PMADS

Id:	acc3409
Group:	2sens
Protein:	Akt
Gene Symbol:	Akt1
Protein Id:	P31750
Protein Name:	AKT1_MOUSE
PTM:	phosphorylation
Site:	Ser473
Site Sequence:	ERRPHFPQFSYSASGTA----
Disease Category:	Immune system diseases
Disease:	Inflammation
Disease Subtype:
Disease Cellline:	RAW264.7
Disease Info:
Drug:	Solanine A
Drug Info:	Solanine A is a chemical compound. It may have certain biological activities and toxic properties.
Effect:	modulate
Effect Info:	"Solanine A exhibits potent anti - inflammatory activity in LPS/IFNγ - activated macrophages and inflammatory animal models by inhibiting the NF - κB, ERK1/2, Akt, and STAT1 signaling pathways."
Note:
Score:	4.0
Pubmed(PMID):	29890469
Sentence Index:	29890469_4-5
Sentence:	"The mRNA levels of inducible nitric oxide synthase (iNOS), cyclooxygenase-2 (COX2), tumor necrosis factor-alpha (TNF-alpha), interleukin-6 (IL-6), and -1beta (IL-1beta), as well as C-X-C motif chemokine ligand-9 (CXCL9), were significantly decreased by solanine A. Furthermore, solanine A also suppressed LPS/IFNgamma-induced protein expression of iNOS and COX2. Mechanistically, solanine A inhibited the nuclear translocation of nuclear factor-kappaB (NF-kappaB) through the prevention of NF-kappaB p65 and inhibitory kappaB-alpha (IkappaBalpha) phosphorylation and IkappaBalpha degradation, and it also suppressed activation of extracellular regulated protein kinases (ERK), signal transducers and activators of transcription-1 (STAT1) and serine/threonine protein kinase Akt in LPS/IFNgamma-stimulated RAW264.7 macrophages and agar-induced granuloma model in mice."

Sequence & Structure:

MNDVAIVKEGWLHKRGEYIKTWRPRYFLLKNDGTFIGYKERPQDVDQRESPLNNFSVAQCQLMKTERPRPNTFIIRCLQWTTVIERTFHVETPEEREEWATAIQTVADGLKRQEEETMDFRSGSPSDNSGAEEMEVSLAKPKHRVTMNEFEYLKLLGKGTFGKVILVKEKATGRYYAMKILKKEVIVAKDEVAHTLTENRVLQNSRHPFLTALKYSFQTHDRLCFVMEYANGGELFFHLSRERVFSEDRARFYGAEIVSALDYLHSEKNVVYRDLKLENLMLDKDGHIKITDFGLCKEGIKDGATMKTFCGTPEYLAPEVLEDNDYGRAVDWWGLGVVMYEMMCGRLPFYNQDHEKLFELILMEEIRFPRTLGPEAKSLLSGLLKKDPTQRLGGGSEDAKEIMQHRFFANIVWQDVYEKKLSPPFKPQVTSETDTRYFDEEFTAQMITITPPDQDDSMECVDSERRPHFPQFSYSASGTA

No data.

Known Drugs:

source: Multi-Sources

(see table)

No data.

Protein Tractability:

source: Open Targets

No data.

PTM Intensity:

source: CPTAC

No data.

PTM-Disease Association:

source: PTMD

Residue	Position	State	Disease	Class	PMID
S	473	D	Alzheimer's disease	Phosphorylation	35834993 ; 36843923
S	473	D	Colonic inflammation	Phosphorylation	36735734
S	473	D	Diabetes mellitus	Phosphorylation	17130464 ; 16777975 ; 15033922 ; 15033922 ; 16777975 ; 17130464 ; 35739993
S	473	D	Turner syndrome	Phosphorylation	33910978
S	473	U	Cardiomyopathy	Phosphorylation	35358489
S	473	U	Diabetes mellitus	Phosphorylation	35358489
S	473	U	Endometrial cancer/carcinoma	Phosphorylation	16585156
S	473	U	Melanoma	Phosphorylation	26565903
S	473	U	Non-small cell lung cancer	Phosphorylation	35961388
S	473	U	Hepatocellular carcinoma	Phosphorylation	33500384

State Note: Based on the distinct PTM states in diseases, PTMD classified all disease-associated PTMs into six classes, including whether the up-regulation (U) or down-regulation (D) of PTM levels, the absence (A) or presence (P) of PTMs, and the creation (C) or disruption (N) of PTM sites are associated with diseases.

PTM-Drug Perturbation Response:

source: DecryptM

No data.

Function score:

source: funscoR

No data.

Cross Links:

CTD
DMRdb