microinjection of the AMPA receptor inhibitor IEM1460 into the ACC can effectively inhibit visceral pain and spontaneous pain behaviors. Meanwhile, an increase in the phosphorylation level of the AMPA receptor subunit GluA1 at the Ser845 site was observed, suggesting that this phosphorylation modification may promote the membrane trafficking of AMPA receptors, thereby affecting the transmission of pain signals." |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 26585043 |
| Sentence Index: | 26585043_8-9 |
| Sentence: | "Microinjection of AMPA receptor inhibitor IEM1460 into the ACC inhibited visceral and spontaneous pain behaviors. Furthermore, we found that the phosphorylation of GluA1 at the Ser845 site was increased, suggesting that GluA1 phosphorylation may contribute to AMPA receptor trafficking." |
Sequence & Structure:
MPYIFAFFCTGFLGAVVGANFPNNIQIGGLFPNQQSQEHAAFRFALSQLTEPPKLLPQIDIVNISDSFEMTYRFCSQFSKGVYAIFGFYERRTVNMLTSFCGALHVCFITPSFPVDTSNQFVLQLRPELQEALISIIDHYKWQTFVYIYDADRGLSVLQRVLDTAAEKNWQVTAVNILTTTEEGYRMLFQDLEKKKERLVVVDCESERLNAILGQIVKLEKNGIGYHYILANLGFMDIDLNKFKESGANVTGFQLVNYTDTIPARIMQQWRTSDARDHTRVDWKRPKYTSALTYDGVKVMAEAFQSLRRQRIDISRRGNAGDCLANPAVPWGQGIDIQRALQQVRFEGLTGNVQFNEKGRRTNYTLHVIEMKHDGIRKIGYWNEDDKFVPAATDAQAGGDNSSVQNRTYIVTTILEDPYVMLKKNANQFEGNDRYEGYCVELAAEIAKHVGYSYRLEIVSDGKYGARDPDTKAWNGMVGELVYGRADVAVAPLTITLVREEVIDFSKPFMSLGISIMIKKPQKSKPGVFSFLDPLAYEIWMCIVFAYIGVSVVLFLVSRFSPYEWHSEEFEEGRDQTTSDQSNEFGIFNSLWFSLGAFMQQGCDISPRSLSGRIVGGVWWFFTLIIISSYTANLAAFLTVERMVSPIESAEDLAKQTEIAYGTLEAGSTKEFFRRSKIAVFEKMWTYMKSAEPSVFVRTTEEGMIRVRKSKGKYAYLLESTMNEYIEQRKPCDTMKVGGNLDSKGYGIATPKGSALRGPVNLAVLKLSEQGVLDKLKSKWWYDKGECGSKDSGSKDKTSALSLSNVAGVFYILIGGLGLAMLVALIEFCYKSRSESKRMKGFCLIPQQSINEAIRTSTLPRNSGAGASGGSGSGENGRVVSQDFPKSMQSIPCMSHSSGMPLGATGL
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
