| Id: | acc3335 |
| Group: | 2sens |
| Protein: | A20 |
| Gene Symbol: | Tnfaip3 |
| Protein Id: | Q60769 |
| Protein Name: | TNAP3_MOUSE |
| PTM: | phosphorylation |
| Site: | Ser381 |
| Site Sequence: | PLEPSTPQLSLMDIKCETPNC |
| Disease Category: | Immune system diseases |
| Disease: | Inflammatory |
| Disease Subtype: | |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | TNF |
| Drug Info: | "TNF is a type of tumor necrosis factor, which can regulate immune responses and cell functions." |
| Effect: | modulate |
| Effect Info: | Phosphorylation of A20 promotes the hydrolysis of K63-linked polyubiquitin chains by its OTU domain and enhances substrate ubiquitination mediated by the ZnF4 domain. This phosphorylation process enhances the inhibitory effect of A20 on the TNF-induced inflammatory signaling pathway. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 26649818 |
| Sentence Index: | 26649818_3-4 |
| Sentence: | Here we utilize genetically engineered mice bearing mutations in the A20 ovarian tumour (OTU)-type deubiquitinase domain or in the zinc finger-4 (ZnF4) ubiquitin-binding motif to investigate these discrepancies. We find that phosphorylation of A20 promotes cleavage of Lys63-linked polyubiquitin chains by the OTU domain and enhances ZnF4-mediated substrate ubiquitination. |
Sequence & Structure:
MAEQLLPQALYLSNMRKAVKIRERTPEDIFKPTNGIIYHFKTMHRYTLEMFRTCQFCPQFREIIHKALIDRSVQASLESQKKLNWCREVRKLVALKTNGDGNCLMHAACQYMWGVQDTDLVLRKALCSTLKETDTRNFKFRWQLESLKSQEFVETGLCYDTRNWNDEWDNLVKMASADTPAARSGLQYNSLEEIHIFVLSNILRRPIIVISDKMLRSLESGSNFAPLKVGGIYLPLHWPAQECYRYPIVLGYDSQHFVPLVTLKDSGPELRAVPLVNRDRGRFEDLKVHFLTDPENEMKEKLLKEYLIVMEIPVQGWDHGTTHLINAAKLDEANLPKEINLVDDYFELVQHEYKKWQENSDQARRAAHAQNPLEPSTPQLSLMDIKCETPNCPFFMSVNTQPLCHECSERRQKNQSKLPKLNSKLGPEGLPGVGLGSSNWSPEETAGGPHSAPPTAPSLFLFSETTAMKCRSPGCPFTLNVQHNGFCERCHARQINASHTADPGKCQACLQDVTRTFNGICSTCFKRTTAEPSSSLTSSIPASCHQRSKSDPSQLIQSLTPHSCHRTGNVSPSGCLSQAARTPGDRAGTSKCRKAGCMYFGTPENKGFCTLCFIEYRENKQSVTASEKAGSPAPRFQNNVPCLGRECGTLGSTMFEGYCQKCFIEAQNQRFHEARRTEEQLRSSQHRDMPRTTQVASRLKCARASCKNILACRSEELCMECQHLSQRVGSVAHRGEPTPEEPPKQRCRAPACDHFGNAKCNGYCNECYQFKQMYG
Select PDB:
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
