| Id: | acc3340 |
| Group: | 2sens |
| Protein: | DARPP-32 |
| Gene Symbol: | Ppp1r1b |
| Protein Id: | Q6J4I0 |
| Protein Name: | PPR1B_RAT |
| PTM: | phosphorylation |
| Site: | Thr34 |
| Site Sequence: | VEMIRRRRPTPALLFRVSEHS |
| Disease Category: | Nervous system diseases |
| Disease: | Parkinson's Disease |
| Disease Subtype: | dyskinesia |
| Disease Cellline: | |
| Disease Info: | |
| Drug: | levodopa |
| Drug Info: | Levodopa is a medication commonly used in the treatment of Parkinson's disease. It helps to increase dopamine levels in the brain. |
| Effect: | modulate |
| Effect Info: | Tat-D1-t2 reduces levodopa-induced DARPP-32 Thr34 phosphorylation and alleviates dyskinesia. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 26893543 |
| Sentence Index: | 26893543_4-5 |
| Sentence: | "In this study, we demonstrated in 6-hydroxydopamine (6-OHDA)-lesioned PD rat model that intrastriatal injection of Tat-D1-t2 alleviated dyskinetic behaviors and downregulated the phosphorylation of DARPP-32 at Thr34 induced by levodopa. Moreover, we also showed intrastriatal administration of Tat-D1-t2 elicited alterations in membranous GluN1 and D1R expression." |
Sequence & Structure:
MDPKDRKKIQFSVPAPPSQLDPRQVEMIRRRRPTPALLFRVSEHSSPEEESSPHQRTSGEGHHPKSKRPNPCAYTPPSLKAVQRIAESHLQTISNLSENQASEEEDELGELRELGYPQEDDEEDEDEDEEEDEEEDSQAEVLKGSRGTAGQKLTSGQGLEGPWERPPPLDEPQRDGNSEDQGEGRATQSEPGEEPRHPTPPESGT
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo data.
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
