| Id: | acc3388 |
| Group: | 2sens |
| Protein: | hnRNPA1 |
| Gene Symbol: | HNRNPA1 |
| Protein Id: | P09651 |
| Protein Name: | ROA1_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser6 |
| Site Sequence: | ----MSKSESPKEPEQLRKLF |
| Disease Category: | Cancer |
| Disease: | Colorectal Cancer |
| Disease Subtype: | |
| Disease Cellline: | HCT116 |
| Disease Info: | |
| Drug: | S6 kinase 2 (S6K2) |
| Drug Info: | "S6 kinase 2 (S6K2) is a member of the ribosomal S6 kinase family, which plays crucial roles in various cellular processes such as cell growth, proliferation, and survival." |
| Effect: | modulate |
| Effect Info: | S6K2 regulates glycolysis in CRC cells by phosphorylating the Ser6 residue of hnRNPA1. S6K2 promotes the proliferation of CRC cells by activating glycolysis. |
| Note: | |
| Score: | 4.0 |
| Pubmed(PMID): | 29344170 |
| Sentence Index: | 29344170_6-7 |
| Sentence: | "The results of the present study indicated that S6 kinase 2 (S6K2) promotes glycolysis and growth of CRC cells by regulating alternative splicing of the PKM gene. In addition, chromatin immunoprecipitation assay indicated that S6K2 phosphorylation of Ser6 of hnRNPA1 facilitated hnRNPA1 binding to the splicing site of the PKM gene." |
Sequence & Structure:
MSKSESPKEPEQLRKLFIGGLSFETTDESLRSHFEQWGTLTDCVVMRDPNTKRSRGFGFVTYATVEEVDAAMNARPHKVDGRVVEPKRAVSREDSQRPGAHLTVKKIFVGGIKEDTEEHHLRDYFEQYGKIEVIEIMTDRGSGKKRGFAFVTFDDHDSVDKIVIQKYHTVNGHNCEVRKALSKQEMASASSSQRGRSGSGNFGGGRGGGFGGNDNFGRGGNFSGRGGFGGSRGGGGYGGSGDGYNGFGNDGGYGGGGPGYSGGSRGYGSGGQGYGNQGSGYGGSGSYDSYNNGGGGGFGGGSGSNFGGGGSYNDFGNYNNQSSNFGPMKGGNFGGRSSGPYGGGGQYFAKPRNQGGYGGSSSSSSYGSGRRF
Select PDB:
No data.
Protein Tractability:
source: Open TargetsPTM Intensity:
source: CPTAC| HNRNPA1-Ser6 | |
|---|---|
| Cancer | Intensity |
| BRCA | -2.235 |
| COAD | -0.271 |
| HGSC | -0.25 |
| ccRCC | 0.236 |
| GBM | -0.565 |
| HNSC | 0.512 |
| LUAD | -0.268 |
| LUSC | 0.232 |
| non_ccRCC | 1.964 |
| PDAC | 0.471 |
| UCEC | 0.175 |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
