| Id: | acc3404 |
| Group: | 2sens |
| Protein: | calpastatin |
| Gene Symbol: | CAST |
| Protein Id: | P20810 |
| Protein Name: | ICAL_HUMAN |
| PTM: | phosphorylation |
| Site: | Ser633 |
| Site Sequence: | DNGQDKPVKPPTKKSEDSKKP |
| Disease Category: | Cancer |
| Disease: | Glioblastoma |
| Disease Subtype: | |
| Disease Cellline: | U87 |
| Disease Info: | |
| Drug: | radiation |
| Drug Info: | "Radiation is a physical agent used in medical treatment, often employed in radiotherapy to target and destroy cancer cells." |
| Effect: | inhibit |
| Effect Info: | "Phosphorylation at the S633 site promotes radioresistance by activating calpain, enhancing the survival ability and invasiveness of cancer cells." |
| Note: | Non-conventional drugs |
| Score: | 4.5 |
| Pubmed(PMID): | 29581866 |
| Sentence Index: | 29581866_8-9 |
| Sentence: | "We also showed that casein kinase 2, a pro-survival kinase overexpressed in many cancer types, phosphorylated calpastatin at Ser-633. Our results indicate that calpastatin phosphorylation promotes radiation resistance in GBM cells by increasing the activity of calpain proteases, which are known to promote survival and invasion in cancer." |
Sequence & Structure:
MNPTETKAIPVSQQMEGPHLPNKKKHKKQAVKTEPEKKSQSTKLSVVHEKKSQEGKPKEHTEPKSLPKQASDTGSNDAHNKKAVSRSAEQQPSEKSTEPKTKPQDMISAGGESVAGITAISGKPGDKKKEKKSLTPAVPVESKPDKPSGKSGMDAALDDLIDTLGGPEETEEENTTYTGPEVSDPMSSTYIEELGKREVTIPPKYRELLAKKEGITGPPADSSKPIGPDDAIDALSSDFTCGSPTAAGKKTEKEESTEVLKAQSAGTVRSAAPPQEKKRKVEKDTMSDQALEALSASLGTRQAEPELDLRSIKEVDEAKAKEEKLEKCGEDDETIPSEYRLKPATDKDGKPLLPEPEEKPKPRSESELIDELSEDFDRSECKEKPSKPTEKTEESKAAAPAPVSEAVCRTSMCSIQSAPPEPATLKGTVPDDAVEALADSLGKKEADPEDGKPVMDKVKEKAKEEDREKLGEKEETIPPDYRLEEVKDKDGKPLLPKESKEQLPPMSEDFLLDALSEDFSGPQNASSLKFEDAKLAAAISEVVSQTPASTTQAGAPPRDTSQSDKDLDDALDKLSDSLGQRQPDPDENKPMEDKVKEKAKAEHRDKLGERDDTIPPEYRHLLDDNGQDKPVKPPTKKSEDSKKPADDQDPIDALSGDLDSCPSTTETSQNTAKDKCKKAASSSKAPKNGGKAKDSAKTTEETSKPKDD
No data.
No data.
Protein Tractability:
source: Open TargetsNo data.
PTM Intensity:
source: CPTACNo intensity data of this site,
show all other sites!
| CAST-Ser106 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.855 |
| HGSC | 0.399 |
| ccRCC | -0.965 |
| GBM | |
| HNSC | |
| LUAD | 0.902 |
| LUSC | -0.651 |
| non_ccRCC | |
| PDAC | 1.647 |
| UCEC | -0.477 |
| CAST-Ser113 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | -0.928 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | -0.13 |
| UCEC | 1.059 |
| CAST-Ser128 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser129 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.317 |
| GBM | -0.979 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | 1.39 |
| PDAC | |
| UCEC | -0.094 |
| CAST-Ser132 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.402 |
| HGSC | 1.934 |
| ccRCC | |
| GBM | |
| HNSC | -0.29 |
| LUAD | -0.612 |
| LUSC | -1.027 |
| non_ccRCC | |
| PDAC | -0.305 |
| UCEC | 0.702 |
| CAST-Ser148 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.339 |
| HGSC | -2.214 |
| ccRCC | 0.442 |
| GBM | |
| HNSC | 0.783 |
| LUAD | 0.372 |
| LUSC | -0.036 |
| non_ccRCC | |
| PDAC | -0.546 |
| UCEC | 0.86 |
| CAST-Ser154 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.249 |
| HGSC | 1.683 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | -0.372 |
| non_ccRCC | |
| PDAC | -0.083 |
| UCEC | -0.979 |
| CAST-Ser170 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser175 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.707 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -0.707 |
| PDAC | |
| UCEC | |
| CAST-Ser182 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.707 |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser183 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.707 |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser189 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.54 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.786 |
| LUAD | -0.536 |
| LUSC | 0.17 |
| non_ccRCC | 1.291 |
| PDAC | -0.171 |
| UCEC | |
| CAST-Ser194 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.599 |
| COAD | 0.145 |
| HGSC | 1.723 |
| ccRCC | |
| GBM | |
| HNSC | -0.48 |
| LUAD | -0.09 |
| LUSC | 0.443 |
| non_ccRCC | |
| PDAC | -0.142 |
| UCEC | |
| CAST-Ser202 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.177 |
| LUAD | 0.035 |
| LUSC | 1.205 |
| non_ccRCC | -1.578 |
| PDAC | 0.162 |
| UCEC | |
| CAST-Ser210 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.707 |
| LUSC | -0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser216 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser233 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -0.707 |
| LUAD | 0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser241 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.499 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -0.442 |
| LUAD | -0.51 |
| LUSC | -0.546 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser243 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.259 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.496 |
| LUAD | -0.177 |
| LUSC | -0.779 |
| non_ccRCC | -1.451 |
| PDAC | 0.653 |
| UCEC | |
| CAST-Ser257 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.22 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.116 |
| LUAD | 0.427 |
| LUSC | -0.086 |
| non_ccRCC | -1.814 |
| PDAC | 0.137 |
| UCEC | |
| CAST-Ser278 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -1.081 |
| GBM | 0.892 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.189 |
| CAST-Ser279 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| CAST-Ser28 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.102 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -1.432 |
| PDAC | 0.832 |
| UCEC | 0.498 |
| CAST-Ser283 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.883 |
| GBM | |
| HNSC | -0.203 |
| LUAD | 1.086 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser284 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.695 |
| GBM | |
| HNSC | -0.451 |
| LUAD | 1.146 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser285 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.469 |
| GBM | 1.059 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -1.157 |
| PDAC | |
| UCEC | 0.567 |
| CAST-Ser297 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.687 |
| HGSC | |
| ccRCC | -1.754 |
| GBM | |
| HNSC | 0.554 |
| LUAD | 0.173 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.339 |
| CAST-Ser298 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.262 |
| HGSC | |
| ccRCC | -0.154 |
| GBM | 1.542 |
| HNSC | -0.159 |
| LUAD | 0.495 |
| LUSC | |
| non_ccRCC | -1.796 |
| PDAC | |
| UCEC | -0.188 |
| CAST-Ser30 | |
|---|---|
| Cancer | Intensity |
| BRCA | 2.191 |
| COAD | 0.034 |
| HGSC | 0.519 |
| ccRCC | -0.818 |
| GBM | |
| HNSC | 0.003 |
| LUAD | -0.599 |
| LUSC | -1.376 |
| non_ccRCC | |
| PDAC | -0.026 |
| UCEC | 0.072 |
| CAST-Ser304 | |
|---|---|
| Cancer | Intensity |
| BRCA | 2.244 |
| COAD | -0.375 |
| HGSC | 0.214 |
| ccRCC | -1.408 |
| GBM | |
| HNSC | 0.227 |
| LUAD | 0.194 |
| LUSC | 0.004 |
| non_ccRCC | |
| PDAC | -0.773 |
| UCEC | -0.329 |
| CAST-Ser310 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 1.166 |
| LUAD | -0.367 |
| LUSC | 0.97 |
| non_ccRCC | -0.895 |
| PDAC | -0.874 |
| UCEC | |
| CAST-Ser312 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.616 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.444 |
| LUAD | 0.395 |
| LUSC | 0.363 |
| non_ccRCC | -2.023 |
| PDAC | 0.206 |
| UCEC | |
| CAST-Ser313 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser317 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.243 |
| ccRCC | -0.873 |
| GBM | |
| HNSC | -0.259 |
| LUAD | -0.588 |
| LUSC | 2.133 |
| non_ccRCC | |
| PDAC | -0.293 |
| UCEC | -0.362 |
| CAST-Ser319 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.29 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.124 |
| LUAD | -0.044 |
| LUSC | 0.561 |
| non_ccRCC | -1.72 |
| PDAC | -0.212 |
| UCEC | |
| CAST-Ser32 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.422 |
| ccRCC | 0.569 |
| GBM | |
| HNSC | 1.027 |
| LUAD | 0.387 |
| LUSC | 0.316 |
| non_ccRCC | 0.207 |
| PDAC | -0.807 |
| UCEC | -2.121 |
| CAST-Ser325 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 1.57 |
| LUAD | -0.388 |
| LUSC | -0.607 |
| non_ccRCC | -0.939 |
| PDAC | 0.365 |
| UCEC | |
| CAST-Ser329 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| CAST-Ser337 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| CAST-Ser339 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.632 |
| GBM | 1.393 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -0.81 |
| PDAC | |
| UCEC | 0.049 |
| CAST-Ser34 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.905 |
| COAD | 0.865 |
| HGSC | -0.953 |
| ccRCC | 1.559 |
| GBM | |
| HNSC | -0.919 |
| LUAD | -0.389 |
| LUSC | -0.28 |
| non_ccRCC | 0.956 |
| PDAC | -0.331 |
| UCEC | -1.413 |
| CAST-Ser348 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.319 |
| GBM | |
| HNSC | 0.357 |
| LUAD | 0.789 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.466 |
| CAST-Ser353 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.133 |
| GBM | 1.15 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -1.264 |
| PDAC | |
| UCEC | 0.247 |
| CAST-Ser356 | |
|---|---|
| Cancer | Intensity |
| BRCA | 2.065 |
| COAD | |
| HGSC | -0.677 |
| ccRCC | -0.74 |
| GBM | |
| HNSC | 0.123 |
| LUAD | 0.055 |
| LUSC | 0.019 |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.844 |
| CAST-Ser358 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.682 |
| COAD | -0.128 |
| HGSC | -1.266 |
| ccRCC | -1.178 |
| GBM | |
| HNSC | 0.815 |
| LUAD | 0.049 |
| LUSC | -0.635 |
| non_ccRCC | |
| PDAC | 0.993 |
| UCEC | -0.333 |
| CAST-Ser36 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser367 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser372 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.347 |
| COAD | -0.006 |
| HGSC | 2.507 |
| ccRCC | -0.835 |
| GBM | |
| HNSC | -0.386 |
| LUAD | -0.179 |
| LUSC | -0.519 |
| non_ccRCC | |
| PDAC | -0.371 |
| UCEC | -0.557 |
| CAST-Ser381 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser386 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.308 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.522 |
| LUAD | 0.096 |
| LUSC | -0.568 |
| non_ccRCC | -1.618 |
| PDAC | 0.261 |
| UCEC | |
| CAST-Ser406 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.553 |
| GBM | 0.301 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | 0.631 |
| PDAC | |
| UCEC | -1.485 |
| CAST-Ser408 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.357 |
| GBM | 1.212 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -1.077 |
| PDAC | |
| UCEC | -0.492 |
| CAST-Ser415 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.081 |
| GBM | 0.541 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -1.369 |
| PDAC | |
| UCEC | 0.909 |
| CAST-Ser421 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.863 |
| GBM | 0.643 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -0.159 |
| PDAC | |
| UCEC | -1.348 |
| CAST-Ser425 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.051 |
| HGSC | -2.056 |
| ccRCC | 0.281 |
| GBM | |
| HNSC | 0.921 |
| LUAD | 0.478 |
| LUSC | 0.864 |
| non_ccRCC | |
| PDAC | 0.331 |
| UCEC | -0.871 |
| CAST-Ser427 | |
|---|---|
| Cancer | Intensity |
| BRCA | 0.696 |
| COAD | 0.573 |
| HGSC | -2.348 |
| ccRCC | -0.156 |
| GBM | |
| HNSC | 0.571 |
| LUAD | 0.536 |
| LUSC | 0.513 |
| non_ccRCC | |
| PDAC | 0.399 |
| UCEC | -0.784 |
| CAST-Ser434 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.222 |
| COAD | -0.222 |
| HGSC | -2.378 |
| ccRCC | -0.253 |
| GBM | |
| HNSC | 0.32 |
| LUAD | 0.19 |
| LUSC | 0.658 |
| non_ccRCC | |
| PDAC | 0.06 |
| UCEC | 0.403 |
| CAST-Ser436 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser440 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.036 |
| GBM | |
| HNSC | 0.616 |
| LUAD | 0.489 |
| LUSC | 0.859 |
| non_ccRCC | |
| PDAC | -0.094 |
| UCEC | -1.906 |
| CAST-Ser443 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser445 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.94 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 1.271 |
| LUSC | -0.638 |
| non_ccRCC | |
| PDAC | 0.306 |
| UCEC | |
| CAST-Ser46 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -0.038 |
| LUAD | -0.288 |
| LUSC | -0.536 |
| non_ccRCC | 1.707 |
| PDAC | -0.846 |
| UCEC | |
| CAST-Ser462 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -0.707 |
| LUAD | 0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser472 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.038 |
| HGSC | 0.942 |
| ccRCC | |
| GBM | |
| HNSC | -1.393 |
| LUAD | 0.414 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser473 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.647 |
| LUAD | 0.44 |
| LUSC | 0.384 |
| non_ccRCC | -1.774 |
| PDAC | 0.304 |
| UCEC | |
| CAST-Ser481 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser482 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.336 |
| GBM | 0.851 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -1.448 |
| PDAC | |
| UCEC | 0.261 |
| CAST-Ser501 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.698 |
| COAD | 0.357 |
| HGSC | 1.081 |
| ccRCC | -0.837 |
| GBM | |
| HNSC | 0.395 |
| LUAD | -0.312 |
| LUSC | -1.412 |
| non_ccRCC | |
| PDAC | -0.038 |
| UCEC | -0.933 |
| CAST-Ser51 | |
|---|---|
| Cancer | Intensity |
| BRCA | 1.144 |
| COAD | 1.15 |
| HGSC | -1.612 |
| ccRCC | 0.401 |
| GBM | -0.059 |
| HNSC | 0.203 |
| LUAD | 0.83 |
| LUSC | 0.528 |
| non_ccRCC | -0.483 |
| PDAC | -0.293 |
| UCEC | -1.809 |
| CAST-Ser510 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser52 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.23 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 1.307 |
| LUSC | -0.724 |
| non_ccRCC | 0.173 |
| PDAC | 0.474 |
| UCEC | |
| CAST-Ser520 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.832 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.456 |
| LUAD | 0.819 |
| LUSC | 0.784 |
| non_ccRCC | -0.366 |
| PDAC | 0.139 |
| UCEC | |
| CAST-Ser522 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.707 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | -0.707 |
| UCEC | |
| CAST-Ser54 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -1.071 |
| GBM | -0.982 |
| HNSC | |
| LUAD | 0.553 |
| LUSC | 1.229 |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.271 |
| CAST-Ser55 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.613 |
| HGSC | -1.204 |
| ccRCC | -0.15 |
| GBM | 0.654 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 1.313 |
| CAST-Ser560 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.751 |
| COAD | |
| HGSC | |
| ccRCC | -0.835 |
| GBM | |
| HNSC | |
| LUAD | 1.507 |
| LUSC | -0.443 |
| non_ccRCC | |
| PDAC | 0.521 |
| UCEC | |
| CAST-Ser568 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -1.025 |
| GBM | 1.374 |
| HNSC | |
| LUAD | -0.149 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.2 |
| CAST-Ser569 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.264 |
| GBM | 0.991 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -1.281 |
| PDAC | |
| UCEC | 0.554 |
| CAST-Ser57 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.432 |
| HGSC | -1.659 |
| ccRCC | -0.072 |
| GBM | |
| HNSC | 0.322 |
| LUAD | 0.976 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser577 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.364 |
| HGSC | |
| ccRCC | -1.2 |
| GBM | |
| HNSC | -0.316 |
| LUAD | 1.152 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser58 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.46 |
| HGSC | -1.742 |
| ccRCC | |
| GBM | 0.059 |
| HNSC | |
| LUAD | |
| LUSC | 0.647 |
| non_ccRCC | |
| PDAC | 0.576 |
| UCEC | |
| CAST-Ser587 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -1.4 |
| GBM | |
| HNSC | 0.101 |
| LUAD | 0.953 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.346 |
| CAST-Ser588 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -1.795 |
| GBM | |
| HNSC | 0.94 |
| LUAD | 0.567 |
| LUSC | 0.466 |
| non_ccRCC | |
| PDAC | 0.323 |
| UCEC | -0.501 |
| CAST-Ser600 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.707 |
| LUAD | |
| LUSC | -0.707 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser610 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser616 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| CAST-Ser617 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | 0.707 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -0.707 |
| PDAC | |
| UCEC | |
| CAST-Ser618 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| CAST-Ser619 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.764 |
| HGSC | -1.132 |
| ccRCC | |
| GBM | 0.368 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser622 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser624 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser632 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser636 | |
|---|---|
| Cancer | Intensity |
| BRCA | -2.04 |
| COAD | 0.128 |
| HGSC | 1.39 |
| ccRCC | 0.514 |
| GBM | |
| HNSC | 0.17 |
| LUAD | 0.521 |
| LUSC | 0.487 |
| non_ccRCC | |
| PDAC | -0.136 |
| UCEC | -1.033 |
| CAST-Ser638 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.789 |
| HGSC | -0.249 |
| ccRCC | -0.889 |
| GBM | |
| HNSC | 1.554 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | -0.164 |
| UCEC | -1.041 |
| CAST-Ser644 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser646 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Ser67 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.625 |
| HGSC | -1.494 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.453 |
| LUSC | |
| non_ccRCC | |
| PDAC | 0.417 |
| UCEC | |
| CAST-Ser696 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.707 |
| CAST-Ser716 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.835 |
| HGSC | |
| ccRCC | 0.852 |
| GBM | |
| HNSC | 0.207 |
| LUAD | |
| LUSC | -0.339 |
| non_ccRCC | |
| PDAC | |
| UCEC | -1.555 |
| CAST-Ser72 | |
|---|---|
| Cancer | Intensity |
| BRCA | -0.947 |
| COAD | -0.241 |
| HGSC | |
| ccRCC | 0.061 |
| GBM | |
| HNSC | -1.265 |
| LUAD | 0.189 |
| LUSC | 0.22 |
| non_ccRCC | 2.084 |
| PDAC | -0.101 |
| UCEC | |
| CAST-Ser82 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.707 |
| CAST-Ser92 | |
|---|---|
| Cancer | Intensity |
| BRCA | -1.315 |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.083 |
| LUAD | 0.57 |
| LUSC | 1.235 |
| non_ccRCC | -1.078 |
| PDAC | 0.505 |
| UCEC | |
| CAST-Thr134 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.381 |
| HGSC | 0.754 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | -1.134 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Thr156 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | -0.707 |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Thr186 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.707 |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Thr196 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.586 |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 1.069 |
| LUAD | -0.558 |
| LUSC | |
| non_ccRCC | |
| PDAC | -1.097 |
| UCEC | |
| CAST-Thr23 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | 0.707 |
| ccRCC | |
| GBM | |
| HNSC | -0.707 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Thr282 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -1.034 |
| GBM | 0.962 |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.072 |
| CAST-Thr301 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.13 |
| HGSC | -0.75 |
| ccRCC | -1.627 |
| GBM | |
| HNSC | 0.543 |
| LUAD | 0.737 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | 0.967 |
| CAST-Thr31 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.463 |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -1.148 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | 0.684 |
| UCEC | |
| CAST-Thr310 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.707 |
| HGSC | -0.707 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Thr32 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | -0.707 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Thr327 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | -0.707 |
| ccRCC | 0.707 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Thr346 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.707 |
| GBM | |
| HNSC | -0.707 |
| LUAD | |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Thr374 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | -0.229 |
| LUAD | 0.862 |
| LUSC | 0.685 |
| non_ccRCC | -1.317 |
| PDAC | |
| UCEC | |
| CAST-Thr470 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | 0.508 |
| GBM | |
| HNSC | |
| LUAD | |
| LUSC | |
| non_ccRCC | -1.152 |
| PDAC | |
| UCEC | 0.644 |
| CAST-Thr489 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | -0.897 |
| GBM | |
| HNSC | -0.46 |
| LUAD | 1.212 |
| LUSC | 0.94 |
| non_ccRCC | |
| PDAC | |
| UCEC | -0.795 |
| CAST-Thr69 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | 0.567 |
| HGSC | -1.155 |
| ccRCC | |
| GBM | |
| HNSC | |
| LUAD | 0.588 |
| LUSC | |
| non_ccRCC | |
| PDAC | |
| UCEC | |
| CAST-Thr94 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 1.121 |
| LUAD | -0.322 |
| LUSC | |
| non_ccRCC | |
| PDAC | -0.8 |
| UCEC | |
| CAST-Tyr164 | |
|---|---|
| Cancer | Intensity |
| BRCA | |
| COAD | |
| HGSC | |
| ccRCC | |
| GBM | |
| HNSC | 0.173 |
| LUAD | -1.075 |
| LUSC | 0.902 |
| non_ccRCC | |
| PDAC | |
| UCEC | |
PTM-Disease Association:
source: PTMDNo data.
PTM-Drug Perturbation Response:
source: DecryptMNo data.
Function score:
source: funscoRNo data.
