| Id: | acc3387 |
| Group: | 2sens |
| Protein: | hnRNPA1 |
| Gene Symbol: | HNRNPA1 |
| Protein Id: | P09651 |
| Protein Name: | ROA1_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser6 |
| Site Sequence: | ----MSKSESPKEPEQLRKLF |
| Disease Category: | Cancer |
| Disease: | Colorectal Cancer |
| Disease Subtype: | |
| Disease Cellline: | HCT116 |
| Disease Info: | |
| Drug: | S6K2 |
| Drug Info: | S6K2 is a drug that may play a role in certain biological processes and could be a target for specific medical treatments. |
| Effect: | modulate |
| Effect Info: | Phosphorylation of Ser6 in hnRNPA1 by S6K2 regulates glucose metabolism and cell growth in colorectal cancer. |
| Note: | Non-conventional drugs |
| Score: | 3.0 |
| Pubmed(PMID): | 29344170 |
| Sentence Index: | 29344170_7-8 |
| Sentence: | "In addition, chromatin immunoprecipitation assay indicated that S6K2 phosphorylation of Ser6 of hnRNPA1 facilitated hnRNPA1 binding to the splicing site of the PKM gene. As a result, cancer cells preferentially expressed the PKM2 isoform, instead of the PKM1 isoform." |
Sequence & Structure:
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTAC| HNRNPA1-Ser6 | |
|---|---|
| Cancer | Intensity |
| BRCA | -2.235 |
| COAD | -0.271 |
| HGSC | -0.25 |
| ccRCC | 0.236 |
| GBM | -0.565 |
| HNSC | 0.512 |
| LUAD | -0.268 |
| LUSC | 0.232 |
| non_ccRCC | 1.964 |
| PDAC | 0.471 |
| UCEC | 0.175 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
